A5082950406- Physics and Engineering Research Articles
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Flexible and Reconfigurable Manufacturing Systems
- Hydraulic and Pneumatic Systems
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- German Literature and Culture Studies
- AI in cancer detection
- Engineering and Materials Science Studies
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Linguistic research and analysis
- Electric and Hybrid Vehicle Technologies
- Radiology practices and education
- Adrenal and Paraganglionic Tumors
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Oral health in cancer treatment
Paracelsus Medical University
2013-2024
Unfallkrankenhaus Salzburg
2003-2020
University of Salzburg
2009-2015
Paracelsus Medizinische Privatuniversität
2009
Salzburger Landeskliniken
2003-2006
St. John's University
2003
University of Stuttgart
1969-1973
Stuttgart University of Applied Sciences
1955-1969
Despite durable responses from immune-checkpoint blockade (ICB) in a subset of patients with advanced non-small cell lung cancer (NSCLC), the majority do not derive benefit this treatment. In analysis we evaluated impact concomitant administration antibiotics during initiation ICB on clinical outcome.Advanced non-squamous NSCLC receiving as second- or later line between 2015 and 2017 at our tertiary center Salzburg (Austria) were included. Concomitant use was defined within time frame one...
Immune-checkpoint blockade in front-line or second-line treatment improves survival advanced non-small cell lung cancer (aNSCLC) when compared with chemotherapy alone. However, easily applicable predictive parameters are necessary to guide immune-checkpoint inhibition clinical practice. In this retrospective bi-centric analysis, we investigated the impact of baseline patient and tumor characteristics on outcome aNSCLC patients treated programmed death protein 1(PD-1)/programmed ligand 1...
ALK FISH analysis is used as the reference standard to demonstrate rearrangements, which qualify patients with pulmonary adenocarcinomas for therapy inhibitors. The aim of this study was find screening antibody clones best positive and negative percentage agreement FISH.Three hundred three were evaluated stained five (5A4; D5F3; ALK1; ALK01; SP8) standardized detection systems. D5F3 additionally assessed using OptiView enhanced amplification system. found 14 cases (4.6%) that harboured...
Gliomas are the most common intrinsic brain tumors in adults, and accordance with their clinical behavior patients' outcome, they graded by World Health Organization (WHO) classification of tumors. One very interesting candidate for targeted tumor therapy may be epidermal growth factor receptor (EGFR) amplification. Here, we performed an integrated comparative analysis EGFR amplification 34 glioma samples using standard fluorescence situ hybridization (FISH) Illumina EPIC Infinium...
Abstract Purpose: Chemotherapy can be an integral component of the adjuvant management strategy for women with early stage breast cancer. To date, no tool is available to predict or monitor efficacy these therapies. The aim this proof-of-principle study was assess whether NEUROD1 DNA methylation able response neoadjuvant and chemotherapy. Experimental Design: Recently, we showed that differentially methylated in neoplastic versus nonneoplastic tissue samples. In study, used MethyLight...
OBJECTIVES To compare the efficiency of different transrectal ultrasonography (TRUS)‐guided prostate biopsy techniques for detecting cancer. MATERIALS AND METHODS In all, 81 prostates from radical prostatectomy were used and two consecutive sets sextant biopsies one 10‐core taken in each specimen. The consisted a four cores far lateral areas prostate. simulate procedure, all under TRUS guidance. RESULTS first set 44 cancers (54%) detected second 51 (63%). Combining both 57 (70%) carcinomas...
Effective systemic therapy for advanced pseudomyxoma peritonei (PMP) is the focus of investigation. We describe a case PMP arising from an adenoma appendix in 58-year-old man. First, patient underwent explorative laparotomy with ileocoecal resection, but without possibility major tumor debulking due to adhesive gross masses. Subsequently, six cycles Folfox IV chemotherapy were administered, response, severe side effects. Upon progressive disease, combination bevacizumab and capecitabine led...
Abstract Purpose Gliomas are the most frequent primary brain tumors of adults. Despite intensive research, there still no targeted therapies available. Here, we performed an integrated analysis glioma and programmed cell death ligand 1 (PD-L1) in 90 samples including 58 32 control tissues. Methods To identify PD-L1 expression glioma, immunohistochemical tumor proportion score (TPS) using clinically valid 22C3 antibody on controls WHO grade I–IV gliomas. Results We found that is highly...
Between 2002 and 2005, we made 343 intraoperative frozen section diagnoses with a telepathology system, which connected neurosurgical department to our of pathology. An expert neuropathologist performed at least one brief gross examination, this was followed by smear preparation slide for each case. Frozen diagnosis lasted on average 26.1 min, calculated from the beginning examination until surgeon given diagnosis. The majority cases (283 or 83%) were diagnosed in 15-40 min. mean time needed...
Evidence on PD-1/PD-L1-directed immune checkpoint inhibitor (ICI) therapy for advanced non-small-cell lung cancer (NSCLC) is mainly based clinical trials in first- or second-line settings.We aimed to investigate response and prognostic factors with special regard third- later-line therapy.We retrospectively analyzed all patients who had received ICI monotherapy nivolumab, pembrolizumab, atezolizumab NSCLC. Computed tomography evaluations were using evaluation criteria solid tumors (RECIST,...
Induction chemotherapy incorporating docetaxel, cisplatin and 5- fluorouracil before radiotherapy may improve the outcome of patients with advanced head neck cancer. Nevertheless, addition docetaxel increases hematological toxicity infectious complications. Therefore, genetic markers predicting efficacy this treatment regimen help to identify patients, who would have most benefit from intensive treatment. A cohort 78 cancer treated induction was assessed for clinical during curative...
<i>Objectives:</i> The aim of the study was to compare prostate biopsy outcome by using either standard or extended cutting length needles. <i>Material and Methods:</i> A total 74 consecutive prostates from radical prostatectomy were used. Two sextant biopsies performed ex vivo. We developed a precise simulation transrectal procedure ultrasound for guiding needle. In first set an 18-gauge tru cut needle with 19 mm length, powered automatic gun second single use...
No AccessJournal of UrologyAdult urology1 Mar 2006Novel Approach Human Epidermal Growth Factor Receptor 2 Detection in Noninvasive and Invasive Transitional Cell Carcinoma the Bladderis accompanied byGene Expression Profiling ERBB Receptors Ligands Bladder C. Hauser-Kronberger, K. Peham, J. Grall, W. Rausch, G. Hutarew, O. Dietze Hauser-KronbergerC. Hauser-Kronberger Department Pathology, General Hospital Paracelsus University Salzburg , PehamK. Peham Molecular Biology, Salzburg, GrallJ....
Endobronchial lipomas are rare benign tumors; less than 150 cases have been reported so far. Bronchial occlusion usually leads to a misdiagnosis of asthma/COPD or malignancy. We report the case 67-year-old man with history heavy smoking (100 pack years), dyspnea on exertion, cough, and malaise who was treated for pneumonia three weeks. Due nonresolving atelectasis superior segment right lower lobe, malignant endobronchial tumor suspected. Rigid bronchoscopy cryorecanalization led both...
We evaluated a dynamic telepathology system in routine use after two-year developmental phase. In two three-month studies, years apart, all intraoperative frozen sections were examined by one pathologist via the system. Laboratory technicians sampled tissues at gross examination and connected with videoconference. Specimens immediately reviewed diagnosis same diagnostician. second study there 342 cases. The mean time required to diagnose small specimens such as biopsies was 8 min (range...
A 79-year-old woman was admitted complaining of progressive weakness and numbness the right hand. The patient otherwise healthy. patient's history unremarkable. Clinical electrophysiological examination revealed a compression ulnar nerve in sulcus Guyon's canal. Ultrasound evaluation showed suspicious tumour proximal to elbow close nerve. then released an epineural perineural lesion 3-4 cm excised under microscope. histopathology confirmed as non-caseating sarcoid granulomas. no other signs...