A5061853006- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Single-cell and spatial transcriptomics
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
- Takotsubo Cardiomyopathy and Associated Phenomena
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Cerebral Venous Sinus Thrombosis
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Gene expression and cancer classification
- Spinal Fractures and Fixation Techniques
- Trauma and Emergency Care Studies
- Ubiquitin and proteasome pathways
- Neurological Complications and Syndromes
- Brain Metastases and Treatment
- Research in Social Sciences
Tampere University Hospital
2019-2025
Tampere University
2019-2025
The aim of this study was to determine the population-based epidemiology chronic subdural hematoma (CSDH) over a 26-year period.
Abstract Objective To examine the population-based incidence, complications, and total, direct hospital costs of chronic subdural hematoma (CSDH) treatment in a neurosurgical clinic during 26-year period. The aim was also to estimate necessity planned postoperative follow-up computed tomography (CT). Methods A retrospective cohort (1990–2015) adult patients living Pirkanmaa, Finland, with CSDH identified using ICD codes verified by medical records ( n = 1148, median age 76 years, men 65%)....
Abstract Objective To assess possible long-term excess mortality and causes of death patients with chronic subdural hematoma (CSDH). Methods A retrospective study (1990–2015) adult ( n = 1133, median age 76 years old, men 65%) CSDH identified by ICD-codes verified medical records. All were followed until or the end 2017. Cumulative relative survival ratios risks (RER) estimated comparing patients’ that in entire regional matched population. The compared a separate reference group formed...
Abstract The tumor immune microenvironment (TiME) of human central nervous system (CNS) tumors remains to be comprehensively deciphered. Here, we employed flow cytometry and RNA sequencing analysis for a deep data-driven dissection diverse TiME uncover noncanonical cell types in CNS by using seven from five patients. Myeloid subsets comprised classical microglia, monocyte-derived macrophages, neutrophils, two myeloid subsets: CD3 + myeloids CD19 myeloids. T lymphocyte included...
A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk postoperative thromboembolic and hemorrhagic complications in CSDH with a history AF their association outcome. This posthoc analysis nationwide multicenter randomized controlled trial conducted during 2020-2022 included preoperative AF. incidence associations functional outcomes mortality. Of 589 patients, 128...
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding this process is paramount importance for improved care. In project, we analyzed matched IDH-mutant before and after to from six patients (discovery cohort) with genome-wide sequencing, 21 additional targeted 33 Glioma Longitudinal AnalySiS cohort validation. The Cancer Genome Atlas data 595 gliomas provided supportive information. All in our discovery...
Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain known for their aggressiveness and aberrant but still unresolved epigenetic regulation. To better understand malignancy, we investigated how AT/RT-specific DNA hypermethylation was associated with gene expression altered transcription factor binding it is linked to upstream Medulloblastomas, choroid plexus tumors, pluripotent stem cells, fetal were used as references. A part of the genomic regions, which hypermethylated in AT/RTs...
The objective was to determine the incidence of surgically treated chronic subdural hematoma (cSDH) within six months after head trauma in a consecutive series injury patients with normal initial computed tomography (CT). A total 1941 adult injuries who underwent CT 48 h and were at Tampere University Hospital's emergency department retrospectively evaluated from medical records (median age = 59 years, IQR 39-79 males 58%, using antithrombotic medication 26%). Patients no signs acute...
Abstract Oligodendrogliomas are typically associated with the most favorable prognosis among diffuse gliomas. However, many of tumors progress, eventually leading to patient death. To characterize changes oligodendroglioma recurrence and progression, we analyzed two recurrent upon diagnosis after tumor relapse based on whole-genome RNA sequencing. Relapsed were diagnosed as glioblastomas an component before World Health Organization classification update in 2016. Both patients died within 12...
Background and objectives The of this study were to investigate the prognostic value primary symptoms leading in adult patients with diffuse infiltrating glioma provide a clinical perspective for evaluating survival. Methods This included retrospective cohort from two tertiary university hospitals ( n = 604, 2006–2013, Tampere University Hospital Turku Hospital) prospective 156, 2014–2018, Hospital). Preoperative divided into symptoms. Results validated newer WHO 2021 classification...
Abstract Background Post-traumatic hydrocephalus (PTH) is a well-known complication of head injury. The percentage patients experiencing PTH in trauma cohorts (0.7–51.4%) varies greatly the prior literature depending on study population and applied diagnostic criteria. objective was to determine incidence surgically treated consecutive series undergoing acute computed tomography (CT) following Methods All ( N = 2908) with injuries who underwent CT were at Tampere University Hospital’s...
The purpose of our study was to analyze the impact time interval from referral surgery and adjuvant treatment on survival adult IDH-wildtype glioblastomas. Data 392 glioblastomas diagnosed at Tampere University Hospital in 2004–2016 were obtained electronic patient record system. Piecewise Cox regression used calculate hazard ratios for different intervals between surgery, as well treatments. median primary 9.5 months (interquartile range: 3.8–16.0). Survival among patients with an exceeding...
25 Background: The brain tumor immune microenvironment (TiME) is characterised by suppression of tumor-infiltrating leukocytes. lymphocyte niche activity particularly downregulated within this TiME milieu. Methods: Here, using data-driven approaches in flow cytometry and RNA sequencing analysis, we aimed at dissecting leukocyte cell types infiltrating human TiME. Results: Unsupervised clustering provided T subsets including double-negative (CD3 + CD4 - CD8 ) cells (DNT). Our DNT phenotype...
Abstract BACKGROUND The progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, therefore a better understanding this process is paramount importance for improved care. MATERIAL AND METHODS We analyzed next-generation sequencing data from matched IDH-mutant before and after to up 27 patients as well publicly available Cancer Genome Atlas (TCGA) 595 cases. All in our discovery cohort with genome-wide received radiation, all but one underwent...
Abstract Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain known for their aggressiveness, exceptionally low mutation rate, and aberrant but still unresolved epigenetic regulation. To evaluate methylation associated regulation in AT/RTs, we compared them to medulloblastomas choroid plexus by integrating DNA (507 samples), gene expression (120 public transcription factor (TF) binding data. We showed that elevated masks the sites of TFs driving neural development is with reduced...
Abstract IDH-mutant low-grade diffuse astrocytomas frequently progress to grade IV with implications for patient prognosis. To better understand this process, we applied whole-genome and transcriptome sequencing matched tumor samples collected before after progression from five patients. All tumors carried an IDH1 mutation. The number of chromosomal rearrangements was increased between 1.3 3.5-fold in the upon progression, exception one case, which increase only 1.03-fold. This case...
Abstract Understanding oncogenic epigenetic mechanisms in brain tumors is crucial for improved diagnosis and treatment. Recently DNA methylation has proven to be powerful tumor characterization diagnostic classification. To evaluate type specific features, we compared atypical teratoid/rhabdoid (AT/RTs), medulloblastomas (MBs), choroid plexus with each other by integrating (507 samples), gene expression (120 transcription factor (TF) -binding data. Different entities were used find unique...