A5080392003- Amyotrophic Lateral Sclerosis Research
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Myasthenia Gravis and Thymoma
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Peripheral Nerve Disorders
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Neurological diseases and metabolism
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Multiple Sclerosis Research Studies
- Ion channel regulation and function
- Antifungal resistance and susceptibility
- Sarcoidosis and Beryllium Toxicity Research
- Neurology and Historical Studies
- Myofascial pain diagnosis and treatment
- Prion Diseases and Protein Misfolding
- Action Observation and Synchronization
- Neuroscience and Neural Engineering
Kyoto Prefectural University of Medicine
2015-2024
North Medical Center
2021
The University of Sydney
2016-2019
Royal Prince Alfred Hospital
2018
Kyoto College of Medical Science
2016
Chiba University
2009-2013
Juntendo University
2012
Chiba University Hospital
2009
To study the utility of muscle ultrasound (US) for detection fasciculations and its contribution to diagnosis in amyotrophic lateral sclerosis (ALS). Fasciculations are characteristic features ALS, US can detect them easily reliably. New diagnostic criteria Awaji algorithm, reintroduced as evidence acute denervation equivalent that fibrillations positive sharp waves.In 81 consecutive patients with sporadic we prospectively performed needle EMG 6 muscles (tongue, biceps brachii, first...
To systematically study abnormalities in cytokine profiles polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, which has been increasingly recognized as a cause of demyelinating neuropathy associated with plasma cell dyscrasia elevated serum level vascular endothelial growth factor (VEGF).In this case-control study, we measured levels 27 cytokines patients POEMS syndrome using multiplex suspension array system, compared them those controls. In 10...
<h3>Objective</h3> To elucidate the ultrasound (US) features of peripheral nerves including nerve roots in patients with different types Charcot-Marie-Tooth disease (CMT), and association between US findings, clinical parameters conduction studies (NCS) CMT1A. <h3>Methods</h3> median, sural great auricular C6 root was performed CMT1A (n=20), <i>MPZ</i>-associated CMT (n=3), <i>NEFL</i>-associated (n=4), <i>EGR2</i>-associated (n=1), <i>ARHGEF10</i>-associated (n=1) controls (n=30). In CMT1A,...
<h3>Objective</h3> To investigate whether or not the lesions in sporadic amyotrophic lateral sclerosis (ALS) originate from a single focal onset site and spread contiguously by prion-like cell-to-cell propagation rostrocaudal direction along spinal cord, as has been hypothesised (the 'single seed simple propagation' hypothesis). <h3>Methods</h3> Subjects included 36 patients with ALS initial symptoms bulbar, respiratory upper limb regions. Abnormal spontaneous activities needle...
To assess the significance of distal compound muscle action potential (CMAP) duration for diagnosis demyelinating neuropathies, electrophysiologic data were reviewed from 471 subjects, including 145 normal controls, 60 patients with chronic inflammatory polyneuropathy (CIDP), 205 other neuropathy, and 61 amyotrophic lateral sclerosis (ALS). The distally evoked CMAP was measured in median, ulnar, tibial, peroneal nerves. Optimal cut-off values calculated receiver-operating characteristic...
In this study we aimed to clarify whether muscle ultrasound (US) of the forearm can be used differentiate between patients with sporadic inclusion body myositis (s-IBM) and those s-IBM-mimicking diseases.We compared echo intensity (EI) flexor digitorum profundus (FDP) carpi ulnaris (FCU) muscles in s-IBM (n = 6), polymyositis/dermatomyositis (PM/DM; n amyotrophic lateral sclerosis (ALS; 6).We identified EI abnormalities 100% s-IBM, 33% PM/DM, ALS. An "FDP-FCU echogenicity contrast," a US...
To determine the diagnostic and prognostic significance of neurofilament light chain (NfL), TAR DNA-binding protein 43 (TDP-43), total tau (t-tau) in cerebrospinal fluid (CSF) plasma patients with amyotrophic lateral sclerosis (ALS) to investigate whether combined use those biomarker candidates can improve their performance.This was a single-center, prospective, longitudinal study. CSF samples were collected at time enrollment from discovery cohort 29 ALS age-matched controls without...
ABSTRACT Introduction Sensorimotor neuropathy associated with IgG4 antibodies to neurofascin‐155 (NF155) was recently described. The clinical phenotype is typically young onset, distal weakness, and in some cases, tremor. Methods From a consecutive cohort of 55 patients diagnosed chronic inflammatory demyelinating polyneuropathy, screening for anti‐NF155 undertaken. Patients underwent assessment, diagnostic neurophysiology, including peripheral axonal excitability studies nerve ultrasound....
: This study aimed to reveal the diagnostic utility of Gold Coast (GC) criteria in Japanese patients with amyotrophic lateral sclerosis (ALS) by comparing sensitivity/specificity revised El Escorial (R-EE) and Awaji criteria, because its has not been studied Asian ALS.
This study seeks to elucidate the optimal scan time detect fasciculations by using ultrasound in diagnosis of amyotrophic lateral sclerosis (ALS).The intervals between were recorded from tongue, abdominal, and limb muscles ALS patients, incorporating assessment cumulative probability 2 occurring.From prospective studies 228 19 detectable 68% patients. The longest interfasciculation interval was 81.4 s hand muscle. occurring calculated as ≥0.9 all during a period 60 s.A definition or more...
ABSTRACT Introduction : This study explored potential diagnostic markers of nerve ultrasound in differentiating amyotrophic lateral sclerosis (ALS) from mimic disorders. Methods Ultrasound the median, ulnar, and tibial nerves was conducted 53 patients with ALS, 32 ALS‐mimic disorders, 30 controls. Nerve cross‐sectional area (CSA) distal–proximal ratios were calculated. Results The median CSA upper arm decreased (7.9 ± 1.3 mm 2 vs. 9.0 1.4 , P < 0.05), wrist–upper ratio increased ALS...
This chapter discusses comprehensive neurophysiological biomarkers utilised in motor neuron disease (MND) and, particular, its commonest form, amyotrophic lateral sclerosis (ALS). These encompass the conventional techniques including nerve conduction studies (NCS), needle and high-density surface electromyography (EMG) H-reflex as well novel techniques. In last two decades, new methods of assessing loss units a muscle have been developed, that are more convenient than earlier unit number...
Objective To study the utility of CT for detection small bone lesions in POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome. For patients with a solitary lesion, irradiation is first-line treatment, whereas systemic chemotherapy indicated multiple lesions. Therefore it important to correctly identify number Methods We studied sensitivity chest/abdomen/pelvic detect 28 99mTc-HMDP scintigraphy was performed 14 patients, results were compared CT. Results...
Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of 37-year-old woman who was diagnosed ADEM at 4 years old age and subsequently developed ON recurrent 33 after initial onset. A serum analysis showed anti-MOG antibody positivity. This only previously in pediatric cases. Neurologists thus need to be aware that may occur adult...
Objective To investigate the association between changes in anti-acetylcholine receptor antibody (AChR Ab) levels induced by immunosuppressive treatment and myasthenia gravis (MG) prognosis at 1-year post-treatment patients with MG. Methods We included 53 consecutive AChR Ab-positive MG whose Ab were remeasured within 100 days of initiating (median remeasuring time post-treatment: 71 (55–84) days). The level reduction rate (RR-AChRAb, %/day) adjusted for initiation, remeasurement was...