A5048162275- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Nutritional Studies and Diet
- Amino Acid Enzymes and Metabolism
- Cardiovascular Health and Disease Prevention
- Metabolism and Genetic Disorders
- Gestational Diabetes Research and Management
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Risk Factors
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Nutrition, Genetics, and Disease
- Breastfeeding Practices and Influences
Turku University Hospital
2016-2025
University of Turku
2016-2025
Office of Adolescent Health
2020
Kainuun keskussairaala
2018
Finnish Institute for Health and Welfare
2013-2017
Murdoch Children's Research Institute
2015
Paavo Nurmen Säätiö
2015
University of Tasmania
2015
University of Helsinki
1999-2014
Fimlab (Finland)
2014
Background— Atherosclerosis development might be delayed or prevented by dietary measures. The aims of the present study were to evaluate effect low-saturated-fat, low-cholesterol counseling on fat intakes, growth, serum cholesterol values, and pubertal in children adolescents. Methods Results— In randomized prospective Special Turku Coronary Risk Factor Intervention Project (STRIP), a diet was introduced intervention infants (n=540) at 7 months age, control (n=522) received an unrestricted...
Background— In the Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study, repeated dietary counseling introduced in infancy and maintained until 20 years of age has led to lower intakes saturated fat serum low-density lipoprotein cholesterol. this we examined prospectively intervention effects on ideal cardiovascular health concept recently described by American Heart Association. Additionally, investigated association between vascular intima-media thickness...
Impairment of vascular endothelial function and increased intima-media thickness (IMT) are important early steps in atherogenesis. Longitudinal data on the effect physical activity IMT healthy adolescents lacking. We investigated prospectively association leisure-time with (brachial artery flow-mediated dilatation; FMD) aortic adolescents.FMD were measured ultrasonography at 13 (n=553), 15 (n=531), 17 (n=494) years age participating a longitudinal atherosclerosis prevention study (Special...
Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating trajectories remain largely unknown. Here, we modeled longitudinal height Super-Imposition by Translation And Rotation (SITAR) curve analysis on ~ 56,000 trans-ancestry samples repeated measurements from age 5 years to adulthood. We performed six phenotypes representing magnitude, timing, and intensity of pubertal spurt. To investigate lifelong impact variants associated trajectories,...
Sepsis is the most common morbidity in preterm infants, who often receive total parenteral nutrition (TPN). We hypothesized that gut barrier function compromised TPN-fed compared with enterally fed newborn piglets (ENT pigs). Colostrum-deprived pigs were implanted jugular venous and bladder catheters under general anesthesia. Pigs either administered TPN ( n = 15) or formula pigs, 15). After 6 days, gavaged a solution of mannitol, lactulose, polyethylene glycol 4000 (PEG 4000) urine was...
It is now clear that atherosclerosis develops as a result of life-long process often leading to coronary heart disease. Nutritional recommendations have been delivered the general community manage this epidemic. Since fat an important source energy and cholesterol required for sex hormone synthesis, fears emerged low intake saturated might influence children’s growth development. Infants young children therefore excluded from these nutritional recommendations. However, number arguments...
Blood pressure was measured in the prospective randomized Special Turku Coronary Risk Factor Intervention Project Study with an oscillometric method every year from 7 months to 15 years of age 540 children receiving a low-saturated-fat, low-cholesterol diet and 522 control children. Dietary intakes, family history parental hypertension, grandparental vascular disease were recorded. Systolic diastolic blood pressures 1.0 mm Hg lower (95% CI for systolic: −1.7 −0.2 Hg; 95% diastolic: −1.5 −0.4...
Abstract Background Long‐term survivors of childhood acute lymphoblastic leukemia (ALL) have increased risk cardiovascular disease (CVD). The prevalence insulin resistance and other cardiometabolic factors is in ALL survivors, insufficient physical activity (PA) low cardiopulmonary fitness are common. purpose this study was to evaluate the effects a simple, inexpensive home‐based exercise program on long‐term survivors. Procedure Seventeen 16‐ 30‐year‐old (age at diagnosis ≤16 years) were...
Background— Adolescent metabolic syndrome (MetS) predicts type 2 diabetes mellitus and subclinical atherosclerosis in adulthood. Our aim was to establish the relationship between an infancy-onset dietary intervention risk of having MetS 15 20 years age. Methods Results— The Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study is a longitudinal, randomized prevention trial which repeated counseling aiming at reducing intake saturated fat took place from infancy...
Abstract —Measures of arterial elasticity have been proposed as surrogate markers for asymptomatic atherosclerosis. We investigated the relations serum lipoproteins, oxidized low-density lipoprotein (ox-LDL), and familial hypercholesterolemia (FH) to among young men. As a marker we measured compliance in thoracic aorta by using magnetic resonance imaging common carotid artery ultrasound. LDL diene conjugation was used ox-LDL. In study I, 25 healthy men (aged 29 39) were classified into 2...
The purpose of this study was to examine patterns physical activity (PA) during a single weekend ascertain possible relationships between PA and anthropometry, fundamental motor skills, CHD risk factors among 105 normal male female children, aged 3–4 years. children played, when awake, on the average for 14 hr, 16 min indoors 5 12 outdoors which low playing accounted about 4 hr. Notable gender differences were observed in intensity but not skills factors. results suggest that is weakly...
Background The long-term consequences of modified fat intake in early childhood are poorly known. randomized prospective STRIP baby project evaluates the effects repeated dietary counseling on nutrient intakes and serum lipid values children 7 months to 3 years old. Methods Results One thousand sixty-two infants were intervention control groups at age. families 540 counseled reduce child's saturated cholesterol but ensure adequate energy intake. Five hundred twenty-two consumed an...
Background— Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children’s serum total cholesterol concentration, but its effect on vascular endothelial function is unknown. Methods and Results— Between 1990 1992, we randomized healthy 7-month-old infants (n=1062) to intervention (low-saturated-fat diet) control (unrestricted groups. At the age 11 years, endothelium-dependent (flow-mediated) endothelium-independent (nitrate-mediated) vasodilatory...