A5063608418- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Menopause: Health Impacts and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Lipid metabolism and disorders
- Connexins and lens biology
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
Institute of Clinical and Experimental Medicine
2015-2024
University Hospital in Motol
2017-2023
Charles University
2016-2021
Institute for Atherosclerosis Research
2006-2020
Ocní klinika
2020
Ministry of Health Labour and Welfare
2020
University of Hradec Králové
2018
University of Oklahoma
1995-2016
United States Department of Veterans Affairs
1979-2016
University of Oklahoma Health Sciences Center
1998-2014
The cardiotoxic effects of adriamycin were studied in 399 patients treated for far-advanced carcimma. Forty-five (11%) exhibited transient electrocardiographs changes. Eleven others developed severe congestive heart failure. Eight these latter died within 3 weeks the onset cardiac decompensation. diffuse nature this myocardiopathy was suggested by: 1. a conspicuous decrease QRS voltage on electrocardiograms; 2. rapidly occurring dilatation and ventricular failure, 3. refractoriness to...
Background— An open-irrigated radiofrequency (RF) ablation catheter was developed to measure contact force (CF). Three optical fibers microdeformation of the tip. The purpose this study (1) validate accuracy CF sensor (CFS) (bench test); and (2) determine relationship between tissue temperatures, lesion size, steam pop, thrombus during RF using a canine thigh muscle preparation. Methods Results— CFS measurements (total 1409) from 2 catheters in 3 angles (perpendicular, parallel, 45�) were...
Background It is thought that only a thin layer of tissue adjacent to the electrode heated directly by electrical current (resistive heating) during radiofrequency ablation. Most thermal injury result from conduction heat surface layer. The purpose this study was determine whether lesion depth could be increased producing direct resistive heating deeper in with higher power, allowed cooling ablation saline irrigation prevent rise impedance occurs when electrode-tissue interface temperature...
Background— Electrode-tissue contact force (CF) is believed to be a major factor in radiofrequency lesion size. The purpose of this study was determine, the beating canine heart, relationship between CF and size accuracy predicting by measuring electrogram amplitude, impedance, electrode temperature. Methods Results— Eight dogs were studied closed chest. Using 7F catheter with 3.5 mm irrigated sensor (TactiCath, St. Jude Medical), applications delivered 3 separate sites right ventricle (30...
Vagal stimulation shortens the atrial effective refractory period (AERP) and maintains fibrillation (AF). This study investigated whether parasympathetic pathways that innervate atria can be identified ablated by use of transvenous catheter radiofrequency current ablation (RFCA) techniques.In 11 dogs, AERPs were determined at 7 sites during bilateral cervical vagal nerve (VNS) electrical third fat pad (20 Hz) in right pulmonary artery (RPA). VNS shortened AERP all (from 123+/-4 to 39+/-4 ms,...
Background Typical atrial flutter (AFL) results from right reentry by propagation through an isthmus between the inferior vena cava (IVC) and tricuspid annulus (TA). We postulated that eustachian valve ridge (EVR) forms a line of conduction block IVC coronary sinus (CS) ostium second (septal isthmus) TA CS ostium. Methods Results Endocardial mapping in 30 patients with AFL demonstrated activation around counterclockwise direction (left anterior oblique projection). Double potentials were...
Background —The CD14 receptor of monocytes is an important mediator for the activation monocytes/macrophages by endotoxins from envelope Gram-negative bacteria (lipopolysaccharides). We identified a polymorphism in and examined whether this genetic marker influenced expression on affected predisposition to myocardial infarction. Methods Results —We C(−260)→T nucleotide change, creating Hae III promoter gene. The was determined 178 male patients <65 years old (cases; average age, 55.9±6.3...
Background— Electrode cooling by circulating fluid within the electrode (closed loop) or open irrigation facilitates radiofrequency (RF) ablation. This study compared lesion parameters between closed loop and with use of a canine model. Methods Results— In 8 anesthetized dogs, skin over thigh muscle was incised raised, forming cradle superfused heparinized blood (activated clotting time >350 seconds) at 37°C. A 7F 4-mm (irrigation 36 mL/min) 7.5F 3.5-mm 17 were positioned perpendicular to...
Background —The purpose of this study was to determine whether the coronary sinus (CS) musculature has electrical connections right atrium (RA) and left (LA) forms an RA-LA connection. Methods Results —Six excised dog hearts were perfused in a Langendorff preparation. A 20-electrode catheter (2-4-2-mm spacing center center) placed along CS. Excision pulmonary veins provided access LA, second LA endocardium opposite CS catheter. An incision opened longitudinally, microelectrodes inserted into...
Clinical efficacy has driven the use of larger electrodes (7F, length > or =4 mm) for radiofrequency ablation, which reduces electrogram resolution and causes variability in tissue contact depending on electrode orientation. With active cooling, ablation size may be reduced. The purpose this study was to examine effect temperature lesion with saline irrigation used cooling.In 11 anesthetized dogs, thigh muscle exposed bathed heparinized canine blood. A 7F catheter a 2- 5-mm irrigated tip...
Introduction: A canine model was used to compare cryoablation and radiofrequency ablation (RFA) within the coronary sinus (CS) in ability create a transmural CS myocardial (Trans‐CSM) lesion risk of artery stenosis. Methods: After left circumflex (LCx) angiography, an intravascular ultrasound (IVUS) probe placed LCx 29 dogs. An irrigated RFA catheter (8 dogs) or N 2 O (21 inserted into positioned mm LCx, confirmed by IVUS. RF (30–50W) applied for 60 seconds at 10 sites. Cryoablation (−75°C)...
The interaction between dietary fat, type and amount, the antioxidant butylated hydroxytoluene (BHT) on tumor induction growth by 7,12-dimethyl-benz[a]anthracene was studied. study to determine whether ingestion of polyunsaturated fat decreased or antagonized inhibitory action in comparison diets that either contained equivalent amounts a saturated were very low fat. rationale based known increased requirement for caused elevated levels unsaturated Because feeding excess without an adequate...
Increase in RF Lesion Depth with Larger Electrode. Introduction : Increasing electrode size allows an increase radiofrequency lesion depth. The purpose of this study was to examine the roles added cooling and electrode‐tissue interface area producing deeper lesions. Methods Results In 10 dogs, thigh muscle exposed superfused heparinized blood. An 8‐French catheter 4‐ or 8‐mm tip positioned against a blood flow 350 mL/min directed around electrode. Radiofrequency current delivered using four...
Computed tomography (CT) of the adrenal glands was performed on seven patients who had histologically proved disseminated histoplasmosis. All showed some degree gland abnormality. The range CT findings included minimal enlargement with faint flecks calcium, moderate focal low attenuation nodules, and massive large areas necrosis or dense calcification. changes in each patient were bilateral symmetrical. Adrenal shape usually preserved. Findings percutaneous biopsy, which under guidance, made...
Hypertension is a major cardiovascular risk factor possibly explaining the excessive morbidity and mortality in postmenopausal women. Cross-sectional longitudinal studies have explored this issue with diverging results. Our study sought to elucidate impact of menopause on blood pressure representative population sample.The involved randomly selected 908 female residents Prague district, aged 45-54 years (respondence rate, 63.9%). Three definitions were used: self-reported menstrual...
The sebaceous proliferations seen in patients with Muir-Torre syndrome are unique and difficult to classify. Having reviewed over 50 skin biopsies from five syndrome, we conclude that the primary proliferation involves hair follicle most often resembles either a keratoacanthoma or proliferation, but may have histologic features of both lesions. Unusual patterns components include solid basaloid sheets, mucinous areas, convoluted glands.
BackgroundData on the clinical significance of iron deficiency (ID) in patients with myocardial infarction (MI) are conflicting. This may be related to use various ID criteria.We aimed compare association different criteria all-cause mortality after MI.MethodsConsecutive hospitalized for their first MI at a large tertiary heart center were included. We evaluated metabolism parameters measured day hospital admission mortality.ResultsFrom 1,156 included (aged 64±12 years, 25 % women), 194...
The authors hypothesized that during RF ablation, the electrode to tissue interface temperature may significantly exceed in presence of cooling blood flow and produce thrombus. In 12 anesthetized dogs, skin over thigh muscle was incised raised form a cradle superfused with heparinized canine (ACT > 350 s) at 37°C. A 7 Fr, 4‐mm or 8‐mm ablation containing thermocouple held perpendicular 10‐g contact weight. Interface measured opposite sides using tiny optical probes. applications (n = 157)...