A5001887362- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Statistical Methods in Clinical Trials
- Renal cell carcinoma treatment
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Genetic Associations and Epidemiology
- Urological Disorders and Treatments
- Global Cancer Incidence and Screening
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Cancer Risks and Factors
- Urinary and Genital Oncology Studies
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Venous Thromboembolism Diagnosis and Management
- Testicular diseases and treatments
- Molecular Biology Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Health Systems, Economic Evaluations, Quality of Life
Kaiser Permanente
2020-2025
Kaiser Permanente San Francisco Medical Center
2023-2025
Kaiser Permanente Oakland Medical Center
2015-2023
Georgia Institute of Technology
2023
Mill Valley Public Library
2019
Veterans Health Administration
2007-2013
Stanford University
2004-2013
Stanford Medicine
2001-2013
Palo Alto Institute
2010-2013
Duke University
2007-2013
Major clinical issues in bladder cancer include the identification of prediction markers and novel therapeutic targets for invasive cancer. In current study, we describe isolation characterization a tumor-initiating cell (T-IC) subpopulation primary human cancer, based on expression similar to that normal basal cells (Lineage-CD44(+)CK5(+)CK20(-)). The T-IC was defined functionally by its enriched ability induce xenograft tumors vivo recapitulated heterogeneity original tumor. Further,...
We define the optimal systematic biopsy regimen to detect carcinoma of prostate.A total 483 consecutive patients referred for an abnormal digital rectal examination and/or prostate specific antigen (PSA) 4.0 ng./ml. or greater underwent transrectal ultrasound and biopsy. Lateral biopsies peripheral zone at base mid gland were added routine sextant a 10 zone. Patients with than 50 cc also transition in lobar parasagittal plane. Detection rates various regions assessed. Various schemes then...
Given the limited information regarding impact of obesity on treatment outcomes for prostate cancer, we sought to examine relationship between body mass index (BMI) and cancer control after radical prostatectomy (RP).
OBESITY INthe United States has dramatically increased in the past decade. 1Increased body mass index (BMI) been linked to death from colon, breast, and many other cancers. 2 Although there are biological bases for risk of certain cancers obese persons, 3 delayed diagnosis may provide an explanation advanced stage disease poor outcome.Obesity presents technical problems cancer detection, since adiposity hinder physical examination interfere with imaging ancillary tests. 4Likewise, obesity...
We compared hexaminolevulinate fluorescence cystoscopy with white light for detecting Ta and T1 papillary lesions in patients bladder cancer.A total of 311 known or suspected cancer underwent instillation 50 ml 8 mM HAL 1 hour. The was inspected using cystoscopy, followed by blue (fluorescence) cystoscopy. Papillary were mapped resected histological examination.Noninvasive pTa tumors found 108 196 evaluable (55.1%). In 31 (29%) at least more tumor detected than (p<0.05). Six these had no...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2003Extended Peripheral Zone Biopsy Schemes Increase Cancer Detection Rates and Minimize Variance in Prostate Specific Antigen Age Related Rates: Results a Community Multi-Practice Study JOSEPH C. PRESTI, GERARD J. O’DOWD, M. CRAIG MILLER, RUBINA MATTU, ROBERT W. VELTRI PRESTIJOSEPH PRESTI More articles by this author , O’DOWDGERARD O’DOWD MILLERM. MILLER MATTURUBINA MATTU VELTRIROBERT View All Author...
The morphologic distinction between prostate and urothelial carcinoma can be difficult. To identify novel diagnostic markers that may aid in the differential diagnosis of versus carcinoma, we analyzed expression patterns bladder cancer tissues using complementary DNA microarrays. Together with our prior studies on renal neoplasms normal kidney, these suggested gene for placental S100 (S100P) is specifically expressed benign malignant cells. Using tissue microarrays, a polyclonal antiserum...
No AccessJournal of UrologyClinical Urology: Original Articles1 Dec 1998PROSPECTIVE EVALUATION OF LATERAL BIOPSIES THE PERIPHERAL ZONE FOR PROSTATE CANCER DETECTION JAMES J. CHANG, KATSUTO SHINOHARA, VIVEK BHARGAVA, and JOSEPH C. JR. PRESTI CHANGJAMES CHANG , SHINOHARAKATSUTO SHINOHARA BHARGAVAVIVEK BHARGAVA PRESTIJOSEPH View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62254-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
Obesity has been associated with lower serum testosterone, theoretically resulting in decreased PSA production. also prostatic enlargement, making the detection of existent cancer more difficult. Together these findings would result an apparent protective effect obesity on prostate risk due to technical issues unrelated biology. We examined association between BMI, and weight a cohort men undergoing RP.We evaluated BMI using linear regression, adjusting for patient age at RP, year race,...
A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic white, 4.9% African-American, 7.0% East Asian, and 7.8% Latino) revealed a new independent risk indel rs4646284 at the previously identified locus 6q25.3 that replicated PEGASUS (N = 7,539) Multiethnic Cohort 4,679) with an overall P 1.0 × 10(-19) (OR, 1.18). Across locus, exhibited strongest expression SLC22A1 (P 1.3 10(-23)) SLC22A3 3.2...
Purpose Previous studies suggest that some common medications alter prostate-specific antigen (PSA) levels. It remains unclear whether these reported medication effects are due to clinicodemographic factors or concurrent use of other medications. We investigated the impact individual and combinations on PSA in a large cross-sectional study United States population. Patients Methods The included men ≥ 40 years old without prostate cancer from 2003 2004 2005 2006 cycles National Health...