A5050387640- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Surgical site infection prevention
- Hernia repair and management
- Stoma care and complications
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Hip and Femur Fractures
- Peroxisome Proliferator-Activated Receptors
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Vascular Procedures and Complications
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Receptor Mechanisms and Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipose Tissue and Metabolism
- Surgical Sutures and Adhesives
- Management of metastatic bone disease
- TGF-β signaling in diseases
Charité - Universitätsmedizin Berlin
2005-2023
Freie Universität Berlin
2021-2023
Humboldt-Universität zu Berlin
2021-2023
Park-Klinik Weißensee
2023
The University of Texas MD Anderson Cancer Center
2018-2020
University of Pennsylvania
2005
Two active metabolites of the angiotensin type 1 (AT1) receptor blocker losartan have been described previously, EXP3174 and EXP3179. Whereas is main antihypertensive AT1 receptor-blocking metabolite, role EXP3179 widely unknown. Recently, a subgroup blockers has identified as ligands for peroxisome proliferator-activated gamma (PPAR-gamma). Here we characterize PPAR-gamma-activating properties 2 metabolites. PPAR-gamma activity was measured with chimeric Gal4-DNA-binding...
Colorectal cancer in the young adult population is of increasing incidence and concern. Genetic predisposition heritable syndromes contribute to this trend, but perhaps more concerning majority new diagnoses that involve no traceable genetic risk factors. Prevention early recognition, with a high suspicion symptomatic adult, are critical attenuating recent trends. Clinical management requires coordinated multidisciplinary care from diagnosis surveillance order ensure appropriate management....
Objective: To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline. Background: SSI is a common complication after gastrointestinal surgery. date, there lack of evidence beneficial terms reduction SSI. Methods: The RECIPE trial was an investigator initiated single-center, single-blind prospective, randomized controlled 2 parallel treatment groups, comparing 0.9% saline...
Telmisartan is an angiotensin I (AT1) receptor blocker used in the treatment of essential hypertension, with partial peroxisome proliferator-activated γ (PPARγ) agonism. In prior studies, PPARγ activation led to apoptosis and cell cycle inhibition various cancer cells. The aim present study was investigate potential antiproliferative apoptotic effects telmisartan by partially activating PPARγ. HT-29, SW-480 SW-620 cells were incubated (0.2-5 μM) or full agonist, pioglitazone (0.2-5.0 μM)....
Abstract Purpose Currently, the exact role of estrogen receptor (ER) signaling in pancreatic cancer is unknown. Recently, we showed that expression phosphorylated ERβ correlates with a poor prognosis patients ductal adenocarcinoma (PDAC). Here, hypothesized raloxifene, FDA-approved selective ER modulator (SERM), may suppress PDAC tumor growth by interfering signaling. To test this hypothesis, studied impact raloxifene on interleukin-6/glycoprotein-130/signal transducer and activator...
Abstract Purpose Surgical site infection (SSI) occurs in up to 25% of patients after elective laparotomy. We aimed determine the effect SSI on healthcare costs and patients’ quality life. Methods In this post hoc analysis based RECIPE trial, we studied a 30-day postoperative outcome single-center, prospective randomized controlled trial comparing subcutaneous wound irrigation with 0.04% polyhexanide 0.9% saline Total medical were analyzed accurately per patient tool our corporate controlling...
Abstract Background The safety of synthetic mesh in elective hernia repair the setting immunosuppression lacks national and international consensus. aim our analysis was to explore effects on rates wound complications. Methods Comparative immunocompetent immunocompromised patients with inguinal, femoral, primary ventral, incisional or parastomal between January 2001 December 2013. Immunosuppression included glucocorticoids, biologicals, chemotherapy chemoradiotherapy. Primary outcome...
Abstract Purpose Colorectal cancer revealed over the last decades a remarkable shift with an increasing proportion of right- compared to left-sided tumor location. In current study, we aimed disclose clinicopathological differences between and colon (rCC lCC) respect mortality outcome predictors. Methods total, 417 patients stage I–IV were analyzed in present retrospective single-center study. Survival rates assessed using Kaplan–Meier method uni/multivariate analyses performed Cox...
Background: Surgical site infections (SSIs) are a common complication in visceral surgery. Pathogens causing SSIs vary depending on the type of Patients and Methods: Within scope Reduction Postoperative Wound Infections by Antiseptica (RECIPE) trial we analyzed pathogens cultured intra-operative, subcutaneous swabs from SSI single-center, prospective, randomized controlled study. Definition complied with criteria U.S. Centers for Disease Control Prevention (CDC). Results: The overall rate...
In patients on oral antiplatelet therapy secondary to critical vascular diseases, the risk of interrupting has be weighed against postoperative hematoma or bleeding when surgery is planned. The goal this study was determine and in elective inguinal hernia during continuous platelet inhibition. Patients receiving either total extraperitoneal hernioplasty Lichtenstein repair for were included. with mere suture repair, emergency combination different simultaneous operations, under therapeutic...
Abstract Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation thymidine phosphorylase (TP) by IR reverses chemoresistance PDAC cells. The resistant variant human cell line AsPC-1 (FU-R) was used determine sensitizing effects IR....
Background/Aim: Evidence of metastatic disease precludes oncological resection pancreatic cancer. Near-infrared (NIR) fluorescent labels, such as indocyanine green (ICG), assist in the intraoperative detection occult and micrometastatic liver disease. The present study aimed to analyse role NIR fluorescence imaging using ICG for proof concept an orthotopic athymic mouse model. Materials Methods: Pancreatic ductal adenocarcinoma was induced by injecting L3.6pl human tumour cells into tail...
Worldwide, at least a quarter of the patients with colorectal cancer (CRC) are diagnosed metastatic disease presentation and many them eventually succumb to their disease. A third these may have burden confined liver. It has been estimated that about 15–25% CRC initially present synchronous resectable liver metastases (SRLM) (1). These represent group whose oncologic prognosis significantly improved over past decades (2).