A5068249765- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Hereditary Neurological Disorders
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Retinoids in leukemia and cellular processes
- Autoimmune Bullous Skin Diseases
- CNS Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Histone Deacetylase Inhibitors Research
Chiba University Hospital
2015-2025
International University of Health and Welfare
2017-2025
Chiba University
2008-2021
Toho University Medical Center Sakura Hospital
2020
Toho University
2020
Mita Hospital
2018
Kyoto University Hospital
2014
Juntendo University
2012
Suzuki (Japan)
2008
Japanese Society for Dialysis Therapy
2007
Polycomb group (PcG) proteins are essential regulators of hematopoietic stem cells. Recent extensive mutation analyses the myeloid malignancies have revealed that inactivating somatic mutations in PcG genes such as EZH2 and ASXL1 occur frequently patients with myelodysplastic disorders including syndromes (MDSs) MDS/myeloproliferative neoplasm (MPN) overlap (MDS/MPN). In our patient cohort, were also found often coincided tet methylcytosine dioxygenase 2 (TET2) mutations. Consistent these...
CTLA-4 is expressed on the surface of activated T cells and negatively regulates cell activation. Because a low-level expression sufficient to induce negative signals in cells, strictly regulated. We previously demonstrated that association with clathrin-associated adaptor complex AP-2 induces internalization keeps low. However, mechanism high upon stimulation has not yet been clarified. To address this, we investigated intracellular dynamics by analyzing its localization trafficking...
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated rapid normalization serum VEGF levels improved.
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a rare multi-system disorder associated with plasma-cell dyscrasia. Several case series reports have suggested that high-dose chemotherapy autologous peripheral blood stem-cell transplantation efficacious treatment, but this not indicated for elderly patients renal failure.To investigate the effects of thalidomide treatment POEMS syndrome.Nine patients, who were chemotherapy, treated thalidomide....
To systematically study abnormalities in cytokine profiles polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, which has been increasingly recognized as a cause of demyelinating neuropathy associated with plasma cell dyscrasia elevated serum level vascular endothelial growth factor (VEGF).In this case-control study, we measured levels 27 cytokines patients POEMS syndrome using multiplex suspension array system, compared them those controls. In 10...
Abstract Purpose: EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger trimethylation H3K27 (H3K27me3) to repress transcription target genes are implicated in pathogenesis various cancers including multiple myeloma prostate cancer. Here, we investigated preclinical effects UNC1999, a dual inhibitor combination with proteasome inhibitors on Experimental Design: In vitro vivo efficacy UNC1999 was evaluated cell lines, primary patient cells, xenograft model....
The purpose of this trial was to evaluate the efficacy 2-year consolidation therapy with nilotinib, at a dose 300 mg twice daily, for achieving treatment-free remission in chronic myeloid leukemia patients deep molecular response (BCR-ABL1IS ≤0.0032%). Successful defined as no confirmed loss response. We recruited 96 Japanese patients, whom 78 sustained during phase and were therefore eligible discontinue nilotinib phase; these, 53 (67.9%; 95% confidence interval: 56.4–78.1%) remained free...
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There increasing evidence that high-dose chemotherapy autologous peripheral blood stem transplantation (Auto-PBSCT) an efficacious treatment.To elucidate the extent time course of neurologic improvement after Auto-PBSCT in patients POEMS syndrome.Clinical electrophysiologic findings nine were reviewed. The median follow-up period was...
<h3>Objective</h3> Vascular endothelial growth factor (VEGF) plays an essential role in the pathophysiology of polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome. Anti-VEGF antibody (bevacizumab) appears to be attractive therapeutic option. The aim this study is investigate effects bevacizumab for patients with POEMS <h3>Methods</h3> We reported six treated reviewed literature. <h3>Results</h3> serum VEGF levels decreased immediately after...
Abstract Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure mammals. Recent studies have confirmed its presence and metabolic role humans. Defining the physiological regulation BAT therefore great importance for developing strategies to treat diseases. Here we show that soluble form low-density lipoprotein receptor relative, LR11/SorLA (sLR11), suppresses thermogenesis a cell-autonomous manner. Mice lacking LR11 are protected from diet-induced obesity...
Objective POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia overproduction of vascular endothelial growth factor (VEGF). VEGF assumed to be useful in monitoring activity, because levels usually decrease after treatment. However, there no study investigate whether the extent correlates with clinical outcome. We tested predictive efficacy serum syndrome. Method This was an institutional...
Tyrosine kinase inhibitors (TKI) improve the prognosis of patients with chronic myelogenous leukemia (CML) by inducing substantial deep molecular responses (DMR); some have successfully discontinued TKI therapy after maintaining DMR for ≥1 year. In this cessation study, we investigated optimal conditions dasatinib discontinuation in who maintained ≥2 years. This study included 54 CML were enrolled a D-STOP multicenter prospective trial, had achieved DMR, and 2-year consolidation. Peripheral...
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), ability TKIs to eradicate CML remains uncertain and patients must continue TKI therapy for indefinite periods. In this study, we performed whole-exome sequencing identify somatic mutations in 24 with newly diagnosed phase who were registered JALSG CML212 study. We identified 191 other than BCR-ABL1 fusion gene (median 8, range 1-17). Age, hemoglobin concentration white...
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a cell costimulation receptor that delivers inhibitory signals upon activation. Although the tyrosine-based motif (165YVKM) within its cytoplasmic tail has been shown to associate in vitro with Src homology 2 domain–containing tyrosine phosphatase (SHP-2) and phosphatidylinositol 3 kinase phosphorylation, mechanism of negative signaling remains unclear. Here, we report new based on analysis murine clones transfected various mutants CTLA-4. Upon...