A5008040368- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Fibrosis and Remodeling
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neuropharmacology Research
- HER2/EGFR in Cancer Research
- Antiplatelet Therapy and Cardiovascular Diseases
- CAR-T cell therapy research
- Hepatitis Viruses Studies and Epidemiology
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- Hematopoietic Stem Cell Transplantation
- Advanced Proteomics Techniques and Applications
- RNA regulation and disease
- Hepatitis B Virus Studies
- Antifungal resistance and susceptibility
University of Lower Silesia
2024
Otto-von-Guericke University Magdeburg
2010-2023
University Hospital Magdeburg
2006-2018
Klinikum Magdeburg
2014
Charité - Universitätsmedizin Berlin
2008
Klinikum rechts der Isar
2008
Technical University of Munich
2008
Data from animal experiments and clinical investigations suggest that components of the renin-angiotensin system are markedly affected by sex hormones. However, whether estrogen affects human atrial myocardium has not been investigated yet. In this study, we determined effects on key system: angiotensin-converting enzyme, responsible for generation angiotensin II enzyme 2, counteracting majority AngII effects, different receptors, AT1R, AT2R, MAS. First, expression levels receptors mRNA were...
Cigarette smoking (CS) promotes endothelial dysfunction and atherosclerosis in the vascular bed. The impact of on atrial myocardium is not defined humans.To determine effect CS development interstitial fibrosis myocardium.Case-control study.95 patients (46 smokers 49 non-smokers) undergoing coronary artery bypass grafting (CABG).Amount fibrosis, collagen I, III IV expression pattern, quantitative reverse transcriptase-PCR. Occurrence postoperative fibrillation (AF).In study population,...
AimsPatients with paroxysmal atrial fibrillation (AF) often present typical angina pectoris and mildly elevated levels of cardiac troponin (non ST-segment elevation myocardial infarction) during an arrhythmic event. However, in a large proportion these patients, significant coronary artery disease is excluded by angiography. Here we explored the potential underlying mechanism events.
Activated factor X (FXa) is an important player in the coagulation cascade responsible for thrombin generation, which activated during atrial fibrillation. Increasing evidence suggests that FXa influences cell signalling various types by activating protease-activated receptors (PARs). It so far not known if molecular effects of affect signal transduction. To study FXa, human tissue slices were cultivated with up to 24 h. Additionally, rapid pacing was applied at 4 Hz resemble The inhibitory...
Background— Increased levels of inflammatory markers are predictors thromboembolic events during atrial fibrillation (AF). endocardial expression adhesion molecules (ie, vascular cell molecule [VCAM] and intercellular [ICAM]) could be an important link between initiation prothrombogenic mechanisms responsible for thrombus development at the endocardium (endocardial remodeling). Methods Results— Tissue microarrays were used to screen right tissue specimens obtained from 320 consecutive...
In the central nervous system (CNS), neuregulin-1 (NRG-1) proteins function in neuronal migration, differentiation, and survival of oligodendrocytes. The NRG-1 gene codes for at least 15 different isoforms, which may be classified on basis their molecular structure. At two haplotypes associated with schizophrenia. An abnormal expression pattern mRNA was found prefrontal cortex schizophrenic patients comparison to controls. We here show that NRG-1alpha isoform is significantly reduced white...
Accumulating evidence links calcium-overload and oxidative stress to atrial remodeling during fibrillation (AF). Furthermore, appears increase thrombogeneity, characterized by increased expression of adhesion molecules. The aim this study was assess mitochondrial dysfunction stress-activated signal transduction (nuclear factor-kappaB [NF-kappa B], lectin-like oxidized low-density lipoprotein receptor [LOX-1], intercellular molecule-1 [ICAM-1], hemeoxgenase-1 [HO-1]) in tissue AF. Ex vivo...
Hypertension is a major risk factor for atrial fibrillation. We hypothesized that arterial hypertension would alter myocyte calcium (Ca2+) handling and these alterations serve to trigger tachyarrhythmias.Left atria or left (LA) myocytes were isolated from spontaneously hypertensive rats (SHR) normotensive Wistar-Kyoto (WKY) controls. Early after the onset of hypertension, at 3 months age, there no differences in Ca2+ transients (CaTs) expression phosphorylation proteins between SHR WKY. At 7...
Telmisartan, in addition to blocking angiotensin (Ang) II type 1 receptor (AT R), activates peroxisome proliferator activated γ (PPARγ) signaling that interferes with nitric oxide (NO) system. Because aging of endothelial cells (ECs) is hallmarked by a reduction NO synthesis, we hypothesized telmisartan increases formation regulated asymmetrical dimethylarginine (ADMA)-dimethylarginine dimethylaminohydrolase (DDAH)-system through AT R and activating PPARγ signaling. To test this hypothesis,...
In spontaneously hypertensive rats (SHR) atrial remodeling has been shown to involve increase in endothelin (ET) signaling. Furthermore, inflammatory processes may further contribute tissue remodeling. The aimed of this study was investigate whether an receptor antagonist, macitentan, could reduce left (LA) arterial hypertension.Molecular characterization atria performed SHR at the age 8 months and their age-matched normotensive control (WKY). were treated with macitentan and, for comparison...
Patients with atrial fibrillation (AF) often present typical angina pectoris and mildly elevated levels of cardiac troponin (non-ST-segment elevation myocardial infarction) during an acute episode AF. However, in a large proportion these patients, significant coronary artery disease is excluded by angiography, which suggests that AF itself influences blood flow. The review summarizes the effect on occurrence ventricular oxidative stress, redox-sensitive signaling pathways gene expression,...
Atrial fibrillation induces ischaemic microcirculatory flow abnormalities in the ventricle, contributing to risk for acute coronary syndromes. We evaluated effect of dronedarone on ventricular perfusion during rapid atrial pacing (RAP).
Recent studies suggest that atrial fibrillation (AF) substantially influences microvascular flow in ventricular myocardium. This process may contribute to the occurrence of heart failure AF. In general, development and renal dysfunction go hand-in-hand causing systemic fluid overload oedema. So far, it is unknown whether AF itself function. The aim present study was determine impact on gene expression a closed chest rapid pacing model.A total 14 pigs were studied. five pigs, (AT) performed...