A5038026731- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
LMU Klinikum
2024
Ludwig-Maximilians-Universität München
2023-2024
Innovative, efficient treatments are desperately needed for people with glioblastoma (GBM).
Background: The treatment of glioblastomas, the most common primary malignant brain tumors, with a devastating survival perspective, remains major challenge in medicine. Among recently explored therapeutic approaches, 5-aminolevulinic acid (5-ALA)-mediated interstitial photodynamic therapy (iPDT) has shown promising results. Methods: A total 16 patients suffering from de novo glioblastomas and undergoing iPDT as their were retrospectively analyzed regarding characteristic tissue regions...
5-aminolevulinic acid (5-ALA) mediated interstitial photodynamic therapy (iPDT) is undergoing clinical trials for the treatment of malignant gliomas. 5-ALA iPDT based on creation reactive oxygen species (ROS) via excitation protoporphyrin IX (PpIX) in tumor cells and causing a phototoxic reaction. After local chemo-radiation performed as adjuvant therapy. 16 newly diagnosed glioblastomas 44 glioma recurrences treated with Munich were retrospectively analyzed outcome, spectral online...
Different clinical aspects of photodynamic therapy (PDT), like treatment planning, and dosimetry protocols, spectral on-line-monitoring (SOM) as well follow-up evaluation outcome, are interest regarding further iPDT developments. For three specific applications, interstitial PDT (iPDT) for prostate cancer in urology, intraluminal cholangiocarcinoma gastroenterology stereotactic glioblastoma neurosurgery, the scenario is described. If all information arising around a intervention combined,...
As the most common primary malignant brain tumor with a devastating survival perspective, glioblastoma treatment remains major challenge in medicine. Among recent approaches, 5-aminolevulnic acid (5-ALA) mediated interstitial photodynamic therapy (iPDT) has shown promising results. 16 patients de-novo treated iPDT were retrospectively analyzed regarding and characteristic tissue regions discernible recorded MRI data. These segmented at different stages analyzed, especially their impact on...
Stereotactic interstitial photodynamic therapy using 5 aminolevulinic acid is a more upcoming approach for the treatment of malignant gliomas, whose remaining major challenge in brain tumor therapy. The therapeutic outcome 16 patients who underwent 5-ALA iPDT newly diagnosed glioblastomas, are presented. In addition to basic survival analysis, MRI data was analyzed concerning image changes after and possibility use these as prognostic factor response. Overall showed progression-free (PFS)...
Abstract Background Metastatic prostate cancer remains a therapeutic challenge. Based on data of the STAMPEDE trial, patients with low metastatic burden showed prolonged failure-free and overall survival when treated radio therapy (RT) in addition to standard care (SOC). The objective this study was determine cost-effectiveness additional RT compared SOC alone for following subgroups: non-regional lymph node (NRLN) metastases, up three bone metastases four or more metastases. Methods A...