Jean-Philippe Cottier
A5103026504- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Radiation Dose and Imaging
- Intracranial Aneurysms: Treatment and Complications
- Ear and Head Tumors
- Facial Nerve Paralysis Treatment and Research
- Trigeminal Neuralgia and Treatments
- Advanced Neuroimaging Techniques and Applications
- Infectious Diseases and Tuberculosis
- S100 Proteins and Annexins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Image Segmentation Techniques
- Chemotherapy-related skin toxicity
- Radiomics and Machine Learning in Medical Imaging
- Ear Surgery and Otitis Media
- Meningioma and schwannoma management
Centre Hospitalier Universitaire de Tours
2015-2024
Université de Tours
2015-2023
Hôpital Bretonneau
2015-2022
Inserm
2015-2020
Imagerie et Cerveau
2020
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
<h3>BACKGROUND AND PURPOSE:</h3> The differential diagnosis of acute cervical pain includes nonvascular and vascular causes such as carotid dissection, occlusion, or vasculitis. However, some patients present with unclassified perivascular changes on imaging previously reported carotidynia. aim our study was to improve the description this yet clinico-radiologic entity. <h3>MATERIALS METHODS:</h3> From January 2009 through April 2016, 47 from 10 centers presenting neck tenderness at least 1...
Intravenous thrombolysis (IVT) with alteplase or tenecteplase before mechanical thrombectomy is the recommended treatment for large-vessel occlusion acute ischemic stroke. There are divergent data on whether these agents differ in terms of early recanalization (ER) rates thrombectomy, and little their potential differences stratified by ER predictors such as IVT to evaluation (IVT-to-ER
Background and Purpose— Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) still unclear; (2) may be harmful in unlikely recanalize; and, conversely, (3) transfer for MT unnecessary highly likely recanalize. Here, we determined predictors ER referred derive prediction scores trial design. Methods— Registries from 4 MT-capable...
Background and Purpose— In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site thrombus length, predictors post-IVT are poorly known. Better collaterals might also facilitate ER, for instance, by improving delivery thrombolytic agent both ends thrombus. this proof-of-concept study, we tested hypothesis that good independently predict before thrombectomy. Methods— Patients registries 6...
Background and Purpose- Whether bridging therapy, that is, intravenous thrombolysis [IVT] followed by mechanical thrombectomy, is beneficial as compared with IVT alone in minor stroke (National Institutes of Health Stroke Scale ≤5) large vessel occlusion unknown should be tested randomized trials. To help select the most appropriate candidates for such trials, we aimed to identify strong predictors lack post-IVT early recanalization (ER)-a surrogate marker poor outcome. Methods- From a...
Background: Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with large vessel occlusion unknown. Perfusion imaging may identify subsets of occlusion–related patients distinct response therapy. Methods: We conducted a multicenter international observational study consecutive IVT-treated (National Institutes Health Stroke Scale score ≤5) who had an anterior circulation and perfusion performed before IVT,...
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim our study was to report largest series MVNTs so far evaluate utility advanced multiparametric magnetic resonance (MR) techniques.This multicenter retrospective approved by institutional research ethics board. From July 2014 May 2019, two radiologists read in consensus MR examinations patients presenting an MVNT. They analyzed lesions' characteristics on...
Abstract A larger therapeutic window for stroke treatment requires a significant change in the organization of emergency services, avoiding increase number imaging exams and indirectly time to treatment. Objective: To highlight relation between faster clinical evaluation over-suspicion consequently excessive acquisition. identify predictors ischemic mimics (SM), aiming better patient selection comprehensive neuroimaging reperfusion therapies. Methods: Retrospective, cohort, observational,...
In large vessel occlusion (LVO) stroke, it is unclear whether severity of ischemia involved in early post-thrombolysis recanalization over and above thrombus site length. Here we assessed the relationships between perfusion parameters following intravenous thrombolysis administration LVO patients. From a multicenter registry, identified 218 thrombolysed patients referred for thrombectomy with both (i) pre-thrombolysis MRI, including diffusion-weighted imaging (DWI), T2*-imaging,...
Thrombus composition has the potential to affect acute ischemic stroke (AIS) treatment.To evaluate in an vitro test correlation of clot composition, especially erythrocytes (red blood cells (RBCs)), with variation signal intensity ratio (SIR) obtained MRI sequences used for AIS, and qualification susceptibility vessel sign effect using analogs.Nine ovine clots were fixed a gelatin-manganese solution studied by (T2GE, T2-weighted gradient echo; SWI, susceptibility-weighted imaging; FLAIR,...
Background: We recently reported a worrying 30% rate of early neurological deterioration (END) occurring within 24 hours following intravenous thrombolysis (IVT) in minor stroke with isolated internal carotid artery occlusion (ie, without additional intracranial occlusion), mainly due to artery-to-artery embolism. Here, we hypothesize that this setting IVT—as compared no-IVT—may foster END, particular by favoring embolism from thrombus fragmentation. Methods: From large multicenter...
<h3>BACKGROUND AND PURPOSE:</h3> Iodine contrast extravasation (ICE) is common in patients with acute ischemic stroke (AIS) after endovascular-thrombectomy (EVT). The aim of our study was to evaluate the incidence ICE assessed by dual-energy CT (DECT), its determinants, and associations clinical outcome. <h3>MATERIALS METHODS:</h3> We retrospectively examined imaging parameters factors from consecutive AIS treated EVT who had a DECT 24 hours thereafter, identified at single academic center....
<h3>BACKGROUND AND PURPOSE:</h3> FLAIR vascular hyperintensities are thought to represent leptomeningeal collaterals in acute ischemic stroke. However, whether all–FLAIR or hyperintensities–DWI mismatch, ie, beyond the DWI lesion, best reflects remains debated. We aimed compare value of mismatch versus for collateral assessment using PWI-derived flow maps as a reference. <h3>MATERIALS METHODS:</h3> retrospectively reviewed registries 6 large stroke centers and included all patients with...
Optimizing the care pathway of stroke is crucial for revascularization ischemic stroke.to identify factors associated with (1) a time interval over 4 h between symptom onset and cerebral imaging in suspected patients (2) absence stroke.Patients 18 years old admitted 22 emergency rooms or units one French region 1 March 2019 30 April were prospectively included by filling dedicated form.Factors previously mentioned outcome measures identified using logistic regression models.In total 991...
The pain management in oncologic patients requires a multidisciplinary approach. Considering bone metastases, multiple myeloma and lymphoma, percutaneous procedures like vertebroplasty can provide rapid relief. However, must be placed order to not delay systemic therapy or other modalities of treatment. In this article, we described our 15 years’ experience collaborating with team, reviewing literature special issues for spinal tumoral fractures.