A5049350690- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Fatty Acid Research and Health
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Cancer, Lipids, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Disease and Adiposity
- Coronary Artery Anomalies
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Cardiomyopathy and Myosin Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Birth, Development, and Health
- Cardiovascular Effects of Exercise
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
Nihon University
2015-2024
Nippon Dental University
2024
Surugadai Nihon University Hospital
2012-2023
Japanese Circulation Society
2021
GTx (United States)
2017
Josai University
1990-2016
Cedars-Sinai Medical Center
2000-2004
University of California, Los Angeles
2004
Yamaguchi University
1991
Saiseikai Shimonoseki General Hospital
1991
Smoking increases the risk of atherothrombotic events. To determine whether smoking influences plaque thrombogenicity, we examined effect cigarette and aspirin use on tissue factor (TF) expression in atherosclerotic plaques.A total 23 apoE-/- mice were exposed to smoke with (n=9) or without (n=14) treatment. Eleven who filtered room air served as controls. Aortic root plaques had higher immunoreactivity for TF (14+/-4% versus 6.4+/-3%; P=0.0005), vascular cell adhesion molecule-1 (15+/-4%...
In the present study, multislice spiral computed tomography (MSCT), which allows non-invasive assessment of coronary artery plaque, was used to compare CT density plaque between patients with acute syndrome (acs) and those stable angina (sa).MSCT performed in 20 ACS (17 myocardial infarction, 3 unstable angina) 22 SA. The presence defined on basis multiplanar reformation axial images. At least 4 regions interest were then placed within minimum measured expressed as Hounsfield units (HU)....
Abstract Background The low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller size is associated with triglyceride (TG) metabolism disorders, often leading to atherogenesis. We investigated association between LDL-C/apoB and TG in coronary artery disease (CAD) patients diabetes mellitus (DM). Methods In cross-sectional study, ratio, which provides estimate size, was calculated 684 consecutive one...
In prior myocardial infarction (PMI) patients, diabetes mellitus (DM), dyslipidemia, and hypertension increase the risk of secondary cardiovascular events. Although a decreased ratio serum eicosapentaenoic acid (EPA) to arachidonic (AA; EPA/AA) has been shown significantly correlate with onset acute coronary syndrome, associations between polyunsaturated fatty (PUFA) levels factors in PMI patients have not evaluated thoroughly. This study aimed assess PUFAs patients. We enrolled 1733 known...
Ghrelin was recently isolated from the rat stomach as an endogenous ligand for GH secretagogue receptor. Although it is well known that a large amount of ghrelin produced in gastrointestinal tract, developmental changes mRNA expression and differentiation ghrelin-immunopositive (ghrelin-ip) mRNA-expressing (ghrelin-ex) cells have not been elucidated. In this study, we therefore investigated levels numbers ghrelin-ip -ex stomachs 1- to 8-week-old male female rats by Northern blot analysis,...
Background Multislice computed tomography (MSCT) was used to evaluate coronary artery remodeling in patients with acute syndrome (ACS) and stable angina (SA). Methods Results MSCT performed 31 ACS 26 SA intravascular ultrasound (IVUS) 28 of these 57 patients. In both the IVUS analyses, assessed by index (RI): RI >1.10 defined as positive (PCAR) <0.95 negative (NCAR). The closely correlated that (r=0.86, n=28). vessel area at region maximum luminal narrowing also comparable between...
Background: The purpose of this study was to explore the effect lifestyle modification, mainly daily aerobic exercise, on coronary atherosclerosis in patients with artery disease (CAD). Methods and Results: A 6-month prospective observational conducted 84 CAD receiving pravastatin treatment order evaluate relationship between particular plaque volume as assessed by intravascular ultrasound (IVUS). Lifestyle during period the-lifestyle modification score. significant decrease 12.9% observed...
Background: The purpose of this study was to evaluate the effect highly purified eicosapentaenoic acid (EPA) in increasing low-density lipoprotein (LDL) particle size, as one possible mechanisms by which intake EPA may prevent coronary events. Methods and Results: Hypertriglyceridemic subjects were randomly assigned a control group (n=72) or an (n=72; regimen 1,800mg/day for 6 months). In group, serum LDL-cholesterol high-density cholesterol levels remained unchanged, but there significant...
Background and aimHigher fish consumption has been reported to be associated with a lower incidence of coronary artery disease (CAD). We hypothesized that higher intake may serum level non-high-density lipoprotein cholesterol (non-HDL-C) levels, representing the entire dyslipidemia spectrum, healthy lifestyle.Methods resultsThis cross-sectional study was conducted in population 1270 apparently males over age 50 years without lipid-modifying therapy at Health Planning Center Nihon University...
Background Anomalous origins of the coronary artery are rare, but may cause myocardial ischemia and sudden death. Thus, their reliable identification is crucial for any imaging method that attempts visualization those available multislice computed tomography (MSCT), which provides excellent spatial resolution, be most promising. Methods Results In consecutive 1,153 patients, MSCT identified 5 patients (0.43 %) with an anomalous origin artery. The left circumflex (LCX) originated from right...
We investigated the role of inducible NO synthase (iNOS) in intimal thickening with exposure to cigarette smoke (CS).Intimal wild-type (WT) and iNOS-deficient (iNOS-/-) mice subjected CS was induced by placement a cuff around carotid artery. WT associated increased arterial iNOS expression, superoxide production, activator protein-1 (AP-1) activation, serum NO. Intimal 21 days after significantly greater exposed compared air (0.023+/-0.013 mm(2) versus 0.009+/-0.008 mm(2); P<0.05). inhibitor...
Low density lipoproteins (LDLs) are heterogeneous aggregations of molecules different particle sizes, and small-size LDLs more potent risk factors for atherosclerosis. We examined the qualitative characteristics in patients with stable coronary artery disease (CAD) receiving statin therapy. LDL-particle size was estimated based on LDL-cholesterol/apolipoprotein B ratio (LDL-C/apoB) 214 age-adjusted men The LDL-C/apoB significantly lower CAD (+) group (n = 107) than (-) (median, 1.17 versus...
We investigated the relationships between ratio of serum n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid [EPA] and docosahexaenoic [DHA]) to n-6PUFA (arachidonic [AA]) prevalence coronary artery disease (CAD), assessed association n-6 PUFAs with atherosclerosis-related markers.This study was designed as a hospital-based cross-sectional 649 consecutive outpatients who had undergone regular examinations April 2009 October 2009. divided patients into 5 groups based on quintiles...
A low eicosapentaenoic acid (EPA) to arachidonic (AA) ratio is a known risk for acute coronary syndrome (ACS). However, the association between docosahexaenoic (DHA) AA and ACS remains unclear. This study aimed assess DHA/AA by patient characteristics.We enrolled 1733 patients evaluated serum levels of polyunsaturated fatty acids in 5 cardiology departments metropolitan area Japan. We assessed relationship (median cut-off value: 0.903) according following 10 subgroups: sex, age, diabetes...