Stéphane N. Hatem
A5003159972- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Phosphodiesterase function and regulation
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Muscle Physiology and Disorders
- Pain Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Genetic Neurodegenerative Diseases
Inserm
2016-2025
Pitié-Salpêtrière Hospital
2015-2025
Sorbonne Université
2016-2025
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2016-2025
Assistance Publique – Hôpitaux de Paris
2014-2024
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2014-2024
Sorbonne University Abu Dhabi
2016-2024
Université Paris 1 Panthéon-Sorbonne
2021-2023
Université Sorbonne Paris Nord
2020-2022
Laboratoire d’Imagerie Biomédicale
2015-2021
Recent studies have reported a relationship between the abundance of epicardial adipose tissue (EAT) and risk cardiovascular diseases including atrial fibrillation (AF). However, underlying mechanisms are unknown. The aim this study was to examine effects secretome human EAT on histological properties myocardium. Samples subcutaneous (SAT), obtained from 39 patients undergoing coronary bypass surgery, were analysed tested in an organo-culture model rat atria evaluate fibrotic fat depots....
The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. 3 last residues of (Ser-Ile-Val) constitute PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at intercalated discs, could potentially interact other, yet unknown, proteins this site.The aim study was to determine whether part distinct regulatory complexes lateral membranes discs.Immunostaining experiments demonstrated localizes cardiomyocytes syntrophin....
Accumulation of atrial adipose tissue is associated with fibrillation (AF). However, the underlying mechanisms remain poorly understood. We examined relationship between characteristics fatty infiltrates myocardium and history AF. Atrial samples, collected in 92 patients during cardiac surgery a sheep model persistent AF, were subjected to detailed histological analysis. In sections human right subepicardial infiltrations commonly observed majority patients. A clear difference appearance...
Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, atria, coronary arteries. Its abundance linked artery disease (CAD) atrial fibrillation. However, its physiological function remains highly debated. The aim of this study was determine specific EAT transcriptomic signature, depending anatomical peri-atrial (PA), peri-ventricular (PV), or peri-coronary location. Samples thoracic subcutaneous fat, obtained from 41 patients...
Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity mortality even on optimal current therapy. This document summarizes key outcomes 8th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Eighty-three international experts met Hamburg for 2 days October 2021. Results interdisciplinary, hybrid discussions breakout groups plenary...
Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have...
Abstract Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated risk AF-related complications. The aim this document to summarize key outcomes 9th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Methods results Eighty-three international experts met Münster for 2 days September 2023. Key findings...
Aims Congestive heart failure (CHF) is associated with severe structural changes of atria, contributing to impaired atrial function and the risk arrhythmia. This study investigated effects CHF treatments on remodelling. Methods results Three months after myocardial infarction (MI), rats were treated for 1 month spironolactone, lisinopril, or atenolol alone in combination. Echocardiography–Doppler tissue imaging, haemodynamic measurements, 24-h Holter monitoring used characterize...
Cardiac Ca2+ current (I") was shown to be regulated by cGMP in a number of different species.Recently, we found that the NO-donor SIN-1 (3-morpholino-sydnonimine) ex- erts dual regulation Ic. frog ventricular myocytes via an accumulation cGMP.To examine whether NO also regulates Ca2" channels human heart, investigated effects on isolated atrial myocytes.An extracellular application produced profound stimulatory effect basal IC. at concentrations > 1 pM.Indeed, 10 pM induced s 35% increase...
Background— Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes α-subunit of cardiac sodium channel Na v 1.5. However, ≈20% probands have mutations, suggesting implication other genes. MOG1 recently was described as a new partner 1.5, playing potential role regulation its expression and trafficking. We investigated whether could cause BrS. Methods Results— screened direct sequencing patients with BrS idiopathic ventricular fibrillation. A missense mutation...
Background: Aging induces cardiac structural and functional changes linked to the increased deposition of extracellular matrix proteins, including OPN (osteopontin), conducing progressive interstitial fibrosis. Although is involved in various pathological conditions, its role myocardial aging remains unknown. Methods: deficient mice (OPN-/-) with their wild-type (WT) littermates were evaluated at 2 14 months age terms structure, function, histology key molecular markers. expression was...
The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction new oral anticoagulants, antiarrhythmic drugs, and emergence catheter ablation as a common intervention for rhythm control. Furthermore, technologies enhance our ability to detect AF. Most clinical decisions AF patients can be based on validated parameters that encompass type presentation, factors, electrocardiogram analysis, cardiac imaging. Despite these advances, are still at increased...
The atria provide an important contribution to cardiac function [1], [2]. Besides their impact on ventricular filling, they serve as a volume reservoir, host pacemaker cells and parts of the conduction system (e.g. sinus node, AV node), secrete natriuretic peptides like atrial peptide (ANP) brain (BNP) that regulate fluid homoeostasis. Atrial myocardium is affected by many non-cardiac conditions [3] is, in some respects, more sensitive than [4]. are activated, besides three specialised...
There are major challenges ahead for clinicians treating patients with atrial fibrillation (AF). The population AF is expected to expand considerably and yet, apart from anticoagulation, therapies used in have not been shown consistently impact on mortality or reduce adverse cardiovascular events. New approaches management, including the use of novel technologies structured, integrated care, potential enhance clinical phenotyping result better treatment selection stratified therapy. Here, we...