A5008012944- Cervical Cancer and HPV Research
- Genital Health and Disease
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Viral-associated cancers and disorders
- Gestational Diabetes Research and Management
- Blood transfusion and management
- Colorectal and Anal Carcinomas
- HIV/AIDS drug development and treatment
- Polyomavirus and related diseases
- Reproductive tract infections research
- Organ Transplantation Techniques and Outcomes
- Pregnancy and preeclampsia studies
- Liver Disease and Transplantation
- Urological Disorders and Treatments
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- HIV Research and Treatment
- Influenza Virus Research Studies
- Molecular Biology Techniques and Applications
- Blood donation and transfusion practices
- Heavy Metal Exposure and Toxicity
- Head and Neck Cancer Studies
Université de Montréal
2016-2025
Centre Hospitalier Universitaire Sainte-Justine
2015-2025
Canadian Apheresis Group
2023
Centre Hospitalier de l’Université de Montréal
2017-2020
Dalhousie University
2020
McGill University
2005-2015
General Department of Preventive Medicine
2012
College of Intensive Care Medicine
2012
Office of Infectious Diseases
2012
Institute of Social and Preventive Medicine
2012
Abstract Background: Besides an established role for certain human papillomavirus (HPV) genotypes in the etiology of cervical cancer, little is known about influence multiple-type HPV infections on lesion risk. We studied association between multiple types and lesions among 2,462 Brazilian women participating Ludwig-McGill study group investigation natural history HPVs neoplasia. Methods: Cervical specimens were typed by a PCR protocol. The cohort's repeated-measurement design permitted...
The intratypic variability of HPVs 16 and 18 has been extensively studied used as an important tool in epidemiological studies viral transmission, persistence progression to clinically relevant cervical lesions. Infections by non-European variants are associated with increased risk for the development high grade squamous intraepithelial lesions (HSIL). Our aim was correlate molecular both HPV types persistent infection lesion outcome a cohort study conducted Brazil. We characterized...
Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific among 2462 women enrolled Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4–6 months were tested by a polymerase chain reaction protocol. Actuarial techniques used to estimate HPV investigate influence age, number sexual partners, coinfection with multiple types....
Background. The current goal of antiretroviral therapy (ART) is to maintain a suppressed human immunodeficiency virus (HIV) viral load below limits assay detection. When loads remain in low-level viremia (LLV), especially between 50 and 200 copies/mL, the best management clinical consequences unknown. Our objective was study long-term impact persistent LLV on subsequent risk virologic failure cohort people living with HIV Montreal, Canada. Methods. We compared cumulative incidence (defined...
Human immunodeficiency virus (HIV)-seropositive men who have sex with (MSM) are at risk for anal intraepithelial neoplasia (AIN) and cancer. The goal of this study was to identify factors associated high-grade AIN (AIN-2,3) in HIV-positive MSM, including the receipt highly active antiretroviral therapy (HAART).A cohort involving 247 HIV-seropositive MSM receiving HAART or initiating followed up every 6 months 3 years human papillomavirus (HPV) testing high-resolution anoscopy predictors...
There is a paucity of data on whether or not women can be reinfected with human papillomavirus (HPV) types to which they were exposed earlier in life and the role natural immunity. The observation HPV infection at older ages may explained by reactivation latent new exposure from sexual activity. Our objective was analyze association between reinfection We analyzed 2,462 enrolled Ludwig-McGill cohort followed every 4 6 months for up 10 years. performed typing viral load measurements via PCR...
Objective: Use of preexposure prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence because decreased condom use among MSM. This study examines whether PrEP is associated with STIs in the 12 months following prescription relative to prior and if STI rates are higher users individuals receiving postexposure (PEP). Design: Retrospective cohort including more than follow-up before PEP from 2010 2015 at Clinique l'Actuel (Montréal, Canada). Methods:...
ABSTRACT Little is known on the dynamics of human papillomavirus (HPV) viral load during pregnancy and impact HPV vertical transmission. We described loads for several genotypes analyse its association with Data were analysed from HERITAGE study, a cohort pregnant women recruited between 2010 2016 in three centres Canada. Vaginal samples collected at first third trimesters pregnancy, placental birth, conjunctival, oral, pharyngeal, genital children birth 3 months tested DNA by Linear Array...
The authors estimated plausible ranges of the probability human papillomavirus (HPV) transmission per coital act among newly forming couples by using stochastic computer simulation. Comparative empirical data were obtained in 1996–2001 from a cohort study female university students Montreal, Canada. Female prevalence and frequency sexual intercourse condom use set equal to those cohort. Simulations included 240 combinations male prevalence, relative risk for protected versus unprotected sex,...
The optimal transfusion threshold after surgery in children is unknown. We analyzed the general subgroup of TRIPICU (Transfusion Requirements Pediatric Intensive Care Units) study to determine impact a restrictive versus liberal strategy on new or progressive multiple organ dysfunction syndrome (MODS).The study, prospective randomized controlled trial conducted 17 centers, enrolled total 648 critically ill with hemoglobin equal below 9.5 g/dL within 7 days pediatric intensive care unit...
Abstract Background Few studies have investigated delays in diagnosis and treatment among children adolescents with cancer, especially from the perspective of an entire country. Detailed understanding along continuum cancer patient care is important order to establish appropriate benchmarks for timely oncological care. Our objective was characterise different components delay 2,896 Canadian (aged 0–19 years) that were enrolled Treatment Outcome Surveillance component Childhood Cancer Control...
Background. Some studies have shown that tenofovir disoproxil fumarate (TDF), a drug widely used in highly active antiretroviral therapy, is associated with kidney dysfunction, but the magnitude of effect and its clinical impact still being debated. Our objective was to evaluate association between long-term TDF exposure dysfunction cohort 1043 human immunodeficiency virus–positive patients followed up for 10 years quantify loss estimated glomerular filtration rate (eGFR) exposed comparison...
Perinatal route of transmission human papillomavirus (HPV) has been demonstrated in several small studies. We designed a large prospective cohort study (HERITAGE) to better understand perinatal HPV. The objective this article is present the design and preliminary data. In first phase study, we recruited 167 women Montreal, Canada, during trimester pregnancy. An additional 850 are currently being ongoing phase. Cervicovaginal samples were obtained from mothers tested for HPV DNA 36 mucosal...
Toxic metals, such as lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg), may be associated with a higher risk of gestational hypertension preeclampsia, whereas manganese (Mn) is an essential metal that protective.
Active surveillance (AS) with deferred treatment is an established management option for patients prostate cancer and favorable clinical parameters. The impact of repeat biopsy after diagnosis was examined in a cohort men on AS.In all, 186 parameters or who refused were conservatively managed by AS. Of these, 92 had at least 1 diagnosis. Patients followed every 3 to 6 months prostate-specific antigen (PSA) physical examination offered rebiopsy annually if there any changes the PSA value....