A5070804993- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Axon Guidance and Neuronal Signaling
- Neurosurgical Procedures and Complications
- Ophthalmology and Eye Disorders
- Neuroscience of respiration and sleep
- Mental Health and Psychiatry
- Cerebral Venous Sinus Thrombosis
- Nicotinic Acetylcholine Receptors Study
- Atomic and Subatomic Physics Research
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Healthcare Decision-Making and Restraints
- Psychiatric care and mental health services
- Retinal Development and Disorders
- Cellular transport and secretion
University of Turku
2011-2021
Turku University Hospital
2020-2021
St George Hospital
2007
University of Skövde
1991
University College London
1980-1986
National Institute for Medical Research
1979
University of Oxford
1976
Monash University
1968-1971
1. The mechanism responsible for the elimination of polyneuronal innervation in developing rat soleus muscles was studied electrophysiologically and histologically. 2. Initially all axons contacting a single end-plate have simple bulbous terminals. As proceeds one axon develops terminal branches while other terminals remain may be seen contact with, or short distance away from, end-plate. It is suggested that branched remains with muscle fibre withdraw. 3. At time when can no longer detected...
1. A quantitative analysis has been made of the characteristics granular vesicles in different parts normal and ligated post‐ganglionic sympathetic neurones supplying cat spleen. The least diameter vesicle membrane its electron‐dense core was measured from electron micrographs with an automated particle size analyser. 2. Vesicles average 443 Å, without cores (192 Å), were concentrated axon terminals spleen, whereas cell bodies coeliac ganglion their axons there only a few large (787 Å)...
ABSTRACT The modes of retinal and tectal histogenesis, as well the patterns terminal distribution optic axons in larval Xenopus were studied, using anatomical techniques. We show that retina grows by adding strips cells at its ciliary margin. pattern growth is asymmetrical along dorso-ventral axis retina. On other hand, tectum newly formed caudo-medially. most rapid takes place between stages 50 53, thereafter only a small proportion are added near midline caudal tectum. Despite such...
A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk postoperative thromboembolic and hemorrhagic complications in CSDH with a history AF their association outcome. This posthoc analysis nationwide multicenter randomized controlled trial conducted during 2020-2022 included preoperative AF. incidence associations functional outcomes mortality. Of 589 patients, 128...
Summary The effects of a single dose 6‐hydroxydopamine (6‐OHDA) compared with those chronic reserpine treatment were studied in lamb sympathetic neurones and adrenal medulla by combination fluorescence histochemistry, electron microscopy radiochemical assay. In ganglia, 6‐OHDA produced rise noradrenaline concentration within 24 h, falls tyrosine hydroxylase monoamine oxidase activities, whereas caused fall noradrenaline, activity no change activity. intra‐ postganglionic axons increased...
There is evidence that the cholinergic system frequently involved in cognitive consequences of traumatic brain injury (TBI). We studied whether function altered after TBI vivo using PET.Cholinergic was assessed with [methyl-(11)C]N-methylpiperidyl-4-acetate, which reflects acetylcholinesterase (AChE) activity, 17 subjects more than 1 year a and 12 healthy controls. All had been without any centrally acting drugs for at least 4 weeks.The AChE activity significantly lower compared to controls...
The effects of pinealectomy and superior cervical ganglionectomy on the testis vole (Microtus agrestis) were studied. Testicular weight at 4 8 weeks was significantly (p less than .001) greater in pinealectomized ganglionectomized controls animals. Similar results found weights seminal vesicles. Seminiferous tubule diameters also increased, spermatogenesis stimulated. Spermatogenic development had preceeded only to meiotic phase. indicate that pineal gland is involved light-induced gonadal...
There is evidence that the cholinergic system involved in cognitive sequels of traumatic brain injury (TBI). Nicotinic acetylcholine receptors (nAChRs) are known to have a major role functions. Smokers up-regulation these receptors. This study investigated whether smoking associated with outcome from TBI.A specific questionnaire was sent, after checking inclusion and exclusion criteria, 1022 subjects TBI who had visited neurological outpatient clinic university hospital during 14-year...
To investigate quantitative positron emission tomography (PET) findings and to study whether the cholinergic function differs between respondents medication versus nonrespondents.Outpatient clinic university PET imaging center.We studied 17 subjects for more than 1 year after at least moderate traumatic brain injury. Ten of were 7 nonrespondents medication.Cholinergic was assessed with [methyl-C] N-methylpiperidyl-4-acetate-PET (C-MP4A-PET), which reflects activity acetylcholinesterase...
Fifty‐eight patients with intraocular hypertension or primary open angle glaucoma participated in a double masked randomized study. Timolol concentrations 0.25% and 0.5% was compared 1, 2, 4% pilocarpine. Acetazolamide (250 mg × 3) added if pressure (IOP) uncontrolled the highest tested. No statistical difference found hypotensive effect between pilocarpine timolol neither on ocular hypertensions nor glaucomas. The additive of acetazolamide same for both substances. Once day administration...
Abstract. 1573 examinations were performed on 397 eyes. hh was found in 55 eyes ‐ thromboses included at 91 examinations. Part of this material qualified for use a comparative study with pilocarpine 81 and timolol 82 The relative frequency the treated groups pretreatment group not significantly different from that whole material. No indication pressure reduction effect occurrence could be detected. average probability an examination chosen random 6 per cent ordinary simple capsular glaucoma...
The cholinergic nuclei in the basal forebrain innervate frontal cortical structures regulating attention. Our aim was to investigate if cognitive test results measuring attention relate longitudinal volume change of cholinergically innervated following traumatic brain injury (TBI). During prospective, observational TBIcare project patients with all severities TBI (n = 114) and controls acute orthopedic injuries 17) were recruited. Head MRI obtained both (mean 2 weeks post-injury) late 8...
Glomuvenous malformations (MIM 138000) are rare vascular consisting of glomus cells, and in affected individuals, lesions may appear any number anywhere on the body. We analysed DNA one family with hereditary glomuvenous identified mutation causing disease glomulin gene chromosome 1 p22. The deletion started at base pair 157: 157delAAGAA, which is a five pairs. This has been found Europe, USA Australia, suggesting founder effect common ancestry. Thus far, no second-hit for 157delAAGAA identified.
The diagnosis of mild traumatic brain injury (TBI) is challenging in the acute setting because symptoms are nonspecific and often transient, or they develop with a delay. In these cases, criteria for head imaging frequently not fulfilled. This may lead to missed diagnoses emergency care. There need developing rapid diagnostic test verify presence TBI using body fluids. Blood, urine, saliva samples from 11 adult patients (mean age 64 years, SD 24 years) clinically diagnosed TBI, 12 healthy...
SUMMARY Adult female albino rats were exposed to constant light after either a sham operation or bilateral removal of the cervical sympathetic chain. The second was later shown have resulted in disappearance all fluorescent fibres from pineal gland. Despite denervation pineal, there no delay onset persistent vaginal cornification and significant differences ovarian weight, sexual receptivity, incidence ovulation mating number eggs ovulated between two groups.