A5079468241- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Bladder and Urothelial Cancer Treatments
- Photoacoustic and Ultrasonic Imaging
- Porphyrin and Phthalocyanine Chemistry
- Glioma Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Porphyrin Metabolism and Disorders
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- Cervical Cancer and HPV Research
- Laser Applications in Dentistry and Medicine
- Reconstructive Surgery and Microvascular Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Iron Metabolism and Disorders
- Oral Health Pathology and Treatment
- Reconstructive Facial Surgery Techniques
- Infrared Thermography in Medicine
- Advanced Fluorescence Microscopy Techniques
- Dermatologic Treatments and Research
- Spectroscopy Techniques in Biomedical and Chemical Research
Ludwig-Maximilians-Universität München
2015-2024
LMU Klinikum
2015-2024
Laser- und Medizin-Technologie (Germany)
2013-2021
München Klinik
1996-2019
Albert Schweitzer Klinik
2016
Klinik für Schlafmedizin
2016
University Hospital Münster
2016
University College London
2009-2011
University College Hospital
2009-2011
LungenClinic Grosshansdorf
2001-2010
No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996Detection Early Bladder Cancer by 5-Aminolevulinic Acid Induced Porphyrin Fluorescence Martin Kriegmair, Reinhold Baumgartner, Ruth Knuchel, Herbert Stepp, Ferdinand Hofstadter, and Alfons Hofstetter KriegmairMartin Kriegmair More articles this author , BaumgartnerReinhold Baumgartner KnuchelRuth Knuchel SteppHerbert Stepp HofstadterFerdinand Hofstadter HofstetterAlfons View All Author...
BACKGROUND: 5-Aminolevulinic acid is used for fluorescence-guided resections. During resection, different macroscopic fluorescence qualities (“strong,” “weak”) can be distinguished that help guide OBJECTIVE: This prospective study was designed to assess the reliability of visible by spectrometry, pathology, and imaging. METHODS: Thirty-three patients with malignant gliomas received 5-aminolevulinic (20 mg/kg). After debulking surgery, standardized biopsies were obtained from tissues “weak”...
Abstract Background and Objective Limited knowledge of the light temperature distribution within target volume in combination with non‐selective accumulation applied photosensitizers (PS) has hampered clinical relevance interstitial photodynamic therapy (iPDT) for treatment malignant glioma patients. The current pilot study focused on development implementation an accurate reproducible irradiation scheme iPDT using 5‐aminolevulinic acid (5‐ALA) induced protoporphyrin IX (PPIX) as a...
Background: Oral application of 20 mg/kg body weight 5-aminolevulinic acid (ALA) leads to a highly specific accumulation fluorescent Protoporphyrin IX (PPIX) in malignant glioma tissue. In the past few years, we have participated several clinical studies designed investigate fluorescence guided resection (FGR) and photodynamic therapy (PDT). Methods: PPIX selectivity bleaching during PDT were assessed with spectroscopic measurements. FGR was performed 18 clinics Germany (ALA-Glioma Study...
Abstract Background and Objective Interstitial photodynamic therapy (iPDT) of non‐resectable recurrent glioblastoma using 5‐aminolevulinic acid (ALA)‐induced protoporphyrin IX (PpIX) has shown a promising outcome. It remained unclear, however, to what extent inter‐ intra‐tumoural differences PpIX concentrations influence the efficacy iPDT. In current pilot study, we analysed quantitatively assessed induced fluorescence photobleaching intraoperatively. Materials Methods Five patients...
Five-aminolevulinic acid (5-ALA) is used for fluorescence-guided resections of malignant glioma at a dose 20 mg/kg; yet, it unknown whether lower doses may also provide efficacy.
Background and Objective An early detection of oral cancer might improve the patient's prognosis. We present preliminary results autofluorescence photodetection cancerous mucosa. Materials Methods 49 patients were investigated altogether. In 30 patients, malignant healthy mucosa excited with violet light (λ = 375 to 440 nm). Images recorded by a sensitive CCD camera. Spectrophotometric analysis in green spectral range was performed on tumorous innocuous 36 patients. Results 13 (43.3%),...
Abstract Fluorescence diagnosis aims to improve the management of oral cancer via early detection malignant lesions and better delimitation tumor margins. This paper presents a comparative study normal inspection, combined fluorescence (CFD) its 2 main components, autofluorescence 5‐aminolevulinic acid (5‐ALA)‐induced protoporphyrin IX (PPIX) fluorescence. Biopsy‐controlled imaging spectral analysis were performed on total 85 patients with suspected or histologically proven carcinoma both...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2001CLINICAL EXPERIENCE WITH 5-AMINOLEVULINIC ACID AND PHOTODYNAMIC THERAPY FOR REFRACTORY SUPERFICIAL BLADDER CANCER RAPHAELA WAIDELICH, HERBERT STEPP, REINHOLD BAUMGARTNER, ERNST WENINGER, ALFONS HOFSTETTER, and MARTIN KRIEGMAIR WAIDELICHRAPHAELA WAIDELICH , STEPPHERBERT STEPP BAUMGARTNERREINHOLD BAUMGARTNER WENINGERERNST WENINGER HOFSTETTERALFONS HOFSTETTER KRIEGMAIRMARTIN View All Author...
Abstract Protoporphyrin IX (PpIX) produced from exogenous, orally administered 5‐aminolevulinic acid (ALA) displays high tumor‐selective uptake and is being successfully employed for fluorescence‐guided resection (FGR) of human malignant gliomas. Furthermore, the phototoxicity PpIX can be utilized photodynamic therapy (PDT) brain tumors, which has been shown previously. Here, absolute concentration in tissue was investigated following oral ALA administration (20 mg kg −1 b.w.). An extraction...
Objective To identify and save parathyroid glands during thyroidectomy by displaying their autofluorescence. Methods Autofluorescence imaging was carried out with without central lymph node dissection. After visual recognition the surgeon, surrounding tissue were exposed to near-infrared light a wavelength of 690-770 nm using modified Karl Storz near infrared/indocyanine green endoscopic system. Parathyroid expected show infrared autofluorescence at 820 nm, captured in blue channel camera....
Interstitial photodynamic therapy (iPDT) using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) as a cytotoxic photosensitizer could be feasible treatment option for malignant gliomas. In monocentric cohort of consecutive patients treated between 2006 and 2018, risk profile analysis salvage iPDT local glioma recurrences associated outcome measures are presented here. It was considered indicated in with circumscribed biopsy-proven after standard therapy, if not deemed eligible...
Innovative, efficient treatments are desperately needed for people with glioblastoma (GBM).