A5019385985- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Body Composition Measurement Techniques
- Muscle Physiology and Disorders
- melanin and skin pigmentation
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Neurogenetic and Muscular Disorders Research
- Prosthetics and Rehabilitation Robotics
- Sleep and Wakefulness Research
- Advanced Sensor and Energy Harvesting Materials
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Innovative Energy Harvesting Technologies
- Balance, Gait, and Falls Prevention
- Cardiovascular Syncope and Autonomic Disorders
- Pain Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Skin Protection and Aging
- Genomic variations and chromosomal abnormalities
- Neural dynamics and brain function
- Neurological disorders and treatments
- RNA regulation and disease
Stanford University
2016-2022
Brown University
2012-2018
Allen Institute for Brain Science
2018
Harvard University
2008-2010
Beth Israel Deaconess Medical Center
2008-2010
The photopigment melanopsin confers photosensitivity upon a minority of retinal output neurons. These intrinsically photosensitive ganglion cells (ipRGCs) are more diverse than once believed, comprising five morphologically distinct types, M1 through M5. Here, in mouse retina, we provide the first in-depth characterization M4 cells, including their structure, function, and central projections. apparently correspond to ON α earlier reports, easily distinguished from other ipRGCs by very large...
Abstract We have identified a novel, sixth type of intrinsically photosensitive retinal ganglion cell (ipRGC) in the mouse—the M6 cell. Its spiny, highly branched dendritic arbor is bistratified, with dendrites restricted to inner and outer margins plexiform layer, co‐stratifying processes other ipRGC types. show that cells are by far most abundant labeled adult pigmented Cdh3‐GFP BAC transgenic mice. A few M5 ipRGCs also labeled, but no RGC types were encountered. Several distinct subnuclei...
Abstract Electrical impedance myography (EIM) is a non‐invasive, painless technique for the evaluation of neuromuscular disease, and here we evaluate its potential application in spinal muscular atrophy (SMA). Twenty‐one SMA patients 18 healthy children underwent EIM biceps brachii tibialis anterior using commercially available device. Hand‐held dynamometry ultrasound assessment subcutaneous fat thickness were also performed. All parameters differed significantly between both normal subjects...
Localized impedance methods can provide useful approaches for assessing neuromuscular disease. The mechanism of these changes remains, however, uncertain. In order to begin understand the relation muscle pathology surface values, 8 immature rats, 12 mature rats and that had undergone sciatic crush were killed. Measurement was made on tissue from gastrocnemius each animal in an cell, conductivity relative permittivity calculated both longitudinal transverse directions frequencies 2 kHz 1 MHz....
OBJECTIVE To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness sleep. RESEARCH DESIGN AND METHODS Normal subjects, subjects without neuropathy, with small-fiber polyneuropathy, those advanced were categorized based on neurological examination, nerve conduction studies, quantitative sensory testing. Subjects underwent foot temperature monitoring using an iButton device attached to a second for recording ambient temperature....
Background: Patient complaints of excessively warm or cold feet are common in medical practice. Such symptoms can be caused by underlying vascular neurologic disease, and measurement foot temperature during daily activity sleep could provide a deeper understanding their actual thermal basis. Methods: We used Thermochron iButton to assess surface variation its relationship ambient the day with at night 39 healthy individuals aged 18 65 years temperate region United States. simultaneously...
Hyperexcitability of brain circuits is a common feature autism spectrum disorders (ASDs). Genetic deletion chromatin-binding protein, retinoic acid induced 1 ( RAI1 ), causes Smith–Magenis syndrome (SMS). SMS syndromic ASD associated with intellectual disability, autistic features, maladaptive behaviors, overt seizures, and abnormal electroencephalogram (EEG) patterns. The molecular neural mechanisms underlying activity in remain unclear. Here we show that panneural Rai1 deletions mice...
Abstract Electrical impedance myography (EIM) is a method for non‐invasively and quantitatively assessing muscle health, in which the major outcome parameter, phase (θ), decreases diseased states. In order to create set of normal reference values, we performed 50‐kH Z EIM 5 muscles 87 healthy individuals, using θ as variable. Because distributions data were mostly skewed, logarithmic transformations performed, resulting fitted quadratic functions. The lower limit was by plotting 95%...
Objectives: To assess changes in electrical impedance myography (EIM) parameters amyotrophic lateral sclerosis (ALS). Methods: Ten patients with ALS and a cohort of normal subjects underwent EIM testing tibialis anterior. Montages using voltage current electrodes placed at distance (far) close proximity (near) were compared. The parameters, resistance ( R ), reactance X phase (θ) the ALS, compared values. Results: θ measured 50 kHz near montage was most sensitive to presence 9 10 having...
Primary objective: To create a system for the acquisition of multi-angle, multifrequency muscle impedance data.
Electrical impedance methods can be used to evaluate and monitor neuromuscular disease states. Recently, we have applied tetrapolar surface electrical the gastrocnemius muscle of rat for this purpose substantial changes in parameters after sciatic nerve crush identified. In order able study additional animal models disease, however, it would highly desirable perform such measurements mouse. Yet small size mouse presents a technical challenge. study, basic approach performing measurements. A...