A5073927339- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Craniofacial Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Head and Neck Surgical Oncology
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and genetic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Atrial Fibrillation Management and Outcomes
- Immune cells in cancer
- Cardiovascular Health and Disease Prevention
- Global Health and Surgery
Helsinki University Hospital
2022-2024
University of Helsinki
2018-2024
Abstract Introduction Globally, many regions have an urgent, unmet need of neurosurgical care. A multi-step twinning technique, International Neurosurgical Twinning Modeled for Africa (INTIMA), was proved to be successful during a previous mission Unit, Enugu, Nigeria. The Swedish African Collaboration (SANC) performed developmental together with the local unit in Gambia, adopting INTIMA model. Methods multidisciplinary team visited 2-week collaborative at Department Edward Francis Small...
A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk postoperative thromboembolic and hemorrhagic complications in CSDH with a history AF their association outcome. This posthoc analysis nationwide multicenter randomized controlled trial conducted during 2020-2022 included preoperative AF. incidence associations functional outcomes mortality. Of 589 patients, 128...
Introduction: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention the most cost-effective therapy, antiplatelet and cholesterol-lowering drugs have a ceiling effect in their efficacy. Therefore, discovery of novel pathophysiologic targets are needed to improve primary secondary stroke. This article provides detailed study design protocol HeCES2, observational prospective cohort with objective investigate...
Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for prevention of venous thrombosis and thromboembolism. However, antagonists may promote arterial calcification, a phenomenon that has been previously studied in coronary peripheral arteries, but not extracranial carotid arteries. In this observational cohort study, we investigated whether associated calcification atherosclerotic Methods: Overall, 500 consecutive patients underwent endarterectomy, 82 whom...
Glutamine synthetase (GLUL), the sole generator of glutamine, is a metabolic nexus molecule also involved in atherosclerosis. We recently demonstrated 2.2-fold upregulation GLUL mRNA stroke-causing carotid plaques when compared with from asymptomatic patients. Here we same cohort expression plaque gross morphology, and colocalization immunodetectable protein histopathological changes molecular mechanical mediators linked to development.Endarterectomy specimens 19 24 stroke patients were...