A5103274390- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Mast cells and histamine
- Acute Ischemic Stroke Management
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Angiogenesis and VEGF in Cancer
- Fatty Acid Research and Health
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Health Promotion and Cardiovascular Prevention
- Lipid metabolism and disorders
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Cerebrovascular and genetic disorders
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
University of Helsinki
2017-2021
Wihuri Research Institute
2007-2011
Activated mast cells (MCs) induce endothelial cell (EC) apoptosis in vitro and are present at sites of plaque erosions vivo. To further elucidate the role MCs consequently erosion, we have studied molecular mechanisms involved MC-induced EC apoptosis.Primary cultures rat cardiac microvascular ECs (RCMECs) human coronary artery (HCAECs) were treated either with MC releasate (ie, mediators released on activation), chymase tumor necrosis factor-alpha (TNF-alpha), or TNF-alpha, respectively....
Abstract Accumulating in vitro and vivo studies have proposed a role for mast cells the pathogenesis of atherosclerosis. Here, we studied lipoprotein metabolism, key element atherosclerotic disease. Male mice deficient low‐density receptors on Western diet 26 weeks had significantly less changes both aortic sinus (55%, P = 0.0009) aorta (31%, 0.049), as compared to cell‐competent littermates. Mast cell‐deficient female (43%, 0.011). Furthermore, found significant positive correlation between...
Bradykinin type 2 receptor (BK-2R) knockout mice develop microvascular dysfunction and cardiac hypertrophy. In aged human endothelium, develops before heart failure symptoms. Since endothelial aging is an independent risk factor for cardiovascular disease, we aimed to clarify the role of kinin receptors in age-related senescence.Using qRT-PCR, a downregulation BK-2Rs during senescence cultured coronary artery cells (HCAECs) rat (RCMECs) was observed. BK-2R associated with decreased cell...
Introduction: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention the most cost-effective therapy, antiplatelet and cholesterol-lowering drugs have a ceiling effect in their efficacy. Therefore, discovery of novel pathophysiologic targets are needed to improve primary secondary stroke. This article provides detailed study design protocol HeCES2, observational prospective cohort with objective investigate...
Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for prevention of venous thrombosis and thromboembolism. However, antagonists may promote arterial calcification, a phenomenon that has been previously studied in coronary peripheral arteries, but not extracranial carotid arteries. In this observational cohort study, we investigated whether associated calcification atherosclerotic Methods: Overall, 500 consecutive patients underwent endarterectomy, 82 whom...
Loss of endothelial cells (ECs) with ensuing exposure thrombogenic subendothelial surface is a common cause thromboembolic complications in atherosclerotic arteries. Thus, denudation has emerged as major contributor to the pathogenesis atherosclerosis and its complications. Despite ongoing efforts elucidating erosions human arteries, mechanisms erosion have remained enigmatic, partly due lack well-established methods for identification. Here authors point out plausible pitfalls current...