A5005969481- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Pharmacological Effects and Toxicity Studies
- Radiomics and Machine Learning in Medical Imaging
- Palliative Care and End-of-Life Issues
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Autoimmune Neurological Disorders and Treatments
- Cancer Treatment and Pharmacology
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Epilepsy research and treatment
- Cancer-related cognitive impairment studies
- Immunotherapy and Immune Responses
- Management of metastatic bone disease
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Neurological Complications and Syndromes
- Cerebrovascular and Carotid Artery Diseases
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
- Atrial Fibrillation Management and Outcomes
- Myasthenia Gravis and Thymoma
Karl Landsteiner University of Health Sciences
2017-2025
Universitätsklinikum St. Pölten
2014-2024
University Hospital of Bern
2024
University of Bern
2024
Karl Landsteiner Society
2015-2023
St. Pölten University of Applied Sciences
2013-2022
VASCage
2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
University of Pennsylvania
2018
Medical University of Graz
2013-2016
Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral as prognostic factor controversial.This multi-centre clinical retrospective study included 110 with histologically proven glioblastoma. impact on overall survival pre-treatment detected MRI-scans was evaluated. All had preoperative MRI, surgery, histology, received standard treatment regimens. Edema classified minor (<1...
Dendritic cells (DCs) are antigen-presenting that capable of priming anti-tumor immune responses, thus serving as attractive tools to generate tumor vaccines. In this multicentric randomized open-label phase II study, we investigated the efficacy vaccination with lysate-charged autologous DCs (Audencel) in newly diagnosed glioblastoma multiforme (GBM). Patients aged 18 70 years histologically proven primary GBM and resection at least 70% were 1:1 standard care (SOC) or SOC plus (weekly...
Abstract Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in cerebrospinal fluid and presents as majority patients. Only few neuropathological reports are available little known about pathogenic mechanisms. We performed histopathological study two autopsies nine CNS biopsies patients with found predominantly lymphocytic one...
Due to the redundancy of molecular pathways simultaneously involved in glioblastoma growth and angiogenesis, therapeutic approaches intervening at multiple levels seem particularly appealing. This prospective, multicenter, single-arm phase II trial was designed evaluate antitumor activity sunitinib, an oral small-molecule inhibitor several receptor tyrosine kinases, patients with first recurrence primary using a continuous once-daily dosing regimen. Patients received starting dose sunitinib...
Purpose To explore the diagnostic performance of physiological magnetic resonance (MR) imaging oxygen metabolism and neovascularization activity for grading characterization isocitrate dehydrogenase (IDH) gene mutation status gliomas. Materials Methods This retrospective study had institutional review board approval; written informed consent was obtained from all patients. Eighty-three patients with histopathologically proven glioma (World Health Organization [WHO] grade II–IV) were examined...
The precise initial characterization of contrast-enhancing brain tumors has significant consequences for clinical outcomes. Various novel neuroimaging methods have been developed to increase the specificity conventional magnetic resonance imaging (cMRI) but also increased complexity data analysis. Artificial intelligence offers new options manage this challenge in settings. Here, we investigated whether multiclass machine learning (ML) algorithms applied a high-dimensional panel radiomic...
Despite aggressive treatment, outcome of patients with glioblastoma is poor. Several distinct clinical problems arise in the terminal stage this disease. The purpose study was to evaluate end-of-life phase a hospital setting glioblastoma. Twenty-nine consecutive glioblastoma, who died our department, were included analysis regarding symptoms, medication, diagnostics, and interventional procedures. comparable respect age, gender, overall survival data from literature. Relevant medications,...
Background and Purpose— Cognitive impairment occurs in ≤30% of all stroke survivors. However, effective therapies aimed at preventing poststroke cognitive decline are lacking. We assessed the efficacy a multidomain intervention on after stroke. Methods— In this randomized, observer-blind trial patients were recruited within 3 months an acute 5 Austrian neurological centers. Patients assigned to 24-month lifestyle-based or standard care. Primary outcomes subscale Alzheimer Disease Assessment...
Abstract Background The intratumoral heterogeneity of oxygen metabolism in combination with variable patterns neovascularization (NV) as well reprogramming energy affects the landscape tumor microenvironments (TMEs) glioblastoma. Knowledge hypoxic and perivascular niches within TME is essential for understanding treatment failure. Methods Fifty-two patients untreated glioblastoma (isocitrate dehydrogenase 1 wild type [IDH1wt]) were examined a physiological MRI protocol including...
Abstract Background Novel approaches to guide personalized treatment in glioblastoma are urgently needed. Given the poor predictive value of genetic biomarkers glioblastoma, we conducting a prospective clinical trial investigate novel approach cultivated patient-derived tumor cells (PDCs) for ex vivo drug screening. Methods In this randomized phase 2 study, testing ability PDC-based screening formulate recommendation maintenance patients with newly diagnosed unmethylated MGMT promoter after...
Familial hemiplegic migraine (FHM) is a rare inherited autosomal dominant disorder. Migraine aura may last up to several weeks and then resolve without sequel. We report 21-year-old male with FHM since the age of 3 years. Diffusion-weighted magnetic resonance imaging (DWI), perfusion-MR (P-MRI) [99mTc] hexamethyl-propyleneamine-oxime-single photon emission tomography (HMPAO-SPECT) were performed on day 2, when he was somnolent right-sided hemiplegia, 9 mild hemiparesis still present 24 after...
Paraneoplastic neurological syndromes (PNSs) cover a wide range of diseases and involve both the central nervous system (CNS) peripheral system. encephalitis comprises several such as paraneoplastic cerebellar degeneration (PCD), limbic (LE), encephalomyelitis (PEM), brainstem encephalitis, opsomyoclonus syndrome, in addition to other even less frequently occurring entities. LE was first historically identified CNS PNS, similarities between temporal lobe herpes have been elucidated. In past...
High-grade gliomas are the most frequent primary brain tumors. Despite improvement in diagnostics and treatment, survival is still poor quality-of-life issues of major importance. Little known regarding clinical signs symptoms dying patients with glioblastoma.The aim this study was to investigate as well therapeutic strategies glioblastoma end-of-life phase order improve care.In prospective single-center study, data were obtained using a standardized protocol. We descriptively analyzed...
Knowledge about the topological and structural heterogeneity of microvasculature is important for diagnosis monitoring glioma. A vessel caliber type-dependent temporal shift in magnetic resonance imaging signal forms basis vascular architecture mapping. This study introduced a clinically feasible approach assessment pathologies gliomas using Sixty consecutive patients with known or suspected were examined mapping as part routine protocol. Maps microvessel radius density, which adapted to...
Abstract Introduction Pilocytic astrocytoma (PA) is the most common primary brain neoplasm in children and treated curative intent with gross total resection (GTR). However, PA rare adults, resulting limited knowledge on natural clinical course. This study aimed to describe course identify prognostic factors of adult patients PA. Methods 46 ≥ 18 years at diagnosis neurosurgical or biopsy between 2000 2018 were identified from Neuro-Biobank Medical University Vienna. In two cases differing...