A5005975812- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Oral microbiology and periodontitis research
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Aortic aneurysm repair treatments
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cerebrovascular and genetic disorders
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Vascular Anomalies and Treatments
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Bacterial Infections and Vaccines
- Inflammatory mediators and NSAID effects
- Complement system in diseases
- Radiomics and Machine Learning in Medical Imaging
- Heme Oxygenase-1 and Carbon Monoxide
Tampere University
2019-2025
Tampere University Hospital
2019-2025
Kuopio University Hospital
2014-2024
University of Eastern Finland
2014-2024
Helsinki University Hospital
2006-2018
Osaka University
2018
Université de Picardie Jules Verne
2018
University of Gothenburg
2018
Juntendo University
2018
Brain (Germany)
2018
Background and Purpose— The cellular mechanisms of degeneration repair preceding rupture the saccular cerebral artery aneurysm wall need to be elucidated for rational design growth factor or drug-releasing endovascular devices. Methods— Patient records, preoperative vascular imaging studies, snap-frozen fundi resected after microsurgical clipping from 66 aneurysms were studied. Immunostainings markers smooth muscle cell (SMC) phenotype, proliferation, inflammatory subtypes TUNEL reaction...
Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in brain vasculature, a leading cause hemorrhagic stroke young adults children. The genetic this rare focal disorder is unknown.
Background and Purpose— Size shape of saccular intracranial aneurysms (sIA) reflect the condition sIA wall were risk factors for rupture in previous follow-up studies. We investigated how well size or identify rupture-prone sIAs. Methods— In a population-based registry, we characteristics ruptured sIAs treated single neurosurgical center (1980–2014). addition to univariate analysis, logistic regression was used multivariate sensitivity specificity calculated using receiver operating...
Saccular cerebral artery aneurysm (SCAA) wall degeneration and inflammatory cell infiltrations associate with rupture subarachnoid hemorrhage, resulting in a devastating form of stroke. The complement system is the key mediator inflammation household processing injured tissue. We studied how activation associates SCAA to better understand pathobiology rupture.Unruptured (n = 26) ruptured 32) fundi resected after microsurgical clipping were by immunostaining for (membrane attack complex...
Inhibition of prostaglandin E 2 signaling in macrophages may be a pharmacological option for treating intracranial aneurysms.
<h3>BACKGROUND AND PURPOSE:</h3> Saccular intracranial aneurysm is a common disease that may cause devastating hemorrhage. Hemodynamics, wall remodeling, and inflammation have been associated with saccular rupture. We investigated how hemodynamics remodeling of the wall. <h3>MATERIALS METHODS:</h3> Tissue samples resected during operation (11 unruptured, 9 ruptured) were studied histology immunohistochemistry. Patient-specific computational models created from preoperative CT angiographies....
Aneurysm hemodynamics has been associated with wall histology and inflammation. We investigated associations between local focal changes visible intraoperatively.Computational fluid dynamics models were constructed from 3D images of 65 aneurysms treated surgically. regions different visual appearances identified in intraoperative videos: 1) "atherosclerotic" (yellow), 2) "hyperplastic" (white), 3) "thin" (red), 4) rupture site, 5) "normal" (similar to parent artery), They marked on...
Brain arteriovenous malformations (bAVMs) are complex, and rare shunts that present with a wide range of signs symptoms, intracerebral hemorrhage being the most severe. Despite prior societal position statements, there is no consensus on management these lesions. ARISE (Aneurysm/bAVM/cSDH Roundtable Discussion With Industry Stroke Experts) was convened to discuss evidence-based approaches enhance our understanding complex identified need develop scales predict risk rupture bAVMs, use common...
The biological mechanisms predisposing intracranial saccular aneurysms to growth and rupture are not yet fully understood. Mural cell loss is a histological hallmark of ruptured cerebral aneurysms. It remains unclear whether mural predisposes aneurysm eventual rupture.Sodium dodecyl sulfate decellularized nondecellularized from syngeneic thoracic aortas were transplanted the abdominal aorta Wistar rats. Aneurysm patency was followed up for 1 month with contrast-enhanced serial magnetic...
Background and Purpose— Shunt dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequela that may lead to poor neurological outcome predisposes various interventions, admissions, complications. We reviewed post-aSAH shunt dependency in population-based sample tested the feasibility of clinical risk score identify subgroups aSAH patients with increasing shunting for hydrocephalus. Methods— A total 1533 from Eastern Finland Saccular Intracranial Aneurysm...
Chronic inflammation contributes to remodeling, degeneration, and rupture of saccular intracranial artery aneurysms. Mast cells are important proinflammatory proangiogenic in chronic inflammatory vascular diseases. Here we studied mast neovascularization 36 intraoperatively resected aneurysms using histology immunohistochemistry analyzed the clinical characteristics according bleeding status (unruptured vs ruptured). Among aneurysms, 9 contained (tryptase-positive cells) 15 neovessels (CD34-...
Saccular intracranial aneurysm (sIA) causes hemorrhages that are associated with high mortality. Lipid accumulation and chronic inflammation occur in the sIA wall. A major mechanism for lipid clearance from arteries is adenosine triphosphate-binding cassette A1 (ABCA1)-mediated efflux foam cells to apolipoprotein A-I (apoA-I). We investigated association of wall degeneration, inflammation, lipid-related parameters tissue samples 16 unruptured 20 ruptured sIAs using histology...
OBJECTIVE: Remodeling of the saccular cerebral artery aneurysm (SCAA) wall, known to be associated with rupture, might modified bioactive endovascular implants or systemic drug therapy targeted at growth factor receptors prevent rupture. The regulating SCAA wall remodeling are, however, unknown. MATERIALS AND METHODS: Immunostaining for 12 receptors, and markers matrix synthesis, proliferation, inflammatory cell infiltration, were analyzed in 21 unruptured 35 ruptured fundi resected after...
We investigated which aneurysm-related risk factors for rupture best discriminate ruptured versus unruptured saccular intracranial aneurysms (sIAs) in subarachnoid hemorrhage patients with multiple sIAs.We included 264 a sIA and at least one additional sIA, from the Kuopio Intracranial Aneurysm database 2003 to 2015. These had 268 445 sIAs. Angiograms of 713 sIAs were reevaluated variables describing aneurysm shape. Multivariate generalized linear mixed models used calculate odds ratios...
BACKGROUND: The cause of rupture intracranial aneurysms (IA) is not well understood. We previously demonstrated that loss cells from the IA wall associated with degeneration and rupture. OBJECTIVE: To investigate mechanisms mediating cell death in wall. METHODS: Snap-frozen tissue samples aneurysm fundi were studied terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining immunostaining (14 unruptured 20 ruptured), as Western blot (12 12 ruptured). RESULTS: Ruptured...
Oral bacteria DNA has been found in intracranial aneurysms (IA) and a high prevalence of periodontitis was reported IA patients. We investigated whether associates with formation aneurysmal subarachnoid hemorrhage (aSAH). First, we compared case-control setting the periodontal disease patients (42 unruptured IA, 34 ruptured IA) age- gender-matched controls (n = 70) from same geographical area (Health 2000 Survey, BRIF8901). Next, at baseline associated aSAH 13-year follow-up study 5170...