A5023026845- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Lipid Membrane Structure and Behavior
- Axon Guidance and Neuronal Signaling
- Radiation Therapy and Dosimetry
- Environmental Policies and Emissions
- Engineering Applied Research
- Venous Thromboembolism Diagnosis and Management
- Engineering and Material Science Research
- Global Cancer Incidence and Screening
- Angiogenesis and VEGF in Cancer
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Receptor Mechanisms and Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urologic and reproductive health conditions
- Cellular transport and secretion
- Transportation Safety and Impact Analysis
- Advanced Fluorescence Microscopy Techniques
- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Advances in Oncology and Radiotherapy
- Hormonal and reproductive studies
- HER2/EGFR in Cancer Research
National Institute of Neurological Disorders and Stroke
2020-2025
National Institutes of Health
2020-2024
Stoke Mandeville Hospital
2023
Alaska Heart and Vascular Institute
2023
Johns Hopkins University
2014-2021
Janelia Research Campus
2018-2021
Howard Hughes Medical Institute
2020-2021
Palmetto General Hospital
2021
University of California, Los Angeles
2011-2020
St George's Hospital
2020
<h3>Importance</h3> The optimal treatment for Gleason score 9-10 prostate cancer is unknown. <h3>Objective</h3> To compare clinical outcomes of patients with after definitive treatment. <h3>Design, Setting, and Participants</h3> Retrospective cohort study in 12 tertiary centers (11 the United States, 1 Norway), 1809 treated between 2000 2013. <h3>Exposures</h3> Radical prostatectomy (RP), external beam radiotherapy (EBRT) androgen deprivation therapy, or EBRT plus brachytherapy boost...
The endoplasmic reticulum (ER) is the site of synthesis secretory and membrane proteins contacts every organelle cell, exchanging lipids metabolites in a highly regulated manner. How ER spatially segregates its numerous diverse functions, including positioning nanoscopic contact sites with other organelles, unclear. We demonstrate that hypotonic swelling cells converts membrane-bound organelles into micrometer-scale large intracellular vesicles (LICVs) retain luminal protein content maintain...
Hypofractionated, stereotactic body radiotherapy (SBRT) is an emerging treatment approach for prostate cancer. We present the outcomes low-risk cancer patients with a median follow-up of 5 years after SBRT. Between Dec. 2003 and 2005, pooled cohort 41 consecutive from Stanford, CA Naples, FL received SBRT CyberKnife clinically localized, Prescribed dose was 35-36.25 Gy in five fractions. No patient hormone therapy. Kaplan-Meier biochemical progression-free survival (defined using Phoenix...
To evaluate the early and late health-related quality of life (QOL) outcomes among prostate cancer patients following stereotactic body radiation therapy (SBRT).Patient self-reported QOL was prospectively measured 864 from phase 2 clinical trials SBRT for localized cancer. Data Expanded Prostate Cancer Index Composite (EPIC) instrument were obtained at baseline regular intervals up to 6 years. delivered a median dose 36.25 Gy in 4 or 5 fractions. A short course androgen deprivation given 14%...
Here we introduce the fully quantified spectral imaging (FSI) method as a new tool to probe stoichiometry and stability of protein complexes in biological membranes. The FSI yields two dimensional membrane concentrations FRET efficiencies native plasma It can be used characterize association proteins: differentiate between monomers, dimers, or oligomers, produce binding (association) curves, measure free energies membrane. We use study lateral interactions Vascular Endothelial Growth Factor...
The EphA2 receptor tyrosine kinase is capable of activating multiple diverse signaling pathways with roles in processes such as tissue homeostasis and cancer. known to form activated oligomers the presence ephrin-A ligands. Here, we characterize lateral interactions between full-length molecules plasma membrane three types ligands (dimeric ephrinA1-Fc, monomeric ephrinA1, an engineered peptide ligand) well absence ligand, using a quantitative FRET technique. data show that forms higher-order...
There is a clear dose response for localized prostate cancer radiotherapy and there probably radiobiological rationale hypo-fractionation. Combining the two should maximize tumor control increase therapeutic ratio. This study examines technical feasibility of CyberKnife (a robotic arm-driven linear accelerator) cancer. Its ability to deliver non-coplanar non-isocentric arcs can yield maximally conformal isodoses. It only integrated system capable target position verification real-time...
To facilitate the use of biological outcome modeling for treatment planning, an exponential function is introduced as a simpler equivalent to Lyman formula calculating normal tissue complication probability (NTCP). The single parameter chosen reproduce calculation within approximately 0.3%, and thus enable easy conversion data contained in empirical fits parameters organs at risk (OARs). Organ new are given terms model m TD(50), conversely TD(50) expressed equation. role volume-effect n...
NIHR), was set up in 1993.It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage provide care NHS.'Health technologies' are broadly defined to include all interventions used promote health, prevent treat disease, improve rehabilitation long-term care, rather than settings care.The findings from HTA Programme directly influence decision-making bodies such as National Institute Health Clinical Excellence...
The predictive value of Gleason grading from prostate needle biopsy was examined and the patterns grade discordance with surgical specimens are discussed in terms their clinical implications. scores matched radical prostatectomy were compared 428 consecutive patients. Patterns concordance respect to numerical agreement as well whether differences result a change group assignment score 2–4, 5–6, 7, 8–10. coefficient agreement, kappa, accuracy used measure value. An exact match present 41%...
The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) prostate cancer (PCa) patients with three classes pathological Gleason scores (GS). Patients whose GS met these criteria (GS , and ) were included in this study. DWI performed using values 0, 50, 400 s/mm2 44 an endorectal coil on a 1.5T MRI scanner. calculated data different scores. In high-grade score (), ADC lower peripheral gland tissue, pathologically determined...
The erythropoietin-producing hepatocellular carcinoma A3 (EphA3) receptor tyrosine kinase (RTK) regulates morphogenesis during development and is overexpressed mutated in a variety of cancers. EphA3 activation believed to follow 'seeding mechanism' model, which ligand binding the monomeric acts as trigger for signal-productive clustering. We study lateral interactions on surface live cells we demonstrate that forms dimers absence binding. further show these are stabilized by involving...
Abstract Phase transitions of cellular proteins and lipids play a key role in governing the organisation coordination intracellular biology. Recent work has raised intriguing prospect that phase can be co-regulated. Here we investigate this possibility ribonucleoprotein (RNP) granule-ANXA11-lysosome ensemble, where ANXA11 tethers RNP granules to lysosomal membranes enable their co-trafficking. We show changes protein state within system, driven by low complexity N-terminus, induces coupled...
Abstract Cyclin dependent kinases 4 and 6 (CDK4 CDK6) cyclin kinase 2 (CDK2) act in a coordinated fashion to phosphorylate repress RB protein, effectively driving cell proliferation via E2F activation. Currently, CDK4/6 inhibitors combination with endocrine therapy are considered the standard of care for treatment hormone-receptor (HR)-positive/HER2-negative breast cancer, but unfortunately most patients metastatic disease ultimately progress. High CCNE1 expression is one underlying...