A5075912804- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Obesity and Health Practices
- Diabetes Management and Education
- Diet and metabolism studies
- Health Promotion and Cardiovascular Prevention
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Physical Activity and Health
- Eating Disorders and Behaviors
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Tryptophan and brain disorders
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
- Health, psychology, and well-being
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Birth, Development, and Health
- Sleep and related disorders
University of Eastern Finland
2013-2022
Kuopio University Hospital
2010-2019
Central Finland Health Care District
2010-2019
Finland University
2010-2018
Eastern Finland Laboratory Center
2015
University of Jyväskylä
2012
Laurea University of Applied Sciences
2004-2009
FishBase Information and Research Group
2007
Pirkanmaa Hospital District
1998-1999
Background Music therapy has previously been found to be effective in the treatment of depression but studies have methodologically insufficient and lacking clarity about clinical model employed. Aims To determine efficacy music added standard care compared with only among working-age people. Method Participants ( n = 79) an ICD–10 diagnosis were randomised receive individual plus (20 bi-weekly sessions) or only, followed up at baseline, 3 months (after intervention) 6 months. Clinical...
In this study, the authors analyzed whether chronotypes, sleep duration, and sufficiency are associated with cardiovascular diseases type 2 diabetes by using National FINRISK Study 2007 data (N = 6258), being a representative sample of population aged 25 to 74 living in five areas Finland. Health status assessments laboratory measurements from participants 4589) DILGOM substudy were used for detailed analysis chronotype. Evening types had 2.5-fold odds ratio (p < .01) as compared morning...
OBJECTIVE To investigate 1-year outcomes of a national diabetes prevention program in Finland. RESEARCH DESIGN AND METHODS Altogether 10,149 individuals at high risk for were identified with the Finnish Diabetes Risk Score (FINDRISC; scoring ≥15 points), by history impaired fasting glucose (IFG) or tolerance (IGT), cardiovascular disease, gestational mellitus 400 primary health care centers. One-year follow-up data available 2,798 participants who nondiabetic baseline (919 men and 1,879...
Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine what extent elevated body mass index (BMI) within the normal weight range has causal effects on detailed systemic metabolite profile in early adulthood. Methods and Findings used Mendelian randomization estimate of BMI 82 metabolic measures 12,664 adolescents young adults from four population-based cohorts Finland (mean age 26 y, 16–39 y; 51% women; mean ± standard deviation 24±4...
Long-term physical inactivity seems to cause many health problems. We studied whether persistent activity compared with has a global effect on serum metabolome toward reduced cardiometabolic disease risk.Sixteen same-sex twin pairs (mean age, 60 years) were selected from cohort of the basis their >30-year discordance for activity. Persistently (≥5 active and inactive groups in 3 population-based cohorts ages, 31-52 also (1037 age- sex-matched pairs). Serum was quantified by nuclear magnetic...
Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. This study sought to determine the molecular of statin on multiple metabolic pathways. Metabolic profiles based serum nuclear magnetic resonance metabolomics were quantified at 2 time points in 4 population-based cohorts from United Kingdom Finland (N = 5,590; 2.5 23.0 years follow-up)....
Most researchers agree that obesity is an important modulator of the metabolic syndrome, 1 2 which a clustering cardiovascular risk factors associated with insulin resistance-such as hypertension, hypertriglyceridaemia, low concentration high density lipoprotein cholesterol, abnormal glucose metabolism, and hyperinsulinaemia. 3 Little known, however, about association between relative weight change from childhood to adulthood development syndrome in adulthood.
Objectives. Current evidence shows that type 2 diabetes (T2D) can be prevented by life-style changes and medication. To meet the menacing epidemic, there is an urgent need to translate scientific regarding prevention of T2D into daily clinical practice public health. In Finland, a national programme for has been launched. The comprises 3 concurrent strategies prevention: population strategy, high-risk strategy early diagnosis management. article describes implementation T2D.Methods. project,...
OBJECTIVE Metabolite predictors of deteriorating glucose tolerance may elucidate the pathogenesis type 2 diabetes. We investigated associations circulating metabolites from high-throughput profiling with fasting and postload glycemia cross-sectionally prospectively on population level. RESEARCH DESIGN AND METHODS Oral was assessed in two Finnish, population-based studies consisting 1,873 individuals (mean age 52 years, 58% women) reexamined after 6.5 years for 618 one cohorts. Metabolites...
Article AbstractObjective: Previous cross-sectional studies have suggested that patients with depression a high risk for metabolic syndrome. As there is paucity of data concerning the temporal relationship and syndrome, we decided to evaluate developing depressive symptoms in syndrome population-based follow-up study. Method: The prevalence at baseline 1998 7-year 2004/2005 was studied large, middle-aged, sample collected from Central Finland. Depressive were measured Beck Depression...
The aim of this work was to examine the prevalence different metabolical phenotypes obesity, and analyze, by using risk scores, how metabolic syndrome (MetS) definition discriminates between unhealthy healthy in obesity classes. Finnish type 2 diabetes (FIN-D2D) survey, a part larger implementation study, carried out 2007. present cross-sectional analysis comprises 2,849 individuals aged 45-74 years. MetS defined with new Harmonization definition. Cardiovascular estimated Framingham SCORE...
Objective: To evaluate the risk for developing metabolic syndrome when having depressive symptoms. Method: The prevalence of symptoms and at baseline, after a 7‐year follow‐up as measured with Beck depression inventory (BDI), using modified National Cholesterol Education Program – Adult Treatment Panel III criteria (MetS) were studied in middle‐aged population‐based sample ( n = 1294). Results: logistic regression analysis showed 2.5‐fold (95% CI: 1.2–5.2) females (BDI ≥10) baseline to have...
Disturbances in lipid metabolism have been linked to suicidal behaviour, but little is known about the association between suicide risk and abnormal glucose depression. Hyperglycaemia hyperinsulinaemia may increase of depression also for suicide, we therefore studied associations behaviour disturbances depressive patients who had referred nurse case managers.Patients aged 35 years older (N = 448, mean age 51 years) were experiencing a new episode, managers 2008-2009 scored ≥10 on Beck...
To evaluate sex hormones in premenopausal white women with metabolic syndrome (MBS).Cross-sectional controlled community-based study.Pieksämäki District Health Center, Pieksämäki, Finland.Five hundred forty-three women, aged 34 to 54 years, were screened according National Cholesterol Education Program criteria: waist >88 cm, hypertension >/=130/>/=85 mm Hg, hypertriglyceridemia >/=1.7 mmol/L, high-density lipoprotein (HDL)-cholesterol <1.3 and fasting glucose >/=6.1 mmol/L. Sixty-three...
There is a worldwide increase in the prevalence of obesity and disturbances glucose metabolism. The aim this study was to assess current obesity, central abnormal tolerance Finnish population, investigate associations between body mass index (BMI), waist circumference tolerance. A cross-sectional population-based survey conducted Finland during October 2004 January 2005. total 4500 randomly selected individuals aged 45–74 years were invited health examination that included an oral test....
Increased ferritin concentrations are associated with metabolic syndrome (MetS). The association between as well hemoglobin level and individual MetS components is unclear. Erythropoietin levels in subjects have not been determined previously. aim of this study was to compare serum erythropoietin, ferritin, haptoglobin, hemoglobin, transferrin receptor (sTFR) without components.A population based cross-sectional 766 Caucasian, middle-aged (341 men 425 women) from five age groups born...
To examine prospectively the association of psychological distress with development metabolic syndrome (MetS) and potential influence demographic characteristics, health behaviors, inflammation in this association.A total 466 (n = 185 males; 281 females) subjects, aged 36 to 56 years, free MetS at baseline, participated a population-based study from 1997 1998 again 2004 2005. Mean observation time was 6.4 years. Various clinical, biochemical, behavioral factors were measured including...
To examine whether persons with psychological distress have a greater risk of all-cause mortality in the Scandinavian population; this association is gender-specific; and what influence socioeconomic status, body mass index (BMI) health behaviour association.A total 923 (414 male 509 female) people, aged 36 to 56 years, participated population-based study from 1997-98 Pieksämäki, Finland. Psychological was measured using 12-item General Health Questionnaire (GHQ-12). The GHQ-12 points were...
An association between vitamin B12 levels and depressive symptoms (DS) has been reported in several epidemiological studies. The purpose of this study was to evaluate population-based samples with melancholic or non-melancholic DS as the relationship different subtypes not evaluated previous Subjects without previously known type 2 diabetes, aged 45–74 years were randomly selected from National Population Register a part Finnish diabetes prevention programme (FIN-D2D). population (N = 2806,...
We explored gender differences in the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra) and adiponectin with metabolic syndrome (MetS) defined by National Cholesterol Education Program (NCEP) International Diabetes Federation (IDF) criteria.A population-based study 923 middle-aged subjects Pieksämäki, East Finland.The prevalence MetS according to IDF NCEP definitions was 38% 34% men (N = 405) 27% women 497), respectively. hs-CRP IL-1Ra...