A5017593170- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Glioma Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Zebrafish Biomedical Research Applications
- Stellar, planetary, and galactic studies
- Radiomics and Machine Learning in Medical Imaging
- Astronomy and Astrophysical Research
- Optical Imaging and Spectroscopy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Cell Image Analysis Techniques
- Ocular and Laser Science Research
- Angiogenesis and VEGF in Cancer
- Astronomical Observations and Instrumentation
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Artery Disease Management
Medical University of Vienna
2016-2025
Innsbruck Medical University
2025
Universität Innsbruck
2025
Horiba (France)
2022
University of Vienna
1994-2021
Universität Ulm
2017-2019
Massachusetts Institute of Technology
2010-2017
Heilbronn University
2017
Tufts University
2011-2013
Centre for Biomedical Engineering and Physics
2007-2011
Ultrahigh speed 1050nm
Optic nerve head (ONH) blood flow may be associated with glaucoma development.A reliable method to quantify ONH could provide insight into the vascular component of pathophysiology.Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called splitspectrum amplitude-decorrelation (SSADA) for imaging microcirculation.In this study, SSADA results was and used detect perfusion changes in early glaucoma.En face maximum projection obtain 2D disc...
High speed Optical Coherence Tomography (OCT) has made it possible to rapidly capture densely sampled 3D volume data. One key application is the acquisition of high quality in vivo volumetric data sets human retina. Since acquired a few seconds, eye movement during scan process leads distortion, which limits accuracy quantitative measurements using OCT In this paper, we present novel software based method correct motion artifacts raster scans. Motion compensation performed retrospectively...
We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of human retina.Contrary to previous, intensity based segmentation algorithms, our uses an intrinsic tissue property RPE: its depolarizing, or scrambling effect on backscattered light.Two different algorithms are presented discussed: simpler algorithm retardation data, more sophisticated local variations state calculated from...
To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions patients with multiple sclerosis (MS).Fifty-two MS eyes 21 healthy control (HC) were included. There two subgroups: 38 without an neuritis (ON) history (MS -ON), 14 ON +ON). The OCT images captured by high-speed 1050 nm OCT. ONH flow index (FI) FI quantified from angiograms.The mean was 0.160 ± 0.010 for HC group, 0.156 0.017 MS-ON 0.140 0.020 MS+ON group. of group...
Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain for visualization and quantitative assessment of retinal blood flow. Using laser technology, the system operated 1050-nm wavelength range at a high axial scan rate 200 kHz. The rapid imaging not only enables volumetric with densities, but also measurement velocities central vessels. Deep penetration optic nerve lamina cribrosa was achieved...
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT. In addition to imaging based on tissue reflectivity, PS-OCT also enables depth-resolved mapping sample polarization properties such as phase-retardation, birefringent axis orientation, Stokes vectors, and degree uniformity (DOPU). this study, was used investigate the melanin. In-vitro measurements in samples with varying melanin concentrations revealed scrambling, i.e. depolarization backscattered...
<h3>Aims</h3> To quantify the change in drusen volume over time and identify its prognostic value for individual risk assessment. <h3>Methods</h3> A prospective observational study a minimum of 3 years maximum 5 follow-up examination every months was conducted at ophthalmology department Medical University Vienna. 109 patients presenting early intermediate age-related macular degeneration (AMD) were included, which 30 concluded regular least years. 50 eyes imaged using spectral-domain...
Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of sample.This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm 100kHz axial scan rates single mode fiber optics and multiplexing approach.Unlike previously reported schemes, uses passive polarization delay unit does not require active modulating devices.This advance...
Despite the challenges in achieving high phase stability, Doppler swept-source/Fourier-domain optical coherence tomography (OCT) has advantages of less fringe washout and faster imaging speeds compared to spectral/Fourier-domain detection. This Letter demonstrates swept-source OCT with a vertical cavity surface-emitting laser light source at 400 kHz sweep rate for phase-sensitive imaging, measuring pulsatile total retinal blood flow sensitivity stability. A robust, simple, computationally...
We demonstrate a new full range complex spectral domain optical coherence tomography (FRC SD-OCT) method. Other than FRC SD-OCT systems reported in literature, which employed devices such as electro-/acousto optic modulators or piezo-driven mirrors providing the phase modulations necessary for retrieval of complex-valued signal, system presented works without any additional shifting device. The required shift is introduced by galvanometer scanner used transversally scanning sample beam. By...
Purpose. Spectral-domain optical coherence tomography (SD-OCT) provides new insights into the understanding of age-related macular degeneration (AMD) but limited information on nature hyperreflective tissue at level retinal pigment epithelium. Therefore, polarization-sensitive (PS) SD-OCT was used to identify and characterize typical RPE findings in AMD. Methods. Forty-four eyes 44 patients with AMD were included this prospective case series representing entire spectrum from drusen (n = 11),...
We present polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of retinal pathologies in age-related macular degeneration (AMD). On the basis polarization scrambling characteristics pigment epithelium, novel segmentation algorithms were developed that allow one to segment pathologic features such as drusen and atrophic zones dry AMD well determine their dimensions. Results from measurements eyes patients prove ability PS-OCT imaging based on polarizing...
We present a new ultra high resolution spectral domain polarization sensitive optical coherence tomography (PS-OCT) system based on maintaining (PM) fibers. The method transfers the principles of our previous bulk optic PS-OCT systems to fiberized setup. phase shift between orthogonal states travelling in two modes PM fiber is compensated by software post processing. Thereby, main advantage optics setups, i.e. use only single input state simultaneously acquire reflectivity, retardation, axis...
We present a new instrument that is capable of imaging human photoreceptors in three dimensions. To achieve high lateral resolution, the system incorporates an adaptive optics system. The axial resolution achieved through implementation optical coherence tomography (OCT). records simultaneously both, scanning laser ophthalmoscope (SLO) and OCT en-face images, with pixel to correspondence. information provided by SLO used correct for transverse eye motion post-processing. In order motion,...
PurposeTo monitor retinal pigment epithelial (RPE) atrophy progression during antiangiogenic therapy of neovascular age-related macular degeneration (AMD) over 2 years using polarization-sensitive optical coherence tomography (OCT).DesignProspective interventional case series.Methodssetting: Clinical practice. study population: Thirty patients (31 eyes) with treatment-naïve AMD. observation procedures: Standard intravitreal (0.5 mg ranibizumab) was administered monthly the first year and pro...
We present an approach to measure pulsatile total retinal arterial blood flow in humans and rats using ultrahigh speed Doppler OCT. The axial velocity is measured en face plane by raster scanning the calculated integrating over vessel area, without need angle. By measuring at central artery, scan area can be very small. Combined with speed, this enables high volume acquisition rates necessary for measurement modification OCT system optics. A spectral domain 840nm rate of 244kHz was used...
The purpose of this work is to investigate the benefits adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing contrast vessels and small capillaries. Especially capability technique visualize capillaries with a lateral extension that below transverse resolution system opens unique opportunities diagnosing retinal vascular diseases. However, there are some limitations such as shadowing projection...
We present measurements of total retinal blood flow in healthy volunteers using a three beam Doppler optical coherence tomography (D-OCT) technique.This technology has the advantage precise determination vector without use any a-priori information on vessel geometry.Circular D-OCT scans around optic disc were recorded and venous as well arterial was determined compared for each subject.The reproducibility method assessed 6 subjects by repeated measurements.Only small deviations 6% between...
A visible light spectral domain optical coherence microscopy system was developed. high axial resolution of 0.88 μm in tissue achieved using a broad spectrum (425 - 685 nm). Healthy human brain imaged to quantify the difference between white (WM) and grey matter (GM) intensity attenuation. The enables investigation amyloid-beta plaques various sizes animal models Alzheimer's disease (AD). By performing spectroscopic analysis OCM data, differences characteristics for WM, GM, neuritic were...
The high acquisition speed of state-of-the-art optical coherence tomography (OCT) enables massive signal-to-noise ratio (SNR) improvements by signal averaging.Here, we investigate the performance two commonly used approaches for OCT averaging.We present theoretical SNR (a) computing average magnitude data and (b) averaging complex phasors, substantiate our findings with simulations experimentally acquired data.We show that achieved strongly depends on both input signals number averaged when...
Currently, approximately 150 different brain tumour types are defined by the WHO. Recent endeavours to exploit machine learning and deep methods for supporting more precise diagnostics based on histological appearance have been hampered relative paucity of accessible digital histopathological datasets. While freely available datasets relatively common in many medical specialties such as radiology genomic medicine, there is still an unmet need regarding data. Thus, we digitized a significant...