A5062967586- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Radiomics and Machine Learning in Medical Imaging
- Pharmacological Effects and Toxicity Studies
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Cervical and Thoracic Myelopathy
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Spinal Hematomas and Complications
- Drug Transport and Resistance Mechanisms
- Meningioma and schwannoma management
- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Inflammatory mediators and NSAID effects
- Memory and Neural Mechanisms
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Nanoparticle-Based Drug Delivery
- Scoliosis diagnosis and treatment
- Brain Metastases and Treatment
Johannes Kepler University of Linz
2021-2025
Clinical Research Institute
2025
Kepler Universitätsklinikum
2017-2024
Medical University of Vienna
2012-2024
Klinik Hietzing
2019
Universität Ulm
2019
Comprehensive Cancer Center Vienna
2013-2017
University Hospital Heidelberg
2017
German Cancer Research Center
2017
Heidelberg University
2017
OBJECTIVE The authors' group recently published a novel technique for navigation-guided frameless stereotactic approach the placement of depth electrodes in epilepsy patients. To improve accuracy trajectory and enhance procedural workflow, authors implemented iSys1 miniature robotic device present study into this routine. METHODS As first step, preclinical phantom was performed using human skull model, timing between 5 implanted with manual aid robot were compared. After showed an increased...
Wnt activation in medulloblastomas is associated with good outcome. Upfront testing and risk-adapted stratification of patients will be done future clinical studies. In a cohort 186 paediatric our aim was to identify the optimal methods standard practice detect this subgroup.Nuclear accumulation β-catenin analysed by immunohistochemistry (IHC). DNA FFPE tissue amplified PCR for single-strand conformation polymorphism analysis direct sequencing CTNNB1 exon 3. Copy number chromosome 6...
Abstract GABAergic neurotransmission in the amygdala contributes to regulation of emotional processes anxiety, stress, reward, mnestic functions, addiction, and epilepsy. Species‐specific differences distribution composition GABA A receptors may account for distinct effects side‐effects agents. However, data on human are lacking. Here, expression receptor subunits α1, α2, α3, α5, β2, β2/3, γ2 was studied using immunohistochemistry. Hippocampi were evaluated as a reference structure. Neuronal...
Abstract Low-grade gliomas are infiltrative brain tumors that can lead to significant neurological deficits due their invasive nature. The prevailing belief is low-grade primarily disseminate along white matter tracts, but quantitative in vivo evidence supporting this concept lacking. Clarifying true growth patterns essential for optimizing therapeutic strategies. We conducted a analysis of tumor longitudinal cohort 43 untreated patients with unigyral World Health Organization grade 2 or 3...
Ependymomas account for up to 10% of childhood CNS tumors and have a high rate tumor recurrence despite gross total resection. Recently, classification into molecular ependymoma subgroups has been established, but the mechanisms underlying aggressiveness certain subtypes remain widely enigmatic. The aim this study was dissect clinical biological role telomerase reactivation, frequent mechanism cancer cells evade cellular senescence, in pediatric ependymoma.We determined enzymatic activity,...
Temporal lobe epilepsy (TLE) is the most frequent form of focal in adults. Because approximately half these patients develop drug resistance, surgery designed to remove epileptogenic zone an excellent option selected patients. Histopathological analyses hippocampal specimens TLE revealed 4 types Ammon's horn sclerosis, which are correlated with long-term epileptological outcome. The aim this study was correlation noninvasive, high-resolution, morphological magnetic resonance imaging (MRI) at...
Temporal lobe epilepsy (TLE) is characterized by distinct neuropathological findings, such as hippocampal sclerosis and reactive astrogliosis. Recently, MRI studies have revealed the presence of white matter pathology in brains patients. The purpose this study to evaluate involvement oligodendroglia epileptogenic process. Using TPPP/p25 a marker for mature oligodendroglia, we evaluated hippocampus 26 surgical specimens from patients with TLE 9 autopsy controls without alterations changes...
For stereotactic implantation of depth electrodes in refractory epilepsy, both frame-based and frameless techniques have been developed. The higher versatility current compared with framed-based methods is paid by the need a standard burr hole for 1 electrode.To develop method that allows convenient electrode via percutaneous bolt as used methods, thereby avoiding hole.We adopted our technique from biopsy designed GIDE, bone-fixated Guide Implantation Depth Electrodes. This reducing sleeve...
A large number of potential tissue biomarkers has been proposed for brain tumors.However, hardly any have adopted routine clinical use, so far.For most candidate substantial controversy exists with regard to their usefulness in practice.The multidisciplinary neurooncology taskforce the Vienna Comprehensive Cancer Center Central Nervous System Unit (CCC-CNS) addressed this issue and elaborated a four-tiered levels-of-evidence system assessing analytical performance (reliability test result)...
OBJECTIVE The aim of this study was to present long-term seizure outcome data in a consecutive series patients with refractory mesial temporal lobe epilepsy primarily treated transsylvian selective amygdalohippocampectomy (SAHE). METHODS authors retrospectively analyzed prospectively collected for all who had undergone resective surgery medically at their institution between July 1994 and December 2014. Seizure assessed according the International League Against Epilepsy (ILAE) Engel...
Abstract Machine learning (ML) has revolutionized data processing in recent years. This study presents the results of first prediction models based on a long-term monocentric registry patients with microsurgically treated unruptured intracranial aneurysms (UIAs) using temporal train-test split. Temporal splits allow to simulate prospective validation, and therefore provide more accurate estimations model’s predictive quality when applied future patients. ML for Glasgow outcome scale,...
BACKGROUND AND OBJECTIVES: Chronic subdural hematoma (CSDH) is commonly managed through burr hole surgery. Routine follow-up using computed tomography (CT) imaging frequently used at many institutions, contributing to significant radiation exposure. This study evaluates the feasibility, safety, and reliability of trans-burr sonography as an alternative postoperative modality, aiming reduce exposure by decreasing frequency CT scans. METHODS: We conducted a prospective pilot on 20 patients who...
To assess the impact of individual surgeon experience on overall survival (OS), extent resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.GBM aged ≥ 65 years who underwent tumor at two academic centers were analyzed. The each neurosurgeon was quantified three ways: (1) total number previously glioma surgeries (lifetime experience); (2) previous five (medium-term experience) (3) last (short-term...
Determining the optimal course of treatment for low grade glioma (LGG) patients is challenging and frequently reliant on subjective judgment limited scientific evidence. Our objective was to develop a comprehensive deep learning assisted radiomics model assessing not only overall survival in LGG, but also likelihood future malignancy growth velocity. Thus, we retrospectively included 349 LGG prediction using clinical, anatomical, preoperative MRI data. Before performing analysis, U2-model...
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. Post-hemorrhagic vasospasm neurological deterioration a major concern in this context. NicaPlant®, modified release formulation of the calcium channel blocker nicardipine, has shown vasodilator efficacy preclinically similar known as NPRI anti-vasospasm activity aSAH patients under compassionate use. The study aimed to assess pharmacokinetics pharmacodynamics NicaPlant® pellets prevent after clip...
To review the surgical results and to identify possible parameters influencing clinical outcomes in an unselected patient collective undergoing minimally invasive lumbar interbody fusion a spinal care unit.A total of 229 adult patients who underwent between 2008 2016 were included this retrospective analysis. Lumbar was performed using transforaminal (TLIF) devices posterolateral fusion. eliminate confounding parameters, all indicated by degenerative pathologies, surgery same device....
The congenital disorder of glycosylation characterized by a deficiency phosphomannomutase 2 (PMM2-CDG) is the most common variant disorders glycosylation. Besides typical clinical features, such as dysmorphism and abnormal body fat distribution, coagulation abnormities often lead to thromboembolic hemorrhagic events in these patients. However, only cases intracerebral bleeding patients with PMM2-CDG have been described so far. A 4-year-old girl who initially presented symptoms resulting from...
An optimal fixative should ideally combine the advantages of formalin fixation and freezing, allowing for good preservation histology molecular components, easy handling storage, lack toxicity, low costs. Most these criteria are fulfilled by ethanol-based solutions, due to our experience with commercial RCL2 fixative, reflected published single-center trial, we initiated a multicenter ring trial. However, during its course, was discontinued on market. Therefore, created own agent, KINFix,...
OBJECTIVE In this study, the authors investigated underlying mechanisms responsible for high tumor recurrence rates of adamantinomatous craniopharyngioma (ACP) after radiotherapy and developed new targeted treatment protocols to minimize recurrence. ACPs are characterized by activation receptor tyrosine kinase epidermal growth factor (EGFR), known mediate radioresistance in various entities. The impact inhibitors (TKIs) gefitinib or CUDC-101 on radiation-induced cell death associated...
OBJECTIVE Contemporary oncological paradigms for adjuvant treatment of low- and intermediate-grade gliomas are often guided by a limited array parameters, overlooking the dynamic nature disease. The authors’ aim was to develop comprehensive multivariate glioma growth model based on multicentric data, facilitate more individualized therapeutic strategies. METHODS Random slope models with subject-specific random intercepts were fitted retrospective cohort grade II III from database at Kepler...