A5049272364- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral-associated cancers and disorders
- Parathyroid Disorders and Treatments
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Alzheimer's disease research and treatments
- Medical Imaging and Pathology Studies
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Cardiomyopathy and Myosin Studies
- Vascular Tumors and Angiosarcomas
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Université Paris-Est Créteil
2021-2025
Assistance Publique – Hôpitaux de Paris
2017-2025
Hôpitaux Universitaires Henri-Mondor
2019-2025
Inserm
2019-2025
Institut Mondor de Recherche Biomédicale
2021-2025
Amyloidosis Foundation
2024
Centre Hospitalier Universitaire Henri-Mondor
2016-2022
Université Gustave Eiffel
2022
Hôpital Albert-Chenevier
2017-2022
Paris-Est Sup
2022
Significance Statement Targeting plasma cells to reduce the risk of antibody-mediated rejection and decreased allograft survival due anti-HLA donor-specific antibodies has not been explored in transplantation. After sensitizing eight rhesus macaques with two sequential mismatched skin allografts, authors desensitized four daratumumab (anti-CD38 mAb) plerixafor (anti-CXCR4) before transplant. Compared controls, daratumumab-treated animals had significantly reduced antibody levels prolonged...
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive most reported in Asia. We performed comprehensive clinical, pathological and genomic study of 71 European MEITL patients (36 males, 35 females, median age 67 years). The majority presented with gastrointestinal involvement had emergency surgery, 40% stage IV disease. tumors were morphologically classified into two groups: typical (58%) atypical (i.e., non-monomorphic or necrosis, angiotropism starry-sky...
There is no established standard treatment for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in patients who are not eligible to receive an intensive treatment. The combination of rituximab gemcitabine and oxaliplatin (R-GemOx) widely used this population but data scarce. We retrospectively collected the 196 with R/R DLBCL treated R-GemOx two French centers over a period 15 years. median age was 72 years (range, 24-89), 63% had international prognostic index 3 or higher 57%...
Lymphomas of T-follicular helper origin (T-follicular helper–cell lymphoma [TFHL]) are often accompanied by an expansion B-immunoblasts, occasionally with Hodgkin/Reed-Sternberg-like (HRS-like) cells, making the differential diagnosis classic Hodgkin (CHL) difficult. We compared morphologic, immunophenotypic, and molecular features 15 TFHL 12 CHL samples discussed 4 challenging cases uncertain diagnosis. Compared CHL, disclosed more frequent sparing subcortical sinuses, high-endothelium...
High-grade-B-cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements (double hit [HGBL-DH] or triple [HGBL-TH]), not otherwise specified (HGBL-NOS), are considered to be more aggressive diseases among large B-cell lymphomas (LBCL). CD19-targeting Chimeric Antigen Receptor (CAR) T-cells have changed the prognosis of chemoresistant LBCL. Clinical pathological data patients treated for relapsed/refractory LBCL HGBL in third line more, all characterized by FISH, were collected from...
This article reports a case of urogenital schistosomiasis mimicking IgG4-related disease (IgG4-RD) in 47-year-old immunocompromised man with HIV. Initially diagnosed IgG4-RD, further biopsies revealed schistosoma eggs. Elevated IgG4 levels indicated Th2 immune response, highlighting its complex role antischistosomal immunity and the need for careful differential diagnosis.
Cardiac amyloidosis (CA) has a poor prognosis which is aggravated by diagnostic delay. Amyloidosis extracardiac and cardiac events (AECE ACE) may help improve CA diagnosis typing. The aim of this study was to compare AECE ACE between different types assess their relationship with survival.This retrospective cohort conducted in France from June 2008 May 2019, at the Henry Mondor Hospital. This included 983 patients CA. Mean age inclusion 73.1 ± 11.4 years, 726 (75.1%) were male mean body mass...
ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22- R) or TP63 (TP63-R). Two studies reported 90% and 40% 5-year overall survival (OS) rates in 21 12 DUSP22-R/TP63- not rearranged (NR) patients, respectively, making the prognostic impact DUSP22-R unclear. Here, 104 newly diagnosed ALCL patients (including 37 from first-line clinical trials) LYSA TENOMIC database were analyzed by break-apart fluorescence situ hybridization assays...
Approximately 20%-50% of patients with large B-cell lymphoma (LBCL) experience poor outcomes. We aimed to evaluate the combined prognostic value circulating tumour DNA (ctDNA) and total metabolic volume (TMTV) in LBCL. This observational single-centre study included 112 newly diagnosed LBCL patients, receiving R-CHOP/R-CHOP-like chemotherapies. CtDNA load was calculated following next-generation sequencing cell-free (cfDNA) using a targeted 40-gene lymphopanel. TMTV measured fully automated...
Abstract Aims Predicting mortality in severe AL cardiac amyloidosis is challenging due to elevated biomarker levels and limited thresholds for stratifying damage. Methods results This prospective, observational, cohort study included de novo, confirmed patients at the Henri Mondor National Reference Centre. The goal was identify predictors of enhance prognostic stratification improve informed decision‐making regarding therapy. Over 12‐year period, among 233 included, 133 were NYHA III‐IV 179...
GATA2 mutations have been identified in various diseases, such as MonoMAC syndrome, Emberger familial myelodysplastic acute myeloid leukaemia and dendritic cell, monocyte, B‐cell natural killer‐cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections haematological disorders syndrome. Up to 70% patients with dermatological mainly genital or extragenital warts, panniculitis erythema nodosum lymphoedema. We report three presenting common...
Abstract Objective Angioimmunoblastic T‐cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require management unclear. Method from the multicentric database of Lymphoma Study Association presenting AIC during disease course were included matched to AITL without (1/5 ratio). Results At diagnosis, (n = 28) had more spleen bone marrow involvement (54% vs 19% 71% 34%, P < 0.001), Epstein‐Barr virus replication...
The three main cardiac amyloidosis (CA) types have different progression and prognosis. Little is known about the mode of death (MOD) which commonly attributed to cardiovascular causes in CA. Improving MOD's knowledge could allow adapt patient care.This retrospective study describes MOD that occurred during long-term follow-up CA patients light-chain (AL), transthyretin hereditary (ATTRv) or wild-type (ATTRwt).Patients referred cared for, at French referral centre for CA, Henri Mondor...
Primary effusion lymphoma (PEL) is associated with human herpesvirus 8 and frequently Epstein-Barr virus (EBV). We report here a single-center series of 19 immunodeficiency virus–associated PELs, including 14 EBV + 5 − PELs. The objectives were to describe the clinicopathologic features focus on programmed cell death protein 1 (PD-1)/programmed death-ligand (PD-L1) expression, search for genetic alterations by targeted deep sequencing analysis, compare between cases. All patients male,...
Cardiac amyloidosis (CA) is a set of amyloid diseases with usually predominant cardiac symptoms, including light-chain (AL), hereditary variant transthyretin (ATTRv), and wild-type (ATTRwt). CA are characterized by high heterogeneity in phenotypes leading to diagnosis delay worsened outcomes. The authors used clustering analysis identify typical clinical profiles large population patients suspected CA. Data were collected from the French Referral Center for Amyloidosis database (Hôpital...
Background Cardiac light chain amyloidosis (AL-CA) patients often die within three months of starting chemotherapy. Chemotherapy for non-immunoglobulin M gammopathy with AL-CA frequently includes bortezomib (Bor), cyclophosphamide (Cy), and dexamethasone (D). We previously reported that NT-ProBNP levels can double 24h administration, suggesting a deleterious impact on cardiac function. In this study, we evaluate the role in early cardiovascular mortality during treatment. Methods findings...