Ilkka Haapala
A5007851191- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Advanced Electron Microscopy Techniques and Applications
- Neurosurgical Procedures and Complications
- Music Technology and Sound Studies
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Machine Learning in Materials Science
- Cancer Genomics and Diagnostics
- Thermal Regulation in Medicine
Tampere University Hospital
2019-2024
Tampere University
2019-2024
A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk postoperative thromboembolic and hemorrhagic complications in CSDH with a history AF their association outcome. This posthoc analysis nationwide multicenter randomized controlled trial conducted during 2020-2022 included preoperative AF. incidence associations functional outcomes mortality. Of 589 patients, 128...
Introduction Brain tumors are a major source of disease burden in pediatric population, with the most common tumor types being pilocytic astrocytoma, ependymoma and medulloblastoma. In every entity, surgery is cornerstone treatment, but importance gross-total resection corresponding patient prognosis highly variant. However, real-time identification CNS malignancies based on histology frozen sections alone especially troublesome. We propose novel method differential mobility spectrometry...
OBJECTIVE There is a need for real-time, intraoperative tissue identification technology in neurosurgery. Several solutions are under development that purpose, but their adaptability standard clinical use has been hindered by high cost and impracticality issues. The authors tested preliminarily validated method brain tumor based on the analysis of diathermy smoke using differential mobility spectrometry (DMS). METHODS A DMS connected to special sampling system was used discriminate tumors...
Isocitrate dehydrogenase (IDH) mutation status is an important factor for surgical decision-making: patients with IDH-mutated tumors are more likely to have a good long-term prognosis, and thus favor aggressive resection survival benefit gain. Patients IDH wild-type generally poorer prognosis and, therefore, conservative avoid neurological deficit favored. Current histopathological analysis frozen sections unable identify intraoperatively, advanced methods therefore needed. We examined novel...
Abstract BACKGROUND The first-line treatment for high-grade gliomas (HGG) is maximal safe resection, which limited by diffuse tumor margins and nearby eloquent areas. Intraoperative detection of cells improved with fluorescence-guided surgery using 5-ALA, but its visual blood, obstacles weakness the fluorescence. Aspirate tissue monitoring (ATM) fluorescence from surgical suction waste could improve performance providing objective feedback while maintaining a natural white light anatomical...
Abstract Purpose Extent of brain tumor resection continues to be one the central decisions taken during standard care in glioma patients. Here, we aimed evaluate most essential molecular factors, such as IDH (isocitrate dehydrogenase) mutation gliomas classification with patient-derived organoids (PGOs) using differential mobility spectrometry (DMS). Methods prospectively recruited 12 patients, 6 IDH-mutated and wild-type tumors, from which PGOs were generated ex-vivo . Altogether, 320 DMS...