A5063957601- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
Cancer Research Center
2024
Tampere University
2021-2024
Tampere University Hospital
2024
Prostate Cancer Research
2024
Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain known for their aggressiveness and aberrant but still unresolved epigenetic regulation. To better understand malignancy, we investigated how AT/RT-specific DNA hypermethylation was associated with gene expression altered transcription factor binding it is linked to upstream Medulloblastomas, choroid plexus tumors, pluripotent stem cells, fetal were used as references. A part of the genomic regions, which hypermethylated in AT/RTs...
Abstract Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain known for their aggressiveness, exceptionally low mutation rate, and aberrant but still unresolved epigenetic regulation. To evaluate methylation associated regulation in AT/RTs, we compared them to medulloblastomas choroid plexus by integrating DNA (507 samples), gene expression (120 public transcription factor (TF) binding data. We showed that elevated masks the sites of TFs driving neural development is with reduced...