A5083678235- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoplatforms for cancer theranostics
- Neurosurgical Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Photodynamic Therapy Research Studies
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Surgical Sutures and Adhesives
- Cervical and Thoracic Myelopathy
- Infectious Diseases and Tuberculosis
- Anatomy and Medical Technology
- Management of metastatic bone disease
- Wound Healing and Treatments
- MicroRNA in disease regulation
Paracelsus Medical University
2018-2025
Helsinki University Hospital
2019-2024
Christian Doppler Klinik
2017-2024
Institut des Sciences Cognitives Marc Jeannerod
2024
Neurological Surgery
2023
Unfallkrankenhaus Salzburg
2022-2023
Ludwig-Maximilians-Universität München
2012-2023
University of Helsinki
2019-2023
LMU Klinikum
2019-2021
MRC Prion Unit
2012
Oligodendroglial components (OC) and loss of heterozygosity on chromosomes 1p 19q (LOH 1p/19q) are associated with better outcome in patients glioma. We aimed to assess the fitness [(18)F]fluoroethyltyrosine positron-emission-tomography (FET-PET) for noninvasively identifying these important prognostic/predictive factors. One hundred forty-four MRI-suspected WHO grade II III glioma underwent FET-PET scans prior histological diagnosis. analyses included maximal tumoral uptake (SUV(max)/BG),...
Abstract Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at ~ 0.9% the adult population. Better holistic insights into glucocorticoid-induced changes crucial for effective as concurrent medication management adverse effects. The profiles 214 metabolites from plasma 20 male healthy volunteers were recorded prior to after ingestion a single dose 4 mg dexamethasone (+20 pantoprazole). Samples drawn three predefined time points per day:...
Interstitial photodynamic therapy (iPDT) using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) as a cytotoxic photosensitizer could be feasible treatment option for malignant gliomas. In monocentric cohort of consecutive patients treated between 2006 and 2018, risk profile analysis salvage iPDT local glioma recurrences associated outcome measures are presented here. It was considered indicated in with circumscribed biopsy-proven after standard therapy, if not deemed eligible...
Innovative, efficient treatments are desperately needed for people with glioblastoma (GBM).
A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk postoperative thromboembolic and hemorrhagic complications in CSDH with a history AF their association outcome. This posthoc analysis nationwide multicenter randomized controlled trial conducted during 2020-2022 included preoperative AF. incidence associations functional outcomes mortality. Of 589 patients, 128...
Abstract Assessment of the potential impact epilepsy as primary tumor manifestation on survival in elderly glioblastoma multiforme (GBM) patients. Two academic neurosurgical centers retrospectively analyzed all GBM patients aged 65 years and older with de-novo tumors, who underwent surgery between 2006 2021. Epidemiological, histopathological, imaging data were obtained from patients’ electronic charts, screened for presence preoperatively during follow-up. Patient status was assessed by...
Abstract BACKGROUND: Detailed data on long-term functional outcome of patients with World Federation Neurosurgical Societies (WFNS) grades IV and V aneurysmal subarachnoid hemorrhages (aSAH) are still scarce. OBJECTIVE: Assessment WFNS aSAH patients. METHODS: Functional quality life were assessed by the modified Rankin scale (mRS) 36-item short-form health survey in consecutively treated between 2005 2010. Scores from compared to a healthy German population. Prognostic factors analyzed uni-...
Treatment of middle cerebral artery (MCA) aneurysms has been historically considered as the almost exclusive domain microsurgical clipping. This retrospective single-center study assesses whether clipping or endovascular treatment (i.e. coiling and/or stenting) for MCA yielded better occlusion rates and clinical outcome.We identified patients with a minimum follow-up 12 months who had undergone aneurysm repair either by between 2005 2015. Aneurysm were assessed Raymond-Roy Occlusion...
Gliomas are the most common intrinsic brain tumors in adults, and accordance with their clinical behavior patients' outcome, they graded by World Health Organization (WHO) classification of tumors. One very interesting candidate for targeted tumor therapy may be epidermal growth factor receptor (EGFR) amplification. Here, we performed an integrated comparative analysis EGFR amplification 34 glioma samples using standard fluorescence situ hybridization (FISH) Illumina EPIC Infinium...
Manual moulding of cranioplasty implants after craniectomy is feasible, but does not always yield satisfying cosmetic results. In contrast, 3D printing can provide precise templates for intraoperative polymethylmethacrylate (PMMA) in cranioplasty. Here, we present a novel and easily implementable workflow to produce patient-specific, sterilisable PMMA implant cranioplastic neurosurgery.3D printable patients with large skull defects before were designed virtually from cranial CT scans. Both -...
Abstract Purpose We present results of a retrospective population-based investigation patterns care and outcome glioblastoma patients in Austria. Patients methods In this nation-wide cooperative project, all Austrian newly diagnosed between 2014 2018 registered the ABTR-SANOnet database were included. Histological typing used criteria WHO classification CNS tumors, 4th edition 2016. Patterns assessed, followed until end 2019. Results 1,420 adult cases identified. 813 (57.3%) male 607 (42.7%)...
// Andreas Mock 1 , Rolf Warta Christoph Geisenberger Ralf Bischoff 2,3 Alexander Schulte 4 Katrin Lamszus Volker Stadler 2 Thomas Felgenhauer Christian Schichor 5 Schwartz Jakob Matschke 6 Christine Jungk Rezvan Ahmadi Felix Sahm 7,8 David Capper Rainer Glass Jörg-Christian Tonn Manfred Westphal von Deimling Unterberg Justo Lorenzo Bermejo 9,10 and Christel Herold-Mende Department of Neurosurgery, Experimental University Heidelberg, Germany PEPperPRINT GmbH, 3 Division Functional Genome...
Abstract Purpose Gliomas are the most frequent primary brain tumors of adults. Despite intensive research, there still no targeted therapies available. Here, we performed an integrated analysis glioma and programmed cell death ligand 1 (PD-L1) in 90 samples including 58 32 control tissues. Methods To identify PD-L1 expression glioma, immunohistochemical tumor proportion score (TPS) using clinically valid 22C3 antibody on controls WHO grade I–IV gliomas. Results We found that is highly...
Surgical resection of intracranial meningiomas in patients that are 80 years old and older, i.e. very patients, is increasingly considered. Meningiomas with a largest diameter at least 5 cm-'giant meningiomas'-form distinct entity, their surgical considered more difficult prone to complications. Here, we evaluated functional outcome, morbidity mortality, the prognostic value tumor size who underwent giant supratentorial meningiomas.We retrospectively reviewed clinical radiological data,...
To assess the impact of individual surgeon experience on overall survival (OS), extent resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.GBM aged ≥ 65 years who underwent tumor at two academic centers were analyzed. The each neurosurgeon was quantified three ways: (1) total number previously glioma surgeries (lifetime experience); (2) previous five (medium-term experience) (3) last (short-term...
BACKGROUND AND OBJECTIVES: Demographic changes will lead to an increase in old patients, a population with significant risk of postoperative morbidity and mortality, requiring neurosurgery for meningiomas. This multicenter study aims report neurofunctional status after resection patients supratentorial meningioma aged 80 years or older, identify factors associated outcome, validate previously proposed decision support tool. METHODS: Neurofunctional was assessed by the Karnofsky Performance...
Introduction Chronic subdural haematomas (CSDHs) are one of the most common neurosurgical conditions. The goal surgery is to alleviate symptoms and minimise risk symptomatic recurrences. In past, reoperation rates as high 20%–30% were described for CSDH However, following introduction drainage, dropped approximately 10%. standard surgical technique includes burr-hole craniostomy, followed by intraoperative irrigation placement drainage. Yet, role has not been established. If there no...