A5062765614- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- COVID-19 and healthcare impacts
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- Cardiomyopathy and Myosin Studies
- Hip and Femur Fractures
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- IL-33, ST2, and ILC Pathways
Showa University
2022-2024
National Hospital Organization
2015-2023
Tokyo University of Pharmacy and Life Sciences
2019-2023
Tokyo Medical and Dental University
2021-2023
Showa Pharmaceutical University
2023
University of Gothenburg
2016-2018
Surugadai Nihon University Hospital
2005-2011
Nihon University
2005-2009
University of Oklahoma Health Sciences Center
1996-2003
Lung Institute
1996-1998
Background Typical atrial flutter (AFL) results from right reentry by propagation through an isthmus between the inferior vena cava (IVC) and tricuspid annulus (TA). We postulated that eustachian valve ridge (EVR) forms a line of conduction block IVC coronary sinus (CS) ostium second (septal isthmus) TA CS ostium. Methods Results Endocardial mapping in 30 patients with AFL demonstrated activation around counterclockwise direction (left anterior oblique projection). Double potentials were...
Clinical efficacy has driven the use of larger electrodes (7F, length > or =4 mm) for radiofrequency ablation, which reduces electrogram resolution and causes variability in tissue contact depending on electrode orientation. With active cooling, ablation size may be reduced. The purpose this study was to examine effect temperature lesion with saline irrigation used cooling.In 11 anesthetized dogs, thigh muscle exposed bathed heparinized canine blood. A 7F catheter a 2- 5-mm irrigated tip...
Abstract Purpose The Database Task Force of the Japan Society for Pharmacoepidemiology began its annual surveys databases available clinico and pharmacoepidemiological studies in 2010. In this report, we summarize characteristics based on results our 2021 survey to illustrate recent developments infrastructure database research Japan. Methods We included 20 major from academia, government, or industry that were accessible third parties. used a web‐based questionnaire ask providers about...
The authors hypothesized that during RF ablation, the electrode to tissue interface temperature may significantly exceed in presence of cooling blood flow and produce thrombus. In 12 anesthetized dogs, skin over thigh muscle was incised raised form a cradle superfused with heparinized canine (ACT > 350 s) at 37°C. A 7 Fr, 4‐mm or 8‐mm ablation containing thermocouple held perpendicular 10‐g contact weight. Interface measured opposite sides using tiny optical probes. applications (n = 157)...
Numerous studies have been conducted in many countries to identify the factors associated with readmission of patients heart failure (HF). However, there no such utilizing a large-scale administrative database Japan. This study aimed establish 30-day HF using Japanese nationwide database. Data index admissions 68,257 discharged from 1057 participating hospitals between April 1, 2012 and March 31, 2013 were analyzed. Patients divided into group according whether unplanned occurred within 30...
Background Progression of unintentionally induced atrioventricular delay is occasionally observed directly after termination radiofrequency delivery in the vicinity node. We postulated that application a pulse may result tissue temperature rise continues pulse. Methods and Results Using thigh muscle preparation, 5-, 10-, 20-, 30-second pulses were applied at 30 to 40 W via standard 4-mm tip electrode with 10-g contact pressure. Forty-one undisturbed delivered while recording intramural...
In April 2014, sodium-glucose cotransporter 2 inhibitor (SGLT-2i) was introduced in Japan. May 2015, the prescription limitation for SGLT-2i lifted. Subsequently, shown to reduce cardiovascular events patients with type diabetes mellitus (T2DM). is expected increase and consequently affect trends other antidiabetic agents. Therefore, we evaluated agent prescriptions Japan from 2012 March 2020. this study, a dynamic cohort consisting of T2DM derived Medical Data Center health insurance...
Background Computed tomography (CT) is widely used in clinical practice, but there has not been a detailed report of its effect on the functioning pacemakers. Methods and Results During CT, ECGs were recorded 11 patients with pacemakers electromagnetic field CT room was also measured. The pacemaker investigated human body model without shielding by rubber or lead. Transient malfunctions during occurred 6 patients. showed that malfunctioning induced scanning this prevented lead rubber....
Studies have shown the efficacy of asthma biologics in real-world settings, confirming generalizability randomized controlled trial (RCT) results, but studies on more than one biologic are scarce. Accordingly, little is known about different background characteristics users biologics. This study aimed to describe backgrounds patients using (omalizumab, mepolizumab, benralizumab, and dupilumab) examine effectiveness these for reducing exacerbations total systemic corticosteroid doses.We...
目的:バリデーション研究は,医療情報データベース (DB) を用いる研究・製造販売後調査の信頼性を高めるために必要となることがある.日本薬剤疫学会はタスクフォースを設置し,日本でのバリデーション研究の在り方を検討した.
Oral mucositis (OM) is a common side effect in patients with cancer receiving chemotherapy and radiotherapy; however, no salivary mediator known to be associated OM. We aimed determine candidate inflammatory mediators potentially OM cancer. To this end, we compared the relationships between grade, oral mucosal dryness, (Interleukin (IL)-1β, IL-6, IL-10, IL-12p70, tumor necrosis factor (TNF), prostaglandin E2, vascular endothelial growth factor) healthy volunteers (HV). collected saliva...
Background: Selecting optimal biologics based on type 2 biomarkers has been of interest in severe asthma treatment.However, few direct biomarker stratification-based comparisons have made. Objective:To compare the effectiveness anti-IL-5 (mepolizumab, benralizumab), omalizumab, and dupilumab reducing number hospitalizations from exacerbations across all eosinophil-stratified subgroups.Methods: A retrospective cohort study using National Hospital Organization database (2016-2020) was...
Background: This study aimed to reveal differences in the effectiveness of rehabilitation improving activities daily living (ADL) patients with acute stroke across age groups and propose age-appropriate strategies. Methods: observational analyzed nationwide administrative data inpatients admitted hospitals between April 1, 2018, March 31, 2020. The included average length sessions, weekly frequency initiation within 3 days. primary outcome was improvement Barthel Index (BI) score from...
Some aspects regarding the use of antiplatelet agents after coil embolization for subarachnoid hemorrhage during admission remain unclear. This study used diagnostic procedure combination (DPC) data to investigate safety and prognostic effects aspirin monotherapy P2Y12 inhibitor therapy on bleeding events. cross-sectional Japanese DPC assess patients who were hospitalized with received between April 2016 March 2020 (n = 4421). The (A group, n 2848) (AP 1573) groups compared. primary...
Purpose: Maintaining independence after hip fracture repair is important for geriatric patients and general welfare. We investigated the effects of anesthetic methods on postoperative activities daily living (ADLs) following surgery in elderly patients. Methods: The medical records 12,342 aged ≥65 years who underwent typical surgeries using either anesthesia or spinal were reviewed. To adjust baseline differences minimize selection bias chosen method anesthesia, matched by propensity scores....
Abstract Aim Despite advances in the management of liver diseases and changes etiology cirrhosis, few studies have updated prognosis cirrhosis. This study aimed to clarify recent cirrhosis identify risk factors for death. Methods In this retrospective observational by Hepatic Disease Network National Hospital Organization Japan, chart reviews were performed follow patients with beginning 2011. We conducted Kaplan–Meier survival time analyses stratified Child–Pugh classification...
Appropriate treatment of stroke immediately after its onset contributes to the improved chances, while delay in hospitalisation affects severity and fatality. This study aimed determine impact coronavirus disease 2019 (COVID-19) pandemic on emergency patients with Japan.This was an observational that used nationwide administrative data hospitalised diagnosed stroke. We cross-sectionally observed patients' background factors during April May 2020, when COVID-19 pandemic-related state...