A5084697841- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Electrospun Nanofibers in Biomedical Applications
- Peripheral Artery Disease Management
- Infectious Aortic and Vascular Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Muscle and Compartmental Disorders
- Abdominal vascular conditions and treatments
- Vascular Procedures and Complications
- Acute Kidney Injury Research
- Bladder and Urothelial Cancer Treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Cardiac and Coronary Surgery Techniques
- Microscopic Colitis
- Angiogenesis and VEGF in Cancer
- Renal and Vascular Pathologies
- Connective tissue disorders research
- Biliary and Gastrointestinal Fistulas
- Multiple and Secondary Primary Cancers
- Vasculitis and related conditions
- Cardiac Ischemia and Reperfusion
Charité - Universitätsmedizin Berlin
2017-2025
Humboldt-Universität zu Berlin
2017-2022
Freie Universität Berlin
2017-2022
RELX Group (Netherlands)
2021
RWTH Aachen University
2012-2015
Institute for Biomedical Engineering
2012
Peripheral arterial disease encompasses different clinical symptoms, depending on the severity of disease. In early stages, a walking-induced pain, known as intermittent claudication, is leading symptom. Repeating cycles ischemia and reperfusion induce typical myopathy, with mitochondria playing key role within this pathophysiological condition. The aim study to further evaluate effects treatment strategies mitochondrial function overall cardiovascular outcomes randomized controlled trial....
The renin–angiotensin system (RAS) and obesity have been implicated in vascular outward remodeling, including aneurysms, but the precise mechanisms are not yet understood. We investigated effect of angiotensin receptor type 1 (AT1-receptor) antagonist telmisartan on aortic remodeling a diet-induced model mice. C57/Black6J mice were fed either low-fat diet (LFD) or high-fat (HFD) for 14 weeks. One group HFD was additionally exposed to (3 mg/kg per day) last 4 led characterized by increased...
Myopathy, characterised by altered mitochondrial function, is a central part of the pathophysiology peripheral arterial disease and aim this study was to investigate effect revascularisation on function.High resolution respirometry used respiration results were normalised citrate synthase activity (CSA), marker content. Ten patients with symptomatic (study group) 10 subjects without ischaemia (control included. Ankle brachial index ultrasound imaging performed before after vascular...
Purpose: In some cases of endovascular thoracoabdominal or juxtarenal aortic aneurysm repair, a thoracic endograft in combination with fenestrated renovisceral device may be needed order to create sufficient proximal landing zone. This study aimed evaluate the technical aspects and postoperative morbidity single- 2-stage approach. Methods: Eighty-seven consecutive patients undergoing repair (TEVAR) elective (fenestrated [FEVAR]; Anaconda device) from 2015 2022 were included this...
Abstract Background So called “mycotic” aortic aneurysms account for only 0.7 to 1.3% of all and are commonly caused by Staphylococcus aureus Salmonella species. Bacillus Calmette-Guérin (BCG), a live attenuated strain Mycobacterium bovis , is part the therapy non-muscle-invasive bladder cancer (NMIBC). Case presentation We report case series three patients with mycobacterial graft infection related BCG after surgical treatment presumed mycotic aneurysm as an extremely rare complication...
Abstract Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity graded based on clinical manifestation. To investigate the influence different stages myopathy ischemic muscle we analysed severity‐dependent effects mitochondrial respiration in PAD. Eighteen patients with severe PAD, defined as chronic limb‐threatening ischemia, 47 intermittent claudication (IC) 22 non‐ischemic controls were analysed. High‐resolution respirometry (HRR) was performed biopsies...
Abstract Cytokine-mediated systemic inflammation after open thoracoabdominal aortic aneurysm (TAAA) repairs plays a pivotal role in disrupting circulatory homeostasis, potentially leading to organ dysfunction. The bioactive form of adrenomedullin (bio-ADM) is peptide hormone with immunomodulatory and vasomotor effects, making it potential diagnostic agent these cases. This retrospective, bicentric study, conducted between January 2019 December 2022, recruited 36 elective TAAA repair patients...
Inflammation of the rectal remnant may affect postoperative outcome ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We aimed to determine extent inflammation anastomotic area during IPAA and investigate impact proctitis on complications long-term outcomes.Three hundred thirty-four UC primary were included this retrospective case-control study. The histopathologic degree was graded into three stages no ("NOP"), mild medium ("MIP"), severe ("SEP"). Preoperative...
To report and analyze the indications results of endovascular open surgical treatment for uretero-arterial fistula.We retrospectively reviewed clinical data 25 consecutive patients with fistulas admitted to our hospital from 2011 2020. Endpoints were technical success, freedom conversion, stent-graft/graft-related complications, 30-day one-year mortality.The study included (68% female, n = 17) 27 by bilateral pathologies in two patients. The mean age was 61 ± 11 years (range 35-80). most...
Background Endovascular aortic aneurysm repair (EVAR) has become the standard procedure for treating infrarenal abdominal aneurysms (AAA). Various associated complications can lead to open conversion (OC). Thorough follow-up after is mandatory early detection of complications. Persisting perfusion aneurysm, a so-called endoleak (EL), paired with structural instability because wall atrophy and impaired cell functionality induced by EVAR, results in high risk rupture. Purpose The goal this...
Abstract Background Peripheral arterial disease (PAD) is accompanied by myopathy characterized mitochondrial dysfunction. The aim of this experimental study was to investigate the effect revascularization procedures on function in ischemic and non-ischemic muscle. Methods Muscle biopsies from patients with symptomatic stage IIB/III PAD caused isolated pathologies superficial femoral artery were obtained muscle regions within chronic (gastrocnemius) (vastus lateralis) before 6 weeks after...
Acute kidney injury (AKI) is a common complication after complex aortic procedures and it associated with relevant mortality morbidity. Biomarkers for early specific AKI detection are lacking. The aim of this work to investigate the reliability NephroCheck bedside system diagnosing stage 3 following open surgery. In prospective, multicenter, observational study,- https://clinicaltrials.gov/ct2/show/NCT04087161 -we included 45 patients undergoing thoracoabdominal repair. risk (AKIRisk-Index)...
Endovascular repair (EVAR) has become the standard procedure in treating thoracic (TAA) or abdominal aortic aneurysms (AAA). Not entirely free of complications, a persisting perfusion aneurysm after EVAR, called Endoleak (EL), leads to reintervention and risk secondary rupture. How wall responds implantation stentgraft EL is mostly uncertain. We present pilot study identify peptide signatures gain new insights pathophysiological alterations EVAR using matrix-assisted laser desorption...
Acute kidney injury (AKI) after open thoracoabdominal aortic aneurysm repairs (TAAA) is a common postoperative complication, associated with increased mortality and morbidity. Early detection management of the tissue damage remains paramount importance. The aim this prospectively conducted, observational trial was to evaluate clinical applicability Proenkephalin A 119-159 (penKid) for AKI.
To report and compare the results of endovascular open surgical treatment for erosion bleeding visceral arteries following pancreatitis pancreatic surgery. This retrospective study included 65 consecutive patients (46 males, mean age 63 ± 14 years) presenting with artery erosions between January 2011 December 2020. Endpoints were technical success, freedom from reintervention, stent-graft-related complications, 30-day one-year mortality. The causes complications pancreas upper...
Aortoesophageal fistula (AEF) after thoracic endovascular aortic repair (TEVAR) is a rare complication associated with high mortality. Most well established treatment multi-staged surgery, including removal of infected stent graft, esophageal resection and reconstruction. We report on case 67-year-old patient AEF graft infection. Stent was infeasible due to the critical condition history multiple vascular procedures thoracoabdominal aorta. Surgical management included staged right left...
Trotz der herausragenden Forschung einer Vielzahl von Wissenschaftlern im interdisziplinären Forschungsfeld Implantatentwicklung ist das „ideale“ Implantat bis heute nicht verfügbar. Einen Ansatz auf dem Weg zu einem solchen stellt sog. „Tissue Engineering“ dar. Es basiert Nutzung körpereigener Zellen und setzt sich zum Ziel, die Geweberegeneration fördern oder gar nachzuahmen. Für Realisierung dieser zellbasierten Konstrukte werden Trägerstrukturen (sog. „Scaffolds“) benötigt, natürlichen...