A5087266520- Muscle activation and electromyography studies
- Body Composition Measurement Techniques
- Muscle Physiology and Disorders
- Electrical and Bioimpedance Tomography
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neural Engineering
- Peripheral Nerve Disorders
- Advanced Sensor and Energy Harvesting Materials
- Spaceflight effects on biology
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Health and Medical Research Impacts
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Exercise and Physiological Responses
- Sports injuries and prevention
- Musculoskeletal pain and rehabilitation
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Ion channel regulation and function
- Nutrition and Health in Aging
- Cerebral Palsy and Movement Disorders
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
Hadassah Medical Center
2002-2024
Beth Israel Deaconess Hospital
1996-2024
Dana-Farber/Harvard Cancer Center
2023
Berenson Allen Center for Noninvasive Brain Stimulation
2019-2022
Community Catalyst
2022
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Harvard University Press
2003-2020
Objective Infantile‐onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death preceding age 2. Clinical trials this population require an understanding disease progression and identification meaningful biomarkers to hasten therapeutic development predict outcomes. Methods A longitudinal, multicenter, prospective natural history study enrolled 26 SMA infants 27 control aged <6 months. Recruitment occurred at 14 centers over 21...
Advances in stem cell biology have generated intense interest the prospect of transplanting cells into nervous system for treatment neurodegenerative diseases. Here, we report results an ongoing phase I trial intraspinal injections fetal‐derived neural stems patients with amyotrophic lateral sclerosis (ALS). This is a first‐in‐human clinical goal assessing safety and tolerability surgical procedure, introduction spinal cord, use immunosuppressant drugs this patient population. Twelve...
Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon development preventive/therapeutic strategies represent public health priorities. present document reports results a recent meeting International Working Group on Sarcopenia (a task force consisting geriatricians scientists from academia industry) held June 7-8, 2011 Toulouse (France). was specifically focused at gaining...
The US Food and Drug Administration-approved trial, "A Phase 1, Open-Label, First-in-Human, Feasibility Safety Study of Human Spinal Cord-Derived Neural Stem Cell Transplantation for the Treatment Amyotrophic Lateral Sclerosis, Protocol Number: NS2008-1," is complete. Our overall objective was to assess safety feasibility stem cell transplantation into lumbar and/or cervical spinal cord regions in amyotrophic lateral sclerosis (ALS) subjects.Preliminary results have been reported on initial...
To test the safety of spinal cord transplantation human stem cells in patients with amyotrophic lateral sclerosis (ALS) escalating doses and expansion trial to multiple clinical centers.This open-label included 15 participants at 3 academic centers divided into 5 treatment groups receiving increasing by numbers cells/injection injections. All received bilateral injections cervical (C3-C5). The final group both lumbar (L2-L4) through 2 separate surgical procedures. Participants were assessed...
Electrical impedance myography (EIM), a non-invasive, electrophysiological technique, has preliminarily shown value as an ALS biomarker. Here we perform multicenter study to further assess EIM’s potential for tracking ALS. patients were enrolled across eight sites. Each subject underwent EIM, handheld dynamometry (HHD), and the Functional Rating Scale-revised (ALSFRS-R) regularly. Techniques compared by assessing coefficient of variation (CoV) in rate decline each technique’s correlation...
Improved outcome measures are necessary to reduce sample size and increase power in amyotrophic lateral sclerosis (ALS) clinical trials. Motor unit number estimation (MUNE) is a potentially attractive tool. MUNE methods previously employed multicenter trials exhibited excessive variability were prone artifact.To evaluate modification of standard incremental natural history study subjects with ALS.Fifty healthy evaluated twice 71 ALS studied repeatedly for up 500 days. Side nerve was based on...
This study prospectively assessed putative promising biomarkers for use in assessing infants with spinal muscular atrophy (SMA).This prospective, multi-center natural history targeted the enrollment of SMA and healthy control less than 6 months age. Recruitment occurred at 14 centers within NINDS National Network Excellence Neuroscience Clinical Trials (NeuroNEXT) Network. Infant motor function scales electrophysiological, protein molecular were baseline subsequent visits.Enrollment began...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. Clinical studies have demonstrated cortical and spinal neuron hyperexcitability using transcranial magnetic stimulation threshold tracking nerve conduction studies, respectively, although metrics excitability not been used as pharmacodynamic biomarkers in multi-site clinical trials.To ascertain whether ezogabine decreases ALS.This double-blind, placebo-controlled phase 2 randomized...
Abstract Objective To determine the potential for improving amyotrophic lateral sclerosis (ALS) clinical trials by having patients or caregivers perform frequent self‐assessments at home. Methods and Participants We enrolled ALS into a nonblinded, longitudinal 9‐month study in which obtained daily data using several different instruments, including slow‐vital capacity device, hand grip dynamometer, an electrical impedance myography‐based fitness activity tracker, speech app, functional...
Electromyography (EMG) and magnetic resonance imaging (MRI) are commonly used in the diagnosis of cervical lumbosacral radiculopathy, but agreement between two studies is unknown. We retrospectively studied 47 patients with a clinical history compatible either or radiculopathy who were evaluated both an EMG spine MRI within 2 months each other. Among these patients, 55% had abnormality 57% that correlated clinically estimated level radiculopathy. The agreed majority (60%) normal 11 abnormal...
Localized bioimpedance analysis is a novel, noninvasive technique with potential application to neuromuscular disease. In this procedure, high-frequency alternating current passed through muscle, and parameters related the consequent voltage pattern are evaluated. Currents flowing perpendicular muscle fibers encounter many more cell membranes than do currents parallel them, producing surface patterns that altered by Using technique, 45 normal subjects 25 patients various diseases were...
Abstract Electrical impedance myography (EIM) is a non‐invasive, painless technique for the evaluation of neuromuscular disease, and here we evaluate its potential application in spinal muscular atrophy (SMA). Twenty‐one SMA patients 18 healthy children underwent EIM biceps brachii tibialis anterior using commercially available device. Hand‐held dynamometry ultrasound assessment subcutaneous fat thickness were also performed. All parameters differed significantly between both normal subjects...