A5049422126- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Eicosanoids and Hypertension Pharmacology
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Signaling Pathways in Disease
- Sleep and Wakefulness Research
- Cholinesterase and Neurodegenerative Diseases
- Photoreceptor and optogenetics research
- Cytokine Signaling Pathways and Interactions
Case Western Reserve University
2012-2024
Center for Southeast Asian Studies
2022
Harvard University
1986-2013
Center for Neurosciences
1988-2013
University School
1991-2010
Neurosciences Institute
1999-2007
Boston Children's Hospital
2002
Weatherford College
2001
Brigham and Women's Hospital
1993
Harvard University Press
1978-1987
Horseradish peroxidase (HRP) was used to determine the location in spinal cord of neurons projecting superior cervical ganglion rat. HRP applied proximal cut end sympathetic trunk, close its entry into ganglion. After survival times 3, 6, or 9 days, animals were sacrificed and their cords processed visualize using diaminobenzidine, benzidine dihydrochloride, tetramethylbenzidine. Labeled found only ipsilateral site application restricted segments C8-T5. Ninety percent these located T1-T3....
Macrophages have been implicated in peripheral nerve regeneration for some time, supposedly through their involvement Wallerian degeneration, the process by which distal degenerates after axotomy and is cleared phagocytosis. Thus, several studies macrophage accumulation was reduced degeneration inhibited, delayed. However, this interpretation ignores more recent findings that macrophages also accumulate around axotomized cell bodies. The function of action at second site has not clear. In...
Abstract —Cell nuclei were isolated from four regions of the brains ovariectomized female rats 2 hr after injection [ 3 H]oestradiol. By light microscopy, nuclear pellets contained highly purified neuronal and glial cells with little cytoplasmic contamination. Tritium was concentrated in cell preoptic‐hypothalamic area, to a lesser extent amygdaloid region hippocampus, least all cerebral cortical nuclei. In comparison whole homogenates (= 1‐0), concentrations radioactivity 12·9, 4·7, 1·9...
Abstract Horseradish peroxidase (HRP) was used to determine whether neurons in the rat superior cervical ganglion (SCG) are localized regions of as a function postganglionic trunk they utilize. In separate experiments, each two major trunks cut 1–3 mm from SCG and solid HRP applied end proximal ganglion. The results demonstrated that cell bodies whose axons project out internal carotid nerve (ICN) were located primarily rostral part Cell external (ECN) caudal part. total percentages with ICN...
Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In peripheral nervous system, infiltrating monocyte-derived macrophages, which use chemokine receptor CCR2 gain entry injured tissues from bloodstream, are purportedly necessary for efficient WD. However, our laboratory has previously reported that myelin clearance in sciatic nerve proceeds unhindered Ccr2 −/− mouse model. Here, we extensively characterize WD male mice and identify...
Neonatally castrated male rats showed feminine behavior in- creases (compared with littermates as adults) during testosterone-progesterone and estrogen treatments well estrogen-progesterone treatment. They also masculine deficits control castrates) testosterone androgenized female were less receptive than litter- mate controls under all hormone treatments: testosterone-progesterone, estrogen, estrogen-progesterone. not different in tests from females. These observations rule out the...
Axonal transection of adult sympathetic and sensory neurons leads to a decrease in their content target-derived nerve growth factor (NGF) dramatic changes the expression several neuropeptides enzymes involved transmitter biosynthesis. For example, axotomy superior cervical ganglion (SCG) dramatically increases levels galanin, vasoactive intestinal peptide (VIP), substance P respective mRNAs decreases mRNA for neuropeptide Y (NPY) tyrosine hydroxylase (TH). Axotomy lumbar dorsal root ganglia...
Androgen-concentrating cells were found in the midbrain of chaffinch Fringilla coelebs by autoradiography using tritiated testosterone. Labeled localized primarily nucleus intercollicularis, an area from which vocalizations can be electrically stimulated birds. These autoradiographic results suggest that intercollicularis is a site action androgens on avian vocal behavior.
Adult peripheral neurons, in contrast to adult central are capable of regeneration after axonal damage. Much attention has focused on the changes that accompany this two places, distal nerve segment (where phagocytosis debris, surface properties Schwann cells, and induction growth factors cytokines occur) neu-ronal cell body, where dramatic morphology gene expression occur. The axotomized body often referred as "cell response". focus current review is a family cytokines, gp130 which have...
Neuroinflammation accompanies neural trauma and most neurological diseases. Axotomy in the peripheral nervous system (PNS) leads to dramatic changes injured neuron: cell body expresses a distinct set of genes known as regeneration-associated genes, distal axonal segment degenerates its debris is cleared, axons proximal form growth cones extend neurites. These processes are orchestrated part by immune other non-neuronal cells. Macrophages ganglia play an integral role supporting regeneration....