A5083356029- Genetics and Physical Performance
- Trypanosoma species research and implications
- Pelvic floor disorders treatments
- Maternal and Perinatal Health Interventions
- Research on Leishmaniasis Studies
- Cervical Cancer and HPV Research
- Animal Behavior and Reproduction
- Pregnancy-related medical research
- Pharmacological Effects and Assays
- Meat and Animal Product Quality
- Sexual function and dysfunction studies
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Migraine and Headache Studies
- Maternal and fetal healthcare
- Lexicography and Language Studies
- Animal Behavior and Welfare Studies
- Pregnancy and preeclampsia studies
- Parasites and Host Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Children's Physical and Motor Development
- Linguistics and Discourse Analysis
- Neurobiology and Insect Physiology Research
- Pelvic and Acetabular Injuries
- Regulation of Appetite and Obesity
University of California, Davis
2021-2024
Université de Sherbrooke
2007-2024
St Mary's Hospital
2010-2024
McGill University
2010-2023
Jewish General Hospital
2022
Institute Cancer De La Loire Lucien Neuwirth
2021
Centre Hospitalier Universitaire de Rennes
2018-2021
Université de Lorraine
2021
University of Wisconsin–Madison
2001-2020
Agence Régionale de Santé Ile-de-France
2019
The hippocampus is important for the acquisition of new memories. It also one few regions in adult mammalian brain that can generate nerve cells. authors tested hypothesis voluntary exercise increases neurogenesis and enhances spatial learning mice selectively bred high levels wheel running (S mice). Female S outbred control (C) were housed with without wheels 40 days. 5-Bromodeoxyuridine was used to label dividing Morris water maze measure learning. C runners showed a strong positive...
The therapeutic mainstay against the protozoan parasite Leishmania is still based on antiquated pentavalent antimonials (Sb(V)), but resistance increasing in several parts of world. Resistance now partly understood laboratory isolates, our understanding field isolates lagging behind. We describe here a comparative analysis genetically related pair Sb(V)-sensitive and -resistant donovani strains isolated from kala-azar patients. resistant isolate exhibited cross-resistance to other unrelated...
Plasma levels of corticosterone (B) respond acutely to exercise in all mammals that have been studied, but the literature contains conflicting reports regarding how chronic activity alters this response. We measured acute and effects voluntary on B a novel animal model, mice selectively bred for high wheel running. Female were housed with or without wheels 8 wk beginning at 26 days age. Wheel-access selection had significantly higher night 8, day 15, 29, compared wheel-access controls....
ObjectivesThe resistance of clinical isolates Leishmania donovani to sodium antimony gluconate (SAG), the mainstay treatment in Indian visceral leishmaniasis, has become a critical issue India. The present work investigates mechanism SAG parasites isolated from patients who are unresponsive SAG.
Abstract To study the correlated evolution of locomotor behavior and exercise physiology, we conducted an artificial selection experiment. From outbred Hsd:ICR strain Mus domesticus, began eight separate lines, each consisting 10 breeding pairs. In four used within-family to increase voluntary wheel running. The remaining lines were random-bred (within lines) serve as controls. Various traits have been monitored test for responses. Here, report on organ masses, with emphasis triceps surae...
Abstract Objective: It remains uncertain whether leptin and adiponectin levels are correlated in maternal vs. fetal circulations. Little is known about affect insulin sensitivity during life. Design Methods: In a prospective singleton pregnancy cohort ( n = 248), we investigated concentrations (at 24‐28 32‐35 weeks of gestation) circulations, their associations with (glucose/insulin ratio, proinsulin level). Results: Comparing cord blood, were 50% lower, but more than doubled. Adjusting for...
Children conceived using Assisted Reproductive Technologies (ART) have a higher incidence of growth and birth defects, attributable in part to epigenetic perturbations. Both ART germline defects associated with parental infertility could interfere reprogramming events germ cells or early embryos. Mouse models indicate that the placenta is more susceptible induction abnormalities than embryo, thus placental methylome may provide sensitive indicator 'at risk' conceptuses. Our goal was use...
Perinatal route of transmission human papillomavirus (HPV) has been demonstrated in several small studies. We designed a large prospective cohort study (HERITAGE) to better understand perinatal HPV. The objective this article is present the design and preliminary data. In first phase study, we recruited 167 women Montreal, Canada, during trimester pregnancy. An additional 850 are currently being ongoing phase. Cervicovaginal samples were obtained from mothers tested for HPV DNA 36 mucosal...
How traits at multiple levels of biological organization evolve in a correlated fashion response to directional selection is poorly understood, but two popular models are the very general "behavior evolves first" (BEF) hypothesis and more specific "morphology-performance-behavior-fitness" (MPBF) paradigm. Both acknowledge that often acts relatively directly on behavior when evolves, other will as well most with some lag. However, this proposition exceedingly difficult test nature. Therefore,...
SUMMARY In nature, many animals use intermittent rather than continuous locomotion. laboratory studies, exercise regimens have been shown to increase endurance compared with exercise. We hypothesized that increased intermittency has evolved in lines of house mice (Mus domesticus) selectively bred for high voluntary wheel-running (wheel diameter 1.12 m) activity. After 23 generations, female from four replicate selection ran 2.7 times more revolutions per day individuals random-bred control...
The ATP-binding cassette (ABC) protein superfamily is one of the largest evolutionarily conserved families and found in all kingdoms life. recent completion Leishmania genome sequence allowed us to analyze classify its encoded ABC proteins. complete predicts a data set 42 open reading frames (ORFs) coding for proteins belonging superfamily, with representative members every major subfamily (from ABCA ABCH) commonly eukaryotes. Comparative analysis showed that same between infantum some...
It remains uncertain whether maternal IGF-I is associated with fetal growth. Little known about the role of IGF-II in growth and or implicated hypertrophy gestational diabetes.The objective study was to assess levels association diabetes. STUDY DESIGN, POPULATION, AND OUTCOMES: A singleton pregnancy cohort (n = 307). The primary outcome birth weight.Maternal plasma concentrations increased by an average 55.4% for 11.8% between 24-28 32-35 weeks gestation. but not level correlated weight...
OBJECTIVE Offspring of mothers with impaired glucose tolerance are far more likely to develop type 2 diabetes. We tested the hypothesis that maternal in pregnancy affects fetal insulin sensitivity or β-cell function. RESEARCH DESIGN AND METHODS In a prospective singleton cohort study, we analyzed glucose, insulin, and proinsulin concentrations blood at 50-g oral test (OGTT) 24–28 weeks gestation venous cord (n = 248). The glucose-to-insulin ratio concentration were used as indicators...
Background and Purpose— Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) still unclear; (2) may be harmful in unlikely recanalize; and, conversely, (3) transfer for MT unnecessary highly likely recanalize. Here, we determined predictors ER referred derive prediction scores trial design. Methods— Registries from 4 MT-capable...
The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health in children.Pregnant women their partners were recruited first trimester from nine sites Quebec followed along children through 2 years of age. Questionnaires administered post-delivery collect information on demographics, mental life style, medical history, psychosocial measures, diet, infant...