A5101686307- Structural Health Monitoring Techniques
- Seismic Performance and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Lattice Boltzmann Simulation Studies
- Structural Engineering and Vibration Analysis
- Seismic Waves and Analysis
- Fluid Dynamics and Vibration Analysis
- Geotechnical Engineering and Underground Structures
- Medical Imaging Techniques and Applications
- Tryptophan and brain disorders
- Remote Sensing and Land Use
- Magnolia and Illicium research
- Stress Responses and Cortisol
- Wind and Air Flow Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- earthquake and tectonic studies
- Neuroendocrine regulation and behavior
- Pharmacological Effects of Natural Compounds
- Radiomics and Machine Learning in Medical Imaging
- Fluid Dynamics and Turbulent Flows
- Infrastructure Maintenance and Monitoring
- Adenosine and Purinergic Signaling
- Advanced Algorithms and Applications
- Geoscience and Mining Technology
- Aerosol Filtration and Electrostatic Precipitation
Nanjing University of Chinese Medicine
2013-2025
Chongqing University
2007-2023
Shanghai University of Electric Power
2022-2023
Sichuan Highway Design and Research Institute
2023
Johns Hopkins Medicine
2022
Johns Hopkins University
2001-2022
Nanjing Medical University
2013-2018
Drug Discovery Laboratory (Norway)
2017
Jiangsu Vocational College of Medicine
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Neutrophil aggregation and clearance are important factors affecting neuroinflammatory injury during acute ischemic stroke. Emerging evidence suggests that energy metabolism is essential for microglial functions, especially phagocytosis, which determines the degree of brain injury. Here, we demonstrate Resolvin D1 (RvD1), a lipid mediator derived from docosahexaenic acid (DHA), promotes phagocytosis neutrophils by microglia, thereby reducing neutrophil accumulation in alleviating...
It is generally recognized that the inflammatory reaction in glia one of important pathological factors brain ischemic injury. Our previous study has revealed opening ATP-sensitive potassium (K-ATP) channels could attenuate glial inflammation induced by stroke. However, detailed mechanisms are not well known.Primary cultured astrocytes separated from C57BL/6 mice were subjected to oxygen-glucose deprivation (OGD); cellular injuries determined via observing changes morphology and cell...
Purpose Radioembolization with yttrium‐90 microspheres may be optimized patient‐specific pretherapy treatment planning. Dose verification and validation of planning methods require quantitative imaging the post‐therapy distribution (Y‐90). Methods for Y‐90 using both bremsstrahlung SPECT PET have previously been described. The purpose this study was to compare two modalities quantitatively in humans. Calibration correction factors a non‐time‐of‐flight system without compensation prompt...
Abstract Oridonin, a natural diterpenoid compound extracted from Chinese herb, has been proved to exert anti‐oxidative stress effects in various disease models. The aim of the present study was investigate protective oridonin on oxidative stress‐induced endothelial injury ischaemic stroke. We found repaired blood‐brain barrier (BBB) integrity presented with upregulation tight junction proteins (TJ proteins) expression, inhibited infiltration periphery inflammatory cells and neuroinflammation...
Lipid metabolism dysfunction is widely involved in the pathological process of acute ischemic stroke (AIS). The coordination lipid between neurons and astrocytes great significance. However, full scope dynamic changes function key lipids during AIS remain unknown. Hence, identifying alterations characterizing their roles importance.
Summary Background and purpose Our previous studies have demonstrated adenosine triphosphate‐sensitive potassium channel ( K ATP channel) openers could protect against inflammatory response in brain disease, but little is known about the mechanisms involved inhibiting neuroinflammation. Methods results In present study, we found that oxygen–glucose deprivation OGD ) resulted BV ‐2 cells activation, significantly increased tumor necrosis factor‐alpha interleukin‐1beta IL ‐1β) levels,...
Abstract Fingolimod ( FTY 720) is used as an immunosuppressant for multiple sclerosis. Numerous studies indicated its neuroprotective effects in stroke. However, the mechanism remains to be elucidated. This study was intended investigate mechanisms of phosphorylated 720 pFTY 720), which principle active molecule regulating astrocyte‐mediated inflammatory responses induced by oxygen‐glucose deprivation OGD ). Results demonstrated that could protect astrocytes against ‐induced injury and...
Oxidative stress-mediated astrocytic damage contributes to nerve injury and the development of depression, especially under stress conditions. Peroxisomes pexophagy are essential for balancing oxidative protein degradation products. Our previous findings suggest that peroxisome proliferators-activated receptor β/δ (PPARβ/δ) activation significantly alleviates depressive behaviors by preventing injury. However, underlying mechanisms remain unclear. In present study, we established treating...
Abstract In this paper, we propose a new lattice Boltzmann model for the compressible Navier–Stokes equations. The is based on three‐energy‐level and three‐speed equation by using method of higher moments equilibrium distribution functions. As 25‐bit model, obtained functions equations with second accuracy truncation errors. numerical examples show that can be used to simulate shock waves, contact discontinuities supersonic flows around circular cylinder. results are compared those...
Background and Purpose ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP that mainly expressed on glia stroke remain unclear. Methods Results In this study, we found expression Kir6.1 was significantly decreased ischemic area C57BL/6J mice after 1-h middle cerebral artery occlusion (MCAO) 24-h reperfusion. Then, subjected heterozygote knockout...