Shien Shen

ORCID: 0009-0007-3541-2055
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About
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Research Areas
  • Oral microbiology and periodontitis research
  • Pancreatic and Hepatic Oncology Research
  • Neuroendocrine Tumor Research Advances
  • Pediatric health and respiratory diseases
  • Advanced biosensing and bioanalysis techniques
  • Retinal Imaging and Analysis
  • Cancer Treatment and Pharmacology
  • Dietary Effects on Health
  • Salivary Gland Disorders and Functions
  • Birth, Development, and Health
  • Platelet Disorders and Treatments
  • Hepatitis C virus research
  • Epigenetics and DNA Methylation
  • Drug-Induced Hepatotoxicity and Protection
  • Chronic Kidney Disease and Diabetes
  • RNA modifications and cancer
  • Immunodeficiency and Autoimmune Disorders
  • Blood groups and transfusion
  • Gout, Hyperuricemia, Uric Acid
  • Glycosylation and Glycoproteins Research
  • Blood Pressure and Hypertension Studies
  • Gastroesophageal reflux and treatments
  • Circadian rhythm and melatonin
  • Helicobacter pylori-related gastroenterology studies
  • Respiratory viral infections research

Shenzhen University
2024

Shanghai Jiao Tong University
2022-2023

Shanghai First People's Hospital
2022-2023

Zhejiang Hospital
2014-2021

Chronic pancreatitis (CP) is characterized by progressive fibrosis and exocrine dysregulation, which have long been considered irreversible. As a peripheral oscillator, the pancreas harbors autonomous self-sustained timekeeping systems in both its endocrine compartments, although role of latter remains poorly understood. By using different models CP established mice with dysfunctional pancreatic clocks, we found that local clock played an important pathology, genetic or external disruption...

10.1126/scitranslmed.abn3586 article EN Science Translational Medicine 2022-09-28

Abstract Background To evaluate the long-term efficacy of transoral incisionless fundoplication (TIF) with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease (GERD). Methods A total 16 patients proton pump inhibitor-dependent had undergone TIF by MUSE in Shanghai General Hospital (Shanghai, China)from March 2017 to December 2018. Patients were followed up at 6 months, and GERD-health-related quality life (GERD-HRQL) questionnaire score, GERD (GERD-Q)...

10.1007/s10388-023-00992-3 article EN cc-by Esophagus 2023-03-06

Aim: In the present study, we aimed to investigate effects of Fenbufen treatment on SAP model induced by caerulein and lipopolysaccharide. Background: Severe acute pancreatitis (SAP) is an extremely dangerous disease with high mortality, which associated inflammatory response acinar cell death. The caspase family plays important role in death, such as caspase-1 caspase-11 pyroptosis. recent years, caspases have been shown be a novel pharmacological target Fenbufen. Objective: Effects...

10.2174/1874467217666230511095540 article EN cc-by Current Molecular Pharmacology 2023-05-11

BACKGROUND To explore the correlation between serum uric acid (UA) level and liver function indexes in patients with hepatitis B, so as to provide guidance for prediction treatment of damage B. METHODS Four hundred eighty-five B were selected case group 312 without matched same period control group. The difference blood UA each was analyzed, ALT, AST CREA analyzed. RESULTS significantly higher than that non-hepatitis group, statistically significant (p = 0.000). Correlation analysis showed...

10.7754/clin.lab.2020.200904 article EN Clinical Laboratory 2021-01-01

Objective To establish normal reference ranges for serum cystatin C(Cys C)in relatively healthy middle-aged and elderly(>50 years)Chinese individuals. Methods A total of 1087 candidates were consecutively selected Cys-C levels measured by transmission turbidimetry.Frequency analysis histogram used to the 95% confidence range according methods provided CLSI(C28-A2). Results Based on definition verification procedures clinical laboratory ranges(CLSI C28-A2, second edition),...

10.3760/cma.j.issn.0254-9026.2016.09.017 article EN Zhonghua laonian yixue zazhi 2016-09-14
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