A5014318965- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Microscopic Colitis
- Stoma care and complications
- Autoimmune and Inflammatory Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Osteoarthritis Treatment and Mechanisms
- Surgical site infection prevention
- COVID-19 and healthcare impacts
- Colorectal and Anal Carcinomas
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Microbial Inactivation Methods
- Genetic factors in colorectal cancer
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
Charité - Universitätsmedizin Berlin
2011-2024
Humboldt-Universität zu Berlin
2021-2024
Freie Universität Berlin
2021-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022
Franklin University
2021
Ludwig-Maximilians-Universität München
2006-2009
Abstract : Resveratrol is a polyphenolic phytoalexin that present in various fruits, the skin of red grapes and peanuts. Recent studies have shown resveratrol exhibits potent antioxidant properties able to exert anti‐inflammatory anti‐catabolic several cell types. The pro‐inflammatory cytokine interleukin‐1β (IL‐1β) plays pivotal role pathogenesis osteoarthritis (OA) humans animals. In this article we investigated whether block effects IL‐1β, specifically activation caspase‐3 subsequent...
Background: The popularity of robotic-assisted surgery for rectal cancer is increasing, but its superiority over the laparoscopic approach regarding safety, efficacy, and costs has not been well established. Methods: A retrospective single-center study was conducted comparing consecutively performed surgeries between 1 January 2016 31 September 2021. In total, 125 adult patients with sporadic adenocarcinoma (distal extent ≤ 15 cm from anal verge) underwent where 66 were operated on...
Knowledge about the changes in electric conductivity during coagulation process of radiofrequency ablation liver is a prerequisite for predictability produceable thermonecrosis liver.Continuous measurements sigma ex vivo porcine (n = 25) were done and cooling at temperature range frequency 470 kHz relevant ablation. Measurements performed both perfused 3) human surgical specimen from colorectal metastasis.At body 37 degrees C, conductance was 0.41 siemens per metre (0.32 S/m; 0.52 S/m)....
Abstract Introduction The role of visceral fat in disease development, particularly Crohn´s (CD), is significant. However, its preoperative prognostic value for postoperative complications and CD relapse after ileocecal resection (ICR) remains unknown. This study aims to assess the predictive potential preoperatively measured subcutaneous recurrence using magnetic resonance imaging (MRI). primary endpoint was anastomotic leakage ileocolonic anastomosis, with secondary endpoints evaluating...
Pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) play a key role in the pathogenesis of Osteoarthritis (OA). The aim this study was to investigate potential anti-inflammatory properties growth factors IGF-I and/or TGF-beta1 on IL-1beta signalling pathways their effect chondrogenic dedifferentiated human articular chondrocytes vitro. Serum-starved were treated with induce dedifferentiation further at various concentrations. effects...
Objectives: The COVID-19 pandemic and its associated restrictions have resulted in delayed diagnoses across various tumor entities, including rectal cancer. Our hypothesis was based on the expectation of a reduced number primary operations due to higher stages compared control group. Methods: In single-center retrospective study conducted from 1 March 2018 2022, we analyzed 120 patients with an initial diagnosis Among them, 65 were part group (pre-COVID-19), while 55 included (during...
Abstract Purpose Surgical site infection (SSI) occurs in up to 25% of patients after elective laparotomy. We aimed determine the effect SSI on healthcare costs and patients’ quality life. Methods In this post hoc analysis based RECIPE trial, we studied a 30-day postoperative outcome single-center, prospective randomized controlled trial comparing subcutaneous wound irrigation with 0.04% polyhexanide 0.9% saline Total medical were analyzed accurately per patient tool our corporate controlling...
Background: Robotic-assisted colorectal surgery is gaining popularity, but limited data are available on the safety, efficacy, and cost of robotic-assisted restorative proctectomy with construction an ileal pouch pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). Methods: A retrospective study was conducted comparing consecutively performed laparoscopic IPAA between 1 January 2016 31 September 2021. In total, 67 adult patients medically refractory UC without proven dysplasia or...
Prolonged postoperative ileus (PPOI) is common after bowel resections, especially in Crohn's disease (CD). The pathophysiology of PPOI not fully understood. could affect only the upper or lower gastrointestinal (GI) tract. aim this study was to assess risk factors for diverse types PPOI, particularly differentiate and GI tract.A retrospective analysis 163 patients with CD undergoing ileocecal resection from 2015 2020 a single center performed. tract predefined as presence vomiting use...
Myopenia and myosteatosis have been proposed to be prognostic factors of surgical outcomes for various diseases, but their exact role in Crohn's disease (CD) is unknown. The aim this study evaluate impact on anastomotic leakage, CD recurrence, postoperative complications after ileocecal resection patients with CD.A retrospective analysis undergoing at our tertiary referral center was performed. To assess myopenia, skeletal muscle index (skeletal area normalized body height) measured using an...
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Background: For locally advanced rectal cancer, neoadjuvant therapy (NT) is an established element of therapy. Endoscopic vacuum (EVT) has been a relevant treatment option for anastomotic leakage after resection since 2008. The aim was to evaluate the influence NT on duration and success EVT in cancer. Methods: This monocentric, retrospective cohort study including patients who underwent with primary anastomosis because histologically proven carcinoma rectum Department General Visceral...
Inflammation of the rectal remnant may affect postoperative outcome ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We aimed to determine extent inflammation anastomotic area during IPAA and investigate impact proctitis on complications long-term outcomes.Three hundred thirty-four UC primary were included this retrospective case-control study. The histopathologic degree was graded into three stages no ("NOP"), mild medium ("MIP"), severe ("SEP"). Preoperative...
Abstract Background Surgical closure of anal fistulas with rectal advancement flaps is an established standard method, but it has a high degree healing failure in some cases. The aim this study was to identify risk factors for fistula after flap placement between patients cryptoglandular and Crohn’s disease (CD). Methods From January 2010 October 2020, 155 (CD = 55, non-CD 100) were performed. Patients entered into prospective database, rates retrospectively analysed. Results median...
Background: Ileostomy is often required in patients undergoing bowel resections for inflammatory diseases (IBD), colorectal cancer, and emergencies. Unfortunately, some develop a high-output stoma (HOS). This condition affects homeostasis may be life threatening. We aimed to identify possible risk factors the development of HOS. Patients methods: From 2012 2018, 296 who underwent ileostomy at Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin were retrospectively analyzed....
Patients with Crohn's disease suffer from a higher rate of anastomotic leakages after ileocecal resection than patients without disease. Our hypothesis was that microscopic inflammation at the margins resections in increases leakages.In retrospective cohort study, 130 underwent between 2015 and 2019, were analyzed. Anastomotic leakage primary outcome parameter. Inflammation margin characterized as "inflammation proximal margin", distal margin" or both ends".46 (35.4%) showed margins. 17...