A5020955394- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Porphyrin Metabolism and Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Neurotransmitter Receptor Influence on Behavior
- X-ray Diffraction in Crystallography
- Cardiovascular Function and Risk Factors
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Congenital Heart Disease Studies
- Estrogen and related hormone effects
- Neonatal Health and Biochemistry
- Folate and B Vitamins Research
- Heart Rate Variability and Autonomic Control
- Heme Oxygenase-1 and Carbon Monoxide
- Photosynthetic Processes and Mechanisms
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Crystallography and molecular interactions
- Transplantation: Methods and Outcomes
Michael E. DeBakey VA Medical Center
2025
Baylor College of Medicine
2025
Penn State Milton S. Hershey Medical Center
2015-2024
University of Massachusetts Amherst
2023
Instituto Nacional de Psiquiatría
2021
Pennsylvania State University
2001-2019
Organix (United States)
1996-2018
Scott & White Memorial Hospital
2016
Baylor Medical Center at Garland
2016
Brigham and Women's Hospital
2008
Background— Recurrent ventricular tachycardia (VT) is an important cause of mortality and morbidity late after myocardial infarction. With frequent use implantable cardioverter-defibrillators, these VTs are often poorly defined not tolerated for mapping, factors previously viewed as relative contraindications to ablation. This observational multicenter study assessed the outcome VT ablation with a saline-irrigated catheter combined electroanatomic mapping system. Methods Results— Two hundred...
ECG Localization of Accessory AV Pathways. Introduction : Delta wave morphology correlates with the site ventricular insertion accessory pathways. Because lesions due to radiofrequency (RF) current are small and well defined, it may allow precise localization The purpose this study was use RF catheter ablation develop an algorithm predict pathway location. Methods Results An developed by correlating a resting 12‐lead successful in 135 consecutive patients single, anterogradely conducting...
Background Typical atrial flutter (AFL) results from right reentry by propagation through an isthmus between the inferior vena cava (IVC) and tricuspid annulus (TA). We postulated that eustachian valve ridge (EVR) forms a line of conduction block IVC coronary sinus (CS) ostium second (septal isthmus) TA CS ostium. Methods Results Endocardial mapping in 30 patients with AFL demonstrated activation around counterclockwise direction (left anterior oblique projection). Double potentials were...
Differentiation between ventriculoatrial (VA) conduction over an accessory AV pathway (AP) and the node (AVN) may be difficult, especially in patients with a septal AP.A new pacing method, para-Hisian pacing, was tested 149 AP 53 without who had nodal reentrant tachycardia (AVNRT). Ventricular performed adjacent to His bundle proximal right branch (HB-RB), initially at high output capture both RV HB-RB. The then decreased lose HB-RB capture. change timing sequence of retrograde atrial...
The atria provide an important contribution to cardiac function [1], [2]. Besides their impact on ventricular filling, they serve as a volume reservoir, host pacemaker cells and parts of the conduction system (e.g. sinus node, AV node), secrete natriuretic peptides like atrial peptide (ANP) brain (BNP) that regulate fluid homoeostasis. Atrial myocardium is affected by many non-cardiac conditions [3] is, in some respects, more sensitive than [4]. are activated, besides three specialised...
We conducted this pilot randomized clinical trial to determine the feasibility of a large aimed at testing whether early use catheter ablation ventricular tachycardia (VT) is superior antiarrhythmic medications reducing mortality.Patients were enrolled 4 sites if they had ischemic heart disease, an implantable cardioverter defibrillator (ICD), and received ≥1 ICD shock or ≥3 antitachycardia pacing therapies for VT. Patients 2 arms: (1) medication (n = 14) (2) 13); patients followed 3 6...
Abstract Background Cardiac troponin I (Tn) is a biomarker for myocardial injury, often elevated in acute coronary syndrome (ACS), sepsis, and respiratory viral infection (ARI). The significance of Tn patients admitted with ARI not clear. We evaluated readmission due to cardiovascular (CV) events (ACS, heart failure (HF), or stroke) all-cause mortality hospitalized on admission. Methods This 2-VA site sub-study SUPERNOVA (Surveillance Platform Enteric Respiratory Infectious Organisms the...
The purpose of this study was to determine how often accessory atrioventricular (AV) pathways (AP) cross the AV groove obliquely. With an oblique course, local ventriculoatrial (VA) interval at site earliest atrial activation (local-VA) and local-AV ventricular (local-AV) should vary by reversing direction paced wavefronts, respectively.One hundred fourteen patients with a single AP were studied. Two two pacing sites on opposite sides selected reverse wavefronts along annulus. Reversing...
At the mitral annulus-aorta (MA-Ao) junction, left atrium is continuous through subaortic curtain with musculature of anterior leaflet. Under experimental conditions, this region can generate abnormal electrical activity. In patients atrial tachycardia, we investigated whether could be source arrhythmia.In 10 (28%) 35 consecutive arrhythmia originated from MA-Ao junction. Sustained, self-limited episodes tachycardia (cycle length, 340+/-56 ms; duration, 125+/-69 seconds) were repeatedly...
The abnormal development of the tricuspid valve in patients with Ebstein's anomaly results several activation abnormalities including delayed intraatrial conduction, right bundle branch block (RBBB), and ventricular preexcitation. aim present study was to define ECG characteristics before after ablation an accessory A-V pathway (AP) anomaly.A series 226 consecutive studied. Sixty-four (28%) had documented tachycardia. Thirty-three recurrent tachycardia were found have a single right-sided AP...
Compound 1 was previously reported to be a potent inhibitor of cPLA(2)alpha in both artificial monomeric substrate and cell-based assays. However, inactive whole blood assays used characterize cyclooxygenase lipoxygenase inhibitors. The IC(50) increased dramatically with cell number or lipid/detergent concentration. In an attempt insert electrophilic ketone between the indole benzoic acid moieties, we discovered that increasing distance two moieties gave compound activity GLU...
Dofetilide Reduces VT/VF and ICD Therapies . Background: Patients with an implanted cardioverter defibrillator (ICD) ventricular arrhythmias leading to therapies have poor clinical outcomes quality of life. Antiarrhythmic agents catheter ablation are needed control these arrhythmias. has only been approved for the treatment atrial fibrillation. The role dofetilide in patients not established. Objective: Evaluate safety efficacy a consecutive group recurrent tachycardia (VT) and/ or...
Cocaine is a potent stimulant of the mammalian central nervous system. Its reinforcing and properties have been associated with its propensity to bind monoamine transporter systems. It has generally assumed that amino function on monoamines requirement for binding transporters. In particular, 8-amino tropane skeleton cocaine analogs provide an ionic bond aspartic acid residue dopamine (DAT). We prepared first 8-oxa 3-aryltropanes (WIN compounds) found 3β-(3,4-dichlorophenyl) (6g)...
The active site of porphobilinogen (PBG)1 deaminase (EC 4.3.1.8) from Escherichia coli has been found to contain an unusual dipyrromethane derived four molecules 5-aminolevulinic acid (ALA) covalently linked Cys-224, one the two cysteine residues conserved in E. and human deaminase. By use a hemA- strain enzyme was enriched [5-13C]ALA examined by 1H-detected multiple quantum coherence spectroscopy, which revealed all salient features composed PBG units head tail terminating CH2-S bond...
Bidirectional ventricular tachycardia (BVT), although a rare arrhythmia in the general population, is frequently observed patients with Andersen‐Tawil syndrome and long QT interval. However, pharmacologic treatment of this remains unknown. In present study, we documented favorable antiarrhythmic action flecainide young woman sustained BVT syndrome. She presented incessant that could only be terminated flecainide. During sinus rhythm, prolonged interval was observed. Genetic studies revealed...
Dronedarone is an amiodarone analog but differs structurally from in that the iodine moiety was removed and a methane-sulfonyl group added. These modifications reduced thyroid other end-organ adverse effects makes dronedarone less lipophilic, shortening its half-life. has been shown to prevent atrial fibrillation/flutter (AF/AFl) recurrences several multi-center trials. In addition rhythm control properties, rate properties slows ventricular response during AF. approved Europe for...
In brain, monoamine transporters are principal targets of widely used therapeutic drugs including antidepressants, methylphenidate (Ritalin), and the addictive drug cocaine. Without exception, these transport blocking agents contain an amine nitrogen. A prevalent view untested promise is that amino nitrogen needed to bind same counterion on transporter as does neurotransmitter. We report several compounds without (8-oxa-bicyclo-3-aryl-[3.2.1] octanes, or aryloxatropanes) active at...
Recent observations indicate that cannabis use can result in cardiovascular complications including arrhythmias. We studied the relationship between disorder (CUD) and arrhythmia hospitalization.We conducted a retrospective analysis of Nationwide Inpatient Sample (2010-2014). Patients (age 15-54) with primary diagnosis for (N = 570,556) were compared non-arrhythmia 67,662,082) inpatients odds ratio (OR) CUD by logistic regression model, adjusted demographics comorbid risk factors.The...