A5046139360- Acute Ischemic Stroke Management
- Multiple Sclerosis Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Alcoholism and Thiamine Deficiency
- Neurosurgical Procedures and Complications
- Neurological Complications and Syndromes
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Infectious Encephalopathies and Encephalitis
- Advanced Neuroimaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Vasculitis and related conditions
- Functional Brain Connectivity Studies
- Herpesvirus Infections and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Systemic Lupus Erythematosus Research
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular and Diving-Related Complications
Hôpital d'Instruction des Armées Sainte-Anne
2015-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Hôpitaux Universitaires de Strasbourg
2021
HIA du Val-de-Grâce à Paris
2017
Centre National de la Recherche Scientifique
2010-2016
Centre de Résonance Magnétique Biologique et Médicale
2010-2016
Aix-Marseille Université
2012-2016
Hôpital de Ville-Évrard
2014
Hôpital de la Timone
2009-2010
Hôtel-Dieu de Paris
1997
Objective: The present study aims to determine the clinical counterpart of brain resting-state networks reorganization recently evidenced in early multiple sclerosis. Methods: Thirteen patients with relapsing–remitting sclerosis and 14 matched healthy controls were included a resting state functional MRI performed at 3 T. Data analyzed using group spatial Independent Component Analysis concatenation approach (FSL 4.1.3) double regression analyses (SPM5) extract local global levels...
Objective To describe characteristics and outcomes of a multicenter cohort patients diagnosed as having primary angiitis the central nervous system (PACNS). Methods In 2010, we initiated study adults PACNS ≤15 years ago with followup >6 months (unless they died earlier biopsy‐proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators verified that appropriate investigations were done excluded possible alternative diagnoses. We analyzed patient demographics...
The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial.To characterize the relationships between changes and disability progression RRMS.Long-range connectivity, short-range density connections were assessed using graph theoretical analysis resting-state magnetic resonance imaging (fMRI) data acquired 38 RRMS patients (disease duration: 120 ± 32 months) 24 controls. All subjects explored at baseline all six...
Previous studies have demonstrated that cognitive impairment is already present in patients suffering from a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). However, little known about the course after occurrence CIS. In order to characterise early evolution impairment, authors assessed during 5-year follow-up period group 24 CIS with high risk developing MS. Longitudinal neuropsychological assessment was performed at two time points (baseline and year 5) controls...
A 60-year-old patient is presented who developed a stroke related to bilateral internal carotid artery dissection due elongated styloid processes and intense jerky head movements during unwonted shaking dance. The association between process cervicofacial pain well known as Eagle’s syndrome but its with exceptional. To our knowledge, this case the first observation of demonstrates that cervical CT angioscan very efficient non-invasive method diagnosing rare condition. A previously healthy...
The aim of the study was to assess prevalence, distribution and impact on disability grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome high risk developing sclerosis were included study. Forty-four healthy controls constituted normative population. An optimized statistical mapping analysis performed compare each subject's GM Magnetization Transfer Ratio (MTR) imaging maps those whole group controls. threshold significant MTR...
The impact of lesion location on cognitive functioning was assessed in a group 97 patients with clinically isolated syndrome. Using the Brief Repeatable Battery, we evidenced that 24% showed at least one abnormal test, 20% two and 15% three. Verbal learning performances were inversely associated presence lesions Broca's area, right frontal lobe splenium while spatial correlated to deep white matter. No associations between performance tasks exploring attention executive functions.
Background: Previous studies have demonstrated that intrathecal synthesis of IgM is observed in multiple sclerosis (MS) and correlates with a worse disease course. These results suggest participates the formation MS lesions. Objective: The aim present study was to assess potential association between level measured after clinically isolated syndrome (CIS) subsequent brain Methods: Fifty seven patients CIS high risk developing were enrolled longitudinal study. Examination cerebrospinal fluid...
In the last 6 months, 2 patients have been admitted to our stroke center for ischemic related internal carotid artery (ICA) dissection that occurred during intensive video sports game practice with Wii® gaming system, new generation of interactive wireless console. has widely distributed only since December 2006 and an increasing number associated-injury cases reported in literature June 2007 (severe osteoarticular injuries involving shoulder or knee hemothorax).1–4 These illustrate...
Breath-hold diving is a challenging activity that can lead to serious and dangerous complications, such as the "Taravana" syndrome. This syndrome characterized by onset of neurological symptoms after deep or repeated dives. The main clinical manifestations are cerebral, including stroke cognitive impairment. pathophysiology Taravana still widely debated, but most accepted theory it specific form decompression sickness. We have reviewed theories explaining and, through description...
<h3>Objective:</h3> To determine whether the ratio single chain (sc)/(sc + 2 [tc]) recombinant tissue plasminogen activator (rtPA) influences outcomes in patients with cerebral ischemia. <h3>Methods:</h3> We prospectively included consecutive treated IV rtPA for ischemia 13 stroke centers and determined sc/(sc tc) treatment administered to each patient. evaluated outcome modified Rankin Scale (mRS) at 3 months (prespecified analysis) occurrence of epileptic seizures (post hoc analysis)....
Foodborne botulism is rare in 21st century Western Europe. The purpose of this report to describe a collective case type A caused by ingestion artisanal-produced food (canned green beans and/or salted roast pork). Five the seven persons who shared meal presented signs severe intoxication leading fatal respiratory failure one 18-year-old girl. Three patients required mechanical ventilation for durations ranging from 37 78 days and developed infectious, psychiatric complications. In 4 out 5...
Background: The ability of conventional magnetic resonance imaging (MRI) to predict subsequent physical disability and cognitive deterioration after a clinically isolated syndrome (CIS) is weak. Objectives: We aimed investigate whether MRI changes over 1 year could 5 years later in CIS. performed analyses using global approach (T 2 lesion load, number T lesions), but also topographic approach. Methods: This study included 38 patients with At inclusion, 10 out fulfilled the 2010 revised...
Subacute sclerosing panencephalitis is an uncommon progressive neurological disorder caused by a persistent defective measles virus, typically affecting children. We describe case of fulminant subacute in 25-year-old male. Brain tissue biopsy showed histologic evidence encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic bodies, perivascular lymphoplasmacytic infiltration gliosis. Immunohistochemical studies were positive using anti-measles...