A5033441851- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Cardiac electrophysiology and arrhythmias
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Sodium Intake and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Risk Factors
- Oral microbiology and periodontitis research
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Dementia and Cognitive Impairment Research
- Liver Disease and Transplantation
- Psychosomatic Disorders and Their Treatments
- Cardiac Arrhythmias and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- ECG Monitoring and Analysis
- Fatty Acid Research and Health
Finnish Institute for Health and Welfare
2016-2025
University of Turku
2013-2024
Turku University Hospital
2013-2024
FinnMedi (Finland)
2024
Public Health Solutions
2018-2023
KU Leuven
2012-2023
University of Abuja
2016-2023
Hospital Italiano de Buenos Aires
2016-2023
Universidad de la República
2023
Hospital de Clínicas
2023
In Finland, coronary heart disease (CHD) incidence was very high in the 1960s and 1970s. line with this incidence, Seven Countries Study showed that level of serum cholesterol Finns also highest among investigated countries 1960s. Because several studies indicated atherosclerotic process starts early life, accord World Health Organization Recommendation 1978 which stated assessing atherosclerosis precursors children should be initiated, a program launched Finland late 1970s to study...
Background— High-throughput profiling of circulating metabolites may improve cardiovascular risk prediction over established factors. Methods and Results— We applied quantitative nuclear magnetic resonance metabolomics to identify the biomarkers for incident disease during long-term follow-up. Biomarker discovery was conducted in National Finnish FINRISK study (n=7256; 800 events). Replication incremental assessed Southall Brent Revisited (SABRE) (n=2622; 573 events) British Women’s Health...
Previous studies with some limitations have provided equivocal results for the prognostic significance of home-measured blood pressure (BP). We investigated whether BP is more strongly associated cardiovascular events and total mortality than office BP. A prospective nationwide study was initiated in 2000 to 2001 on 2081 randomly selected subjects aged 45 74 years. Home were determined at baseline along other risk factors. The primary end point incidence a event (cardiovascular mortality,...
Home blood pressure monitoring is useful in detecting white-coat and masked hypertension recommended for patients with suspected or treated hypertension. The prognostic significance of detected by home measurement was investigated 6458 participants from 5 populations enrolled the International Database HOme relation to Cardiovascular Outcomes. During a median follow-up 8.3 years, 714 fatal plus nonfatal cardiovascular events occurred. Among untreated subjects (n=5007), risk higher those...
The objective of the study was to assess prognostic value variability in home-measured blood pressure (BP) and heart rate (HR) a general population. We studied representative sample Finnish adult population with 1866 subjects aged 45-74 years. BP HR self-measurements were performed on 7 consecutive days. variabilities defined as SDs morning minus evening, day-by-day, first second measurements. primary end point incidence cardiovascular event. secondary total mortality. During follow-up 7.8...
The metabolic syndrome and alcohol risk use are both associated with a high prevalence of hepatic steatosis, but only minority develop liver failure or cancer. Few general population studies have analyzed predictors such severe complications. We studied which factors best predict complications, stratified by consumption, in 6732 individuals without baseline disease who participated the Finnish population‐based Health 2000 Study (2000‐2001), nationally representative cohort. Follow‐up data...
Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive this disease, but quality may also contribute. Here, we focused on intrinsic propensity to aggregate upon modification. We examined whether inter-individual differences in are linked with lipid composition coronary artery (CAD) death, basic mechanisms for plaque growth...
Even though the association between alexithymia and somatization seems plausible according to several studies with selected populations, it has not been verified in carefully controlled nationally representative population studies. We conducted such a study find out whether is associated at level.This was part of Finnish Health 2000 Study. The sample comprised 5129 subjects aged 30 97 years. Alexithymia measured 20-item Toronto Scale (TAS-20) somatic symptom reporting 12-item scale derived...
The aim of this study is to evaluate whether childhood risk factors are associated with a 6-year change in carotid intima-media thickness (IMT) young adulthood independent the current factors. Cardiovascular Risk Young Finns cohort consisted 1809 subjects who were followed-up for 27 years since baseline (1980, age 3–18 years) and having IMT measured both 2001 2007. assessed repeatedly childhood. A genotype score was calculated using 17 newly identified genetic variants associating...
OBJECTIVE Metabolite predictors of deteriorating glucose tolerance may elucidate the pathogenesis type 2 diabetes. We investigated associations circulating metabolites from high-throughput profiling with fasting and postload glycemia cross-sectionally prospectively on population level. RESEARCH DESIGN AND METHODS Oral was assessed in two Finnish, population-based studies consisting 1,873 individuals (mean age 52 years, 58% women) reexamined after 6.5 years for 618 one cohorts. Metabolites...
ContextLimited information exists on the interaction between diet and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) interaction's effect serum lipid lipoprotein levels, insulin sensitivity, circulating antioxidant vitamin provitamin levels.ObjectiveTo evaluate separate combined effects of simvastatin therapy levels lipids, lipoproteins, antioxidants, insulin.Design, Setting, ParticipantsRandomized, controlled crossover trial conducted from August 1997 to June 1998 in...
Shoulder pain is a common health problem. The purpose of this study was to assess the associations lifestyle factors, metabolic factors and carotid intima-media thickness with shoulder chronic (> 3 months) rotator cuff tendinitis.In cross-sectional study, target population consisted subjects aged 30 years or older participating in national Finnish Health Survey during 2000-2001. Of 7,977 eligible subjects, 6,237 (78.2%) participated structured interview clinical examination. Chronic...
Background— Atherosclerosis development might be delayed or prevented by dietary measures. The aims of the present study were to evaluate effect low-saturated-fat, low-cholesterol counseling on fat intakes, growth, serum cholesterol values, and pubertal in children adolescents. Methods Results— In randomized prospective Special Turku Coronary Risk Factor Intervention Project (STRIP), a diet was introduced intervention infants (n=540) at 7 months age, control (n=522) received an unrestricted...
AimsHigh-throughput metabolite quantification holds promise for cardiovascular risk assessment. Here, we evaluated whether by nuclear magnetic resonance (NMR) improves prediction of subclinical atherosclerosis in comparison to conventional lipid testing.
Background— In the Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study, repeated dietary counseling introduced in infancy and maintained until 20 years of age has led to lower intakes saturated fat serum low-density lipoprotein cholesterol. this we examined prospectively intervention effects on ideal cardiovascular health concept recently described by American Heart Association. Additionally, investigated association between vascular intima-media thickness...
Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors predict adult hypertension furthermore whether newly identified genetic variants for blood pressure increase prediction hypertension.The cohort included 2625 individuals from Cardiovascular Risk in Young Finns Study who were followed up 21 27 years since baseline (1980; age, 3-18 years). In addition dietary...
Background and Aims The effects of alcohol use in nonalcoholic fatty liver disease are unclear. We investigated the impact on incident liver, cardiovascular, malignant disease, as well death. Approach Results Our study comprised 8,345 persons with hepatic steatosis (fatty index >60) who participated health‐examination surveys (FINRISK 1992‐2012 or Health 2000), available data baseline intake. Main exclusions were clinical viral hepatitis, ethanol intake >50 g/day, current abstainers....