A5101446221- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- NMR spectroscopy and applications
- Liver Disease and Transplantation
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Photoacoustic and Ultrasonic Imaging
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- HIV Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- HIV-related health complications and treatments
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Bipolar Disorder and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical Imaging Techniques and Applications
- Cytomegalovirus and herpesvirus research
University of California, Los Angeles
2016-2025
Bioengineering Center
2023
Sinai Hospital
2022
VA Greater Los Angeles Healthcare System
2015-2020
Northwestern University
2017-2020
Laboratoire Animal et Agroécosystèmes
2016-2017
Université de Lorraine
2017
Tufts University
2016
Johns Hopkins University
2015
Kaiser Permanente
2015
It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves and spread to the central nervous system (CNS), leading Parkinson disease related disorders. Although recent data suggest αS pathology can within mouse brain, there is no direct evidence for of from a site. In present study, we show hind limb intramuscular (IM) injection induce CNS human Ala53Thr (M83) wild-type (M20) transgenic (Tg) models. Within 2-3 mo after IM homozygous M83 Tg mice 3-4 hemizygous...
Abstract A two‐dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°–180°–90°) is proposed for whole‐body spectroscopy (MRS). Using the product operator formalism, theoretical calculation of as well coherence transfer efficiencies in 2D MRS presented. Phantom model solutions were used to test and optimize efficiency sequence. combination different MRI transmit/receive RF coils was used: head coil 3″ surface...
To determine whether findings at preoperative endorectal coil magnetic resonance (MR) imaging influence the decision to preserve neurovascular bundles and extent of surgical margins in robotic-assisted laparoscopic prostatectomy (RALP).This study was approved by investigational review board compliant with HIPAA; requirement obtain informed consent waived. The authors prospectively evaluated 104 consecutive men biopsy-proved prostate cancer who underwent MR subsequent RALP. performed 1.5 T...
Intracerebral injection of amyloidogenic α-synuclein (αS) has been shown to induce αS pathology in the CNS nontransgenic mice and transgenic mice, albeit with varying efficiencies. In this study, using wild-type human (line M20), we demonstrate that intracerebral recombinant or soluble induces extensive intracellular inclusion is associated robust gliosis. Near site, a significant portion inclusions are detected neurons but also astrocytes microglia. Aberrant induction expression...
OBJECTIVE: The diagnosis of bipolar disorder in juveniles is controversial. This study was designed to compare proton magnetic resonance spectroscopy (1H MRS) patients with or intermittent explosive disorder, two groups symptomatic overlap but categorical distinction. Children designate whose illness clinically resembles pediatric does not satisfy DSM-IV criteria for mania. Based on the authors' previous report higher levels 1H MRS cingulate myo-inositol/creatine youngsters than normal...
Abstract Background α-Synuclein (αS) is the major component of several types brain inclusions including Lewy bodies, a hallmark Parkinson’s disease. Aberrant aggregation αS also associated with cellular demise in multiple neurologic disorders collectively referred to as synucleinopathies. Recent studies demonstrate induction pathology by single intracerebral injection exogenous amyloidogenic adult non-transgenic and transgenic mice expressing human αS. To further investigate mechanism...
Introduction Obstructive sleep apnea (OSA) affects approximately 10% of adults, and alters brain gray white matter. Psychological physiological symptoms the disorder are sex-specific, perhaps related to greater injury occurs in female than male patients Our objective was identify influences OSA separated by sex on cortical Methods We assessed thickness 48 mild-severe (mean age±std[range] = 46.5±9.0[30.8–62.7] years; apnea-hypopnea index 32.6±21.1[6–102] events/hour; 12 female, 36 male;...
Obstructive sleep apnea (OSA) patients show hippocampal-related autonomic and neurological symptoms, including impaired memory depression, which differ by sex, are mediated in distinct hippocampal subfields. Determining sites extent of sub-regional injury OSA could reveal localized structural damage linked with symptoms. High-resolution T1-weighted images were collected from 66 newly-diagnosed, untreated (mean age ± SD: 46.3 8.8 years; mean AHI 34.1 21.5 events/h;50 male) 59 healthy...
The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) prostate cancer (PCa) patients with three classes pathological Gleason scores (GS). Patients whose GS met these criteria (GS , and ) were included in this study. DWI performed using values 0, 50, 400 s/mm2 44 an endorectal coil on a 1.5T MRI scanner. calculated data different scores. In high-grade score (), ADC lower peripheral gland tissue, pathologically determined...
Despite the success of antiretroviral therapy (ART), perinatally infected HIV remains a major health problem worldwide. Although advance neuroimaging studies have investigated structural brain changes in HIV-infected adults, regional gray matter (GM) and white (WM) volume not been reported adolescents young adults. In this cross-sectional study, we GM WM 16 youths receiving ART (age 17.0 ± 2.9 years) compared with age-matched 14 healthy controls 16.3 2.3 using magnetic resonance imaging...
Genetic studies have established a causative role for α-synuclein (αS) in Parkinson's disease (PD), and the presence of αS aggregates form Lewy body (LB) neurite (LN) protein inclusions are defining pathological features PD. Recent data has that extracellular can induce intracellular pathologies supporting hypothesis pathology spread via "prion-like" self-templating mechanism.Here we investigated potential conformational templating by seeding using recombinant wild-type PD-linked mutant...
This study examined neurologic abnormalities (as measured by proton magnetic resonance spectroscopy imaging and diffusion tensor imaging), neurocognitive performance, fatigue among a sample of adults with hepatitis C virus (HCV). We hypothesized that HCV+ individuals would demonstrate structural brain compromise consistent frontostriatal dysfunction as well increased compared to controls.Participants were 76 diagnosed HCV 20 controls who underwent comprehensive evaluation clinical...
Background/Objectives: This study evaluated metabolites and lipid composition in the calf muscles of Type 2 diabetes mellitus (T2DM) patients age-matched healthy controls using multi-dimensional MR spectroscopic imaging. We also explored association between muscle metabolites, lipids, intra-abdominal fat T2DM. Methods: Participants included 12 T2DM (60.3 ± 8.6 years), 9 (AMHC) (60.9 7.8 10 young (YHC) (28.3 1.8 years). acquired 2D spectra an enhanced accelerated 5D echo-planar correlated...
Introduction: Cerebral blood flow (CBF) is a major determinant of when and where within the brain stroke occurs. The brain’s demand for oxygen nutrients makes it sensitive to pulsatility propagating from heart. contribution cardiac CBF poorly understood. We present pilot study using 4D MRI sequentially measure both aortic in same individual our initial findings comparing pressure (BP), flow, healthy volunteers. Methods: acquired single session Siemens 3T Magnetom Vida scanner 5 volunteers (4...