A5100600681- Sperm and Testicular Function
- Heat shock proteins research
- Reproductive Biology and Fertility
- Electrocatalysts for Energy Conversion
- Exercise and Physiological Responses
- Healthcare and Venom Research
- Medicinal Plant Pharmacodynamics Research
- Quantum Computing Algorithms and Architecture
- Polyomavirus and related diseases
- Sphingolipid Metabolism and Signaling
- Metal-Catalyzed Oxygenation Mechanisms
- Metastasis and carcinoma case studies
- Biological Stains and Phytochemicals
- Numerical Methods and Algorithms
- Toxin Mechanisms and Immunotoxins
- Parallel Computing and Optimization Techniques
- Cancer Mechanisms and Therapy
- Asthma and respiratory diseases
- Seaweed-derived Bioactive Compounds
- Phytochemical compounds biological activities
- Colorectal and Anal Carcinomas
- Plant Physiology and Cultivation Studies
- Food Allergy and Anaphylaxis Research
- Pharmacological Effects of Natural Compounds
- Urinary and Genital Oncology Studies
Sichuan University
2007-2024
State Key Laboratory of Biotherapy
2023-2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Huazhong University of Science and Technology
2014-2024
National Medical Products Administration
2023
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Bengbu Medical College
2023
China Pharmaceutical University
2023
This work demonstrates that non-redox metal ions as Lewis acids can sharply improve the oxygen transfer efficiency of a manganese(II) catalyst having non-heme ligand. In absence acid, oxidation complex will generate known di-μ-oxo-bridged dinuclear Mn2(III,IV) core which is very sluggish for olefin epoxidation. Adding causes dissociation core, leading to sharp improvement in its efficiency.
A fully developed, functional epididymis is important for male fertility. In particular, it apparent that without the most proximal region, initial segment (IS), infertility results. Therefore, to understand development and regulation of this crucial epididymal region. We have previously shown many functions IS are regulated by luminal fluid factors/lumicrine factors from testis. This study provides evidence lumicrine activated ERK pathway only in epithelial cells Postnatal Day (P) 14 P19...
The initial segment of the epididymis is vital for male fertility; therefore, it important to understand mechanisms that regulate this region. Deprival testicular luminal fluid factors/lumicrine factors from results in a wave apoptosis segment. In study, combination protein array and microarray analyses was used examine early changes downstream signal transduction pathways following loss lumicrine factors. We discovered cascade events leading protection eventual apoptosis: first 6 h after...
Several genes expressed in the initial segment of epididymis depend on factors from testis that reach via luminal system. These include gamma-glutamyl transpeptidase mRNA IV (Ggt_pr4), steroid 5 alpha reductase (Srd5a1), glutathione peroxidase (Gpx5), and cystatin-related epididymal spermatogenic (Cst8) genes. Promoter analyses indicated these contain several ETS DNA-binding sites. Members polyomavirus enhancer activator 3 (ETV4) family bind to sites promoter target regulate transcription....
Autotaxin (ATX) and lysophosphatidic acid (LPA) play an important role in pathogenesis of idiopathic pulmonary fibrosis (IPF). FTP-198 is oral, novel selective ATX inhibitor indicated for treating IPF. The study aimed to investigate the pharmacokinetics, pharmacodynamics, safety tolerability healthy subjects. A single-center, randomized, double-blind, placebo-controlled, single ascending-dose Phase I was performed. Pharmacokinetics, food effect on elimination, were evaluated. total 30...
Despite comprehensive systemic therapy, the treatment of patients with advanced colorectal cancer remains unsatisfactory. In specific case this study, subject was initially diagnosed liver metastasis from colon (microsatellite stable or proficient mismatch repair subtype), along incomplete intestinal obstruction and failure to respond chemotherapy. A clinical complete response achieved after five sessions transarterial chemoembolization combined hepatic arterial infusion chemotherapy,...
Background and objective: In addition to the standard antiepileptic drugs, traditional Chinese medicines (TCMs) are used for treatment of epilepsy in oriental countries. The interactions between drugs TCMs represent a potential problem clinical application. Because valproic acid (VPA), one most widely prescribed may be administered concomitantly with Paeoniae Radix (PR), famous TCMs, some epileptic patients, present study was conducted evaluate influences PR on pharmacokinetics VPA. Method:...
Tendinopathy is a disorder of musculoskeletal system that primarily affects athletes and the elderly. Current treatment options are generally comprised various exercise loading programs, therapeutic modalities, surgical interventions limited to pain management. This study understand role TRIM54 (tripartite motif containing 54) in tendonitis through vitro modeling with tendon-derived stem cells (TDSCs) vivo using rat tendon injury model. Initially, we observed overexpression TDSCs model...
Morbidity from allergic diseases is increasing. Basophils play a critical role in systemic anaphylaxis and chronic inflammation. The prenatal environment must be regarded as possible early risk factor for children. Our objective was to determine if basophils harvested neonates genetically predisposed atopic disease had different levels of CD63 expression IL-4 release properties response various stimuli (peptidoglycan, Dermatophagoides farinae, hyperosmotic mannitol). Blood samples were...
Bladder metastasis from lung cancer with epidermal growth factor receptor (EGFR) mutation is extremely rare. Here, we report a case of bladder adenocarcinoma EGFR mutation.A 53-year-old female patient was diagnosed advanced exon 19 deletion. Multiple nodules on the wall were found by regular examination pelvic cavity through computed tomography during targeted therapy. Further cystoscopy and histological biopsy tissues confirmed adenocarcinoma. In addition, genetic analysis revealed T790M...
Abstract Mitochondrial metabolism disorders play an important role in the occurrence and development of tumors, iron–sulfur protein is molecule for maintaining normal function mitochondria. However, relationship between expression, prognostic value, immune infiltration MMDS-related genes kidney renal clear cell carcinoma (KIRC) remains unclear. Based on online databases bioinformatics analysis was performed to evaluate expression differences, survival impacts, infiltration, significance...