A5010761964- Peripheral Artery Disease Management
- Colorectal Cancer Surgical Treatments
- Muscle and Compartmental Disorders
- Surgical site infection prevention
- Pancreatic and Hepatic Oncology Research
- Surgical Sutures and Adhesives
- COVID-19 and healthcare impacts
- Cerebrovascular and Carotid Artery Diseases
- Cancer Genomics and Diagnostics
- Microscopic Colitis
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Antimicrobial Resistance in Staphylococcus
- Medical Imaging and Pathology Studies
- Colorectal Cancer Screening and Detection
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Aortic Disease and Treatment Approaches
- Optical Imaging and Spectroscopy Techniques
- Diverticular Disease and Complications
- Dialysis and Renal Disease Management
- Photodynamic Therapy Research Studies
- Inflammatory Bowel Disease
- Advanced MRI Techniques and Applications
- Colorectal and Anal Carcinomas
Charité - Universitätsmedizin Berlin
2019-2024
Humboldt-Universität zu Berlin
2021
Freie Universität Berlin
2021
Objective: To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline. Background: SSI is a common complication after gastrointestinal surgery. date, there lack of evidence beneficial terms reduction SSI. Methods: The RECIPE trial was an investigator initiated single-center, single-blind prospective, randomized controlled 2 parallel treatment groups, comparing 0.9% saline...
Objectives: The COVID-19 pandemic and its associated restrictions have resulted in delayed diagnoses across various tumor entities, including rectal cancer. Our hypothesis was based on the expectation of a reduced number primary operations due to higher stages compared control group. Methods: In single-center retrospective study conducted from 1 March 2018 2022, we analyzed 120 patients with an initial diagnosis Among them, 65 were part group (pre-COVID-19), while 55 included (during...
Myopathy, characterised by altered mitochondrial function, is a central part of the pathophysiology peripheral arterial disease and aim this study was to investigate effect revascularisation on function.High resolution respirometry used respiration results were normalised citrate synthase activity (CSA), marker content. Ten patients with symptomatic (study group) 10 subjects without ischaemia (control included. Ankle brachial index ultrasound imaging performed before after vascular...
With the onset of COVID pandemic in Germany March 2020, far-reaching restrictions were imposed that limited medical access for patients. Screening examinations such as colonoscopies greatly reduced number. As rapid surgical triage after diagnosis is prognostic, our hypothesis was pandemic-related delays would increase proportion advanced colon cancers with an overall sicker patient population.A total 204 patients initial cancer analyzed this retrospective single-center study between...
Abstract Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity graded based on clinical manifestation. To investigate the influence different stages myopathy ischemic muscle we analysed severity‐dependent effects mitochondrial respiration in PAD. Eighteen patients with severe PAD, defined as chronic limb‐threatening ischemia, 47 intermittent claudication (IC) 22 non‐ischemic controls were analysed. High‐resolution respirometry (HRR) was performed biopsies...
Abstract Background Peripheral arterial disease (PAD) is accompanied by myopathy characterized mitochondrial dysfunction. The aim of this experimental study was to investigate the effect revascularization procedures on function in ischemic and non-ischemic muscle. Methods Muscle biopsies from patients with symptomatic stage IIB/III PAD caused isolated pathologies superficial femoral artery were obtained muscle regions within chronic (gastrocnemius) (vastus lateralis) before 6 weeks after...
Mechanisms of lymph node invasion seem to play a prognostic role in pancreatic ductal adenocarcinoma (PDAC) after resection. However, the 8th edition TNM classification American Joint Committee on Cancer (AJCC) does not consider this. The aim this study was analyse different mechanisms PDAC. One hundred and twenty-two patients with resected PDAC were examined. We distinguished three groups: direct (per continuitatem, Nc) from main tumour, metastasis (Nm) without any contact mixed mechanism...
Abstract Purpose Colorectal cancer revealed over the last decades a remarkable shift with an increasing proportion of right- compared to left-sided tumor location. In current study, we aimed disclose clinicopathological differences between and colon (rCC lCC) respect mortality outcome predictors. Methods total, 417 patients stage I–IV were analyzed in present retrospective single-center study. Survival rates assessed using Kaplan–Meier method uni/multivariate analyses performed Cox...
Atherosclerotic peripheral arterial disease (PAD) leads to intermittent claudication (IC) and may progress into chronic limb-threatening ischemia (CLTI). Scoring systems determine the atherosclerotic burden of a diseased extremity have been developed. This study aimed evaluate modification run-off resistance (mROR) score for its usability in cross-sectional imaging. The mROR was determined from preoperative imaging patients undergoing revascularization PAD. A total 20 with IC CLTI were...
High Resolution Respiratory has been shown as an effective tool to measure the mitochondrial respiration in striated muscle, well measurement of citrate synthase activity (CSA) give information amount mitochondria a tissue.
Postoperative Wundinfektionen (WI) sind eine häufige Komplikation in der Viszeralchirurgie. Aktuell gibt es nur geringe Evidenz zur Wertigkeit subkutaner antiseptischer Wundspülungen bei abdominalchirurgischen Operationen.