After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness dynamic O-(2-18F-Fluoroethyl)-L-Tyrosine positron emission tomography (18F-FET PET) in patients with MRI-based suspicion after metastases.Twenty-two 34 metastases (median age 61.9 years) were included. Due to follow-up scan evaluations repeated treatment a subset patients, total 50 could be...

The significance of surgical margins after resection soft tissue sarcomas in respect to local-recurrence-free survival and overall is evaluated.A total 305 patients with deep-seated, G2/3 (STS) the extremity, trunk wall, or pelvis were reviewed. margin was defined according Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) classification system (R0-2), Union Internationale (UICC) (R + 1 mm) for which a <1 mm included into R1 group, groups mm, 1-5 >5 >10 mm.Of these...

In the present study factors affecting survival and toxicity in cerebral metastasized patients treated with stereotactic radiosurgery (SRS) were analyzed special focus on radiation necrosis. 340 1–3 metastases having been SRS retrospectively analyzed. Radiation necrosis was diagnosed by MRI und PET imaging. Univariate multivariate analysis using a Cox proportional hazards regression model log-rank test performed to determine prognostic value of treatment-related individual for outcome...

There is limited data on the use of targeted or immunotherapy (TT/IT) in combination with single fraction stereotactic radiosurgery (SRS) patients melanoma brain metastasis (MBM). Therefore, we analyzed outcome and toxicity SRS alone compared to TT/IT.Patients MBM treated session at our department between 2014 2017 a minimum follow-up 3 months after first were included. The primary endpoint this study was local control (LC). Secondary endpoints distant intracranial control, radiation...

Abstract Background Soft tissue sarcomas (STSs) are a heterogeneous group of tumors. Wide surgical resection is standard, often combined with neoadjuvant chemotherapy, radiotherapy, or both. Studies have shown the predictive value tumor necrosis in bone sarcoma (BS); however, role STS after therapies still unclear. This study aimed to investigate chemo- and radiotherapy formation evaluate influence on overall survival local recurrence-free survival. Data from BS patients who did not receive...

Background: In soft tissue sarcomas, unplanned resections, or so-called Whoops procedures, do occur quite frequently, thus primarily owing to the abundant presence of benign lesions. Whether re-resection reduces local recurrence improves overall survival remains a topic ongoing debate. The principle objective this study was analyze outcomes patients with sarcomas extremities trunk wall after an incidental marginal resection by comparing re-resections individuals who declined procedure....

To report our results with postoperative or definitive radiation therapy in head and neck sarcomas. We performed a retrospective analysis of 26 patients suffering from sarcomas, who received between 2003 2012. Median age was 64 years (19–88) 69 % were male. Tumor locations skull (including skin) 31 %, paranasal sinus/orbita 27 pharynx/larynx) 42 %. tumor size 4.6 cm (1-12 cm). 22 (85 %) presented primary situation. Stage at presentation (UICC 7th for soft tissue sarcomas) as follows: Ia:4...

Sarcomas are rare, malignant tumors of soft tissues or bone. Limb salvage surgery (LSS) is the standard treatment, but amputation still an option, especially in local recurrence complications after LSS.We retrospectively reviewed indications and oncological outcomes patients who underwent amputation. Two groups with either primary amputations (n = 120) secondary failed LSS 29) were compared main end points LRFS OS.Five-year was 84% 17 (16%) developing recurrence, which 16 (13%) occurred...

Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data available allowing precise selection of suitable re-treatment in regard to safety and efficacy. Using the department database, 58 two courses percutaneous radiation were identified. Besides classical dose-volume histogram (DVH) parameters equivalent uniform dose (EUD) values calculated tumor organs at risk (OARs),...

Abstract To analyze efficacy, functional outcome, and treatment toxicity of low‐dose rate I‐125 brachytherapy (SBT) alone or in combination with best safe resection (in case larger tumor volumes) as first‐line for pediatric low‐grade gliomas (PLGGs) not suitable complete resection. Consecutively treated (2000–2014) complex located circumscribed WHO grade I/II PLGGs were included. For small tumors (≤4 cm diameter) SBT was performed; subsequent chosen. Temporary Iodine‐125 seeds used (median...

Radiation delivery for malignant brain tumors is gradually becoming more precise. Particularly the possibilities of sparing adjacent normal structures such as hippocampus are increasing. To determine its radiation exposure exactly, equivalent uniform dose (EUD) was compared with further treatment parameters. This way options could be found.From database University hospital Munich 61 glioblastoma patients were selected who received primary radiotherapy in 2011. General data about etiology,...

Abstract Background This long-term retrospective analysis aimed to investigate the outcome and toxicity profile of stereotactic brachytherapy (SBT) in selected low-grade gliomas WHO grade II (LGGII) a large patient series. Methods comprised 106 consecutive patients who received SBT with temporary Iodine-125 seeds for histologically verified LGGII at University Munich between March 1997 July 2011. Investigation included clinical characteristics, technical aspects SBT, application other...

Abstract Purpose Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) additional salvage external beam radiotherapy (EBRT) after tumor recurrence or vice versa remains unknown. Methods Patients treated low-activity temporary iodine-125 SBT at the University Munich between 1999 2016 who had EBRT were included. Biologically effective doses (BED) calculated. RN was diagnosed using biopsy and/or metabolic...

In soft tissue or bone sarcomas, multimodal therapeutic concepts represent the standard of care. Some patients reject recommendations due to several reasons. The aim this study was assess impact that rejection on both prognosis and local recurrence. Between 2012 2019, a total 828 sarcoma were surgically treated. Chemotherapy scheduled as neoadjuvant, adjuvant multi-agent therapy performed following from an interdisciplinary tumor board. Radiotherapy, if deemed appropriate, administered...

Abstract Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation thymidine phosphorylase (TP) by IR reverses chemoresistance PDAC cells. The resistant variant human cell line AsPC-1 (FU-R) was used determine sensitizing effects IR....

Objective: After radiosurgery of brain metastases, the MRI-based differentiation between tumor recurrence and radiation-induced lesions is challenging. In this context, place [18F] Fluoroethyltyrosine positron emission tomography ([18F]-FET PET) poorly defined. current[for full text, please go to a.m. URL]