A5071252822- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Atrial Fibrillation Management and Outcomes
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Galectins and Cancer Biology
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Mechanisms and Therapy
- Axon Guidance and Neuronal Signaling
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Digestive system and related health
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Fibrosis and Remodeling
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
Otto-von-Guericke University Magdeburg
1997-2024
An-Institut für Qualitätssicherung in der operativen Medizin
2024
Humboldt-Universität zu Berlin
2021-2023
Charité - Universitätsmedizin Berlin
2007-2023
Freie Universität Berlin
2021-2023
University of Catania
2022
Universitätsklinikum des Saarlandes
2022
University of Tübingen
2008
University Hospital Magdeburg
1997-2002
University of Münster
1989
Epithelial to mesenchymal transitions are vital for tumor growth and metastasis. Several inducers of epithelial transition transcription factors that repress E-cadherin expression, such as Snail, Slug, Twist. In this study, we aimed examine the expression these in pancreatic cancer.The Twist was detected by immunohistochemistry tissue samples from patients with ductal adenocarcinoma. Five human cancer cell lines (AsPC-1, Capan-1, HPAF-2, MiaPaCa-2, Panc-1) were analyzed reverse...
Background —Previous studies have suggested that atrial fibrillation (AF) is associated with the activation of angiotensin system. However, it not known whether expression II receptors changes during AF. The purpose this study was to determine type 1 and 2 (AT -R AT -R) in patients Methods Results —Atrial tissue samples from 30 undergoing open heart surgery were examined. Eleven had chronic persistent AF (≥6 months; cAF), 8 paroxysmal (pAF), 11 sinus rhythm. localized by immunohistochemistry...
Atrial fibrillation (AF) is accompanied by intracellular calcium overload. The purpose of this study was to assess the role calcium-dependent calpains and cytokines during AF. tissue samples from 32 patients [16 with chronic AF 16 in sinus rhythm (SR)] undergoing open heart surgery were studied. expression calpain I II, calpastatin, troponin T (TnT), C (TnC), [interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, transforming growth factor (TGF)-β1, tumor necrosis factor-α] determined. Expression...
Background — ADAMs ( A D isintegrin nd M etalloproteinase) are ectoproteases that have recently been reported to be expressed in cardiac tissue. Although they known regulate cell-cell and cell-matrix interactions, their pathophysiological role various diseases is unclear. The purpose of the present study was determine whether structural remodeling atria during atrial fibrillation (AF) associated with altered ADAM expression. Methods Results Atrial tissue samples 30 patients undergoing...
Interleukine-6 plays a key role in the progression and poor survival pancreatic ductal adenocarcinoma (PDAC). The present study aimed to clarify if targeting interleukin-6/glycoprotein-130 signaling cascade using small-molecule gp130 inhibitor SC144 or raloxifene, non-steroidal selective estrogen receptor modulator, enhances paclitaxel efficacy. MTT/BrdU assays TUNEL staining were performed investigate cell viability, proliferation apoptosis induction L3.6pl AsPC-1 human lines. In vivo,...
Alanyl aminopeptidase (APN, CD13) is highly expressed in human monocytes, and anti-CD13 monoclonal antibodies are well established routine markers leukaemia typing. Due to activation or malignant transformation other leukocyte subpopulations including T cells exhibit significant APN-gene surface expression. The function of APN poorly understood, especially the knowledge physiological ligands/substrates enzyme limited. Abnormal expression on lymphocytes, activation-dependent induction...
Cholinergic signaling via the muscarinic M3 acetylcholine receptor (M3R) is involved in development and progression of colorectal cancer (CRC). The present study aimed to analyze blocking M3R CRC using darifenacin, a selective antagonist. Darifenacin effects were studied on HT-29 SW480 cells MTT BrdU assays, Western blotting real time RT-PCR. In vivo, was assessed an orthotopic xenograft BALB/cnu/nu mouse model. expression clinical tumor specimens by immunohistochemistry tissue microarray...
Muscarinic acetylcholine receptor M3 (M3R) has repeatedly been shown to be prominently expressed in human colorectal cancer (CRC), playing roles proliferation and cell invasion. Its therapeutic targetability suggested vitro animal models. We aimed investigate the clinical role of MR3 expression CRC for survival. Surgical tissue samples from 754 patients were analyzed high or low immunohistochemical M3R on a clinically annotated microarray (TMA). Immunohistochemical analysis was performed...
Aminopeptidase inhibitors strongly affect the proliferation and function of immune cells in man animals are promising agents for pharmacological treatment inflammatory or autoimmune diseases. Membrane alanyl-aminopeptidase (mAAP) has been considered as major target these anti-inflammatory aminopeptidase inhibitors. Recent evidence also points to a role cytosol alanylaminopeptidase (cAAP) response. In this study we used quantitative RT-PCR determine mRNA expression both cAAP mAAP resting...
Abstract Purpose Interleukin 6 (IL-6), Oncostatin M (OSM), and downstream effector STAT3 are pro-tumorigenic agents in pancreatic ductal adenocarcinoma (PDAC). Glycoprotein 130 (gp130) is a compound of the IL-6 OSM receptor complex that triggers signaling. SC144 small molecule gp130 inhibitor with anticancer activity. This study examines expression human PDAC specimens vitro effects cell lines. Methods Tissue micro-arrays were constructed from 175 resected PDAC. The tumor epithelium stroma...
The TNF-superfamily member TRAIL is known to mediate selective apoptosis in tumor cells suggesting this protein as a potential antitumor drug target. However, initial successful pr-clinical results could not be translated into the clinic. Reasons for ineffectiveness of TRAIL-targeting therapies include acquired resistance. A cell acquires resistance, example, by upregulation antiapoptotic proteins. In addition, can also influence immune system and thus, growth. We were able show our previous...
Objectives. Restoration of the macro- and microcirculation is important for healing gastrointestinal anastomoses. Colloids crystalloids are widely used blood volume therapy. We evaluated effects human albumin, hydroxyethyl starch (HES) 130/0.4 saline on wound in colon anastomoses rats. Material methods. Male Wistar rats received a colonic end-to-end anastomosis. The animals were randomized into three groups single 3-ml dose either 20% 6% HES or 0.9% was applied intravenously. Six, 24, 48, 96...