A5114909951- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- PARP inhibition in cancer therapy
- Polymer crystallization and properties
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- biodegradable polymer synthesis and properties
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- Polyamine Metabolism and Applications
- Ferroptosis and cancer prognosis
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Receptor Mechanisms and Effects
- Fungal Plant Pathogen Control
- Cancer Treatment and Pharmacology
State Key Laboratory of Biotherapy
2013-2024
Sichuan University
2015-2024
West China Hospital of Sichuan University
2022
Johns Hopkins University
2018
Johns Hopkins Medicine
2018
Breast cancer stem cells (BCSCs), which are characterized by a capacity for unlimited self-renewal and generation of the bulk cell population, play critical role in relapse metastasis. Hypoxia is common feature microenvironment that stimulates specification maintenance BCSCs. In this study, we found hypoxia increased expression adenosine receptor 2B (A2BR) human breast through transcriptional activity hypoxia-inducible factor 1. The binding to A2BR promoted BCSC enrichment activating protein...
X-ray induced photodynamic therapy (X-PDT) circumvents the poor penetration depth of conventional PDT with minimal radio-resistance generation. However, X-PDT typically requires inorganic scintillators as energy transducers to excite neighboring photosensitizers (PSs) generate reactive oxygen species (ROS). Herein, a pure organic aggregation-induced emission (AIE) nanoscintillator (TBDCR NPs) that can massively both type I and II ROS under direct irradiation is reported for hypoxia-tolerant...
Triple-negative breast cancer (TNBC) has a poor prognosis due to its aggressive characteristics and lack of targeted therapies. Cytotoxic chemotherapy may reduce tumor bulk, but leaves residual disease the persistence chemotherapy-resistant stem cells (BCSC), which are critical for recurrence metastasis. Here, we demonstrate that hypoxia-inducible factor (HIF)-1-dependent regulation mitogen-activated protein kinase (MAPK) signaling pathways contributes chemotherapy-induced BCSC enrichment....
Abstract Cardiac hypertrophy is the main cause of heart failure and sudden death in patients. But pathogenesis unclear. Angiotensin II may contribute to cardiac response pressure overload. In angiotensin II‐treated cardiomyocytes, there a larger cross‐sectional area, more apoptosis cells, reduction irisin expression. An increase P62, an autophagy flux index, as well LC3II, were observed cardiomyocytes after II‐induced injury. Surprisely, supplementation increased LC3II expression decreased...
Radiation-induced lung injury (RILI) presents a common and major obstacle in the radiotherapy of thoracic cancers. The aim this study was to examine whether RILI could be alleviated by mesenchymal stem cells (MSCs) expressing soluble transforming growth factor-β (TGF-β) type II receptor via an adenovirus (Ad-sTβR). Here, we systemically administered male MSCs into female mice challenged with irradiation. data showed that either or Ad-sTβR transduced (Ad-sTβR-MSCs) specifically migrated...
Endoplasmic reticulum stress (ERS) is usually involved in tumor development and progression, anticancer agents have recently been recognized to induce ERS. Cucurbitacin-I showed a potent action by inducing apoptosis through the inhibition of signal transducer activator transcription 3 pathway triggering autophagic cell death. It not known whether ERS mediates cancer death induced cucurbitacin-I. Here, we investigated role cucurbitacin-I-treated SKOV3 ovarian cells PANC-1 pancreatic cells. We...
Abstract Breast cancer patients may initially benefit from cytotoxic chemotherapy but experience treatment resistance and relapse. Chemoresistant breast stem cells (BCSCs) play a pivotal role in recurrence metastasis, however, identification eradication of BCSC population are challenging. Here, an mRNA‐based signature is developed using machine learning strategy to evaluate stemness primary patient samples. Using the signature, critical polyamine anabolism regulation chemotherapy‐induced...
Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, radiobiological mechanisms ablative HFRT remain largely unknown. The purpose this study was to investigate dynamic changes tumor vessels and perfusion during after radiotherapy. Lewis carcinoma-bearing mice were treated sham (control) 12 Gy in 1 fraction (12 Gy/1F) 36 3 fractions (36 Gy/3F)....
Radiation‑induced lung injury (RILI) is a common and major obstacle in thoracic cancer radiotherapy, resulting considerable morbidity limiting the dose of radiation. However, an effective treatment option remains to be established. Therefore, present study aimed investigate effects azithromycin (AZM) acute RILI with mouse model. In study, C57BL/6 mice were given single irradiation 16 Gy administered orally AZM. The histopathological findings, levels malondialdehyde (MDA; indicator oxidative...
Angiogenesis and inflammation are crucial processes through which the tumor microenvironment (TME) influences progression. In this study, we showed that peroxisome proliferator‐activated receptor γ (PPARγ) is not only expressed in CT26 4T1 cell lines but also cells of TME, including endothelial tumor‐associated macrophages (TAM). addition, rosiglitazone may induce vessel normalization reduce TAM infiltration. Additionally, tumor‐bearing mice treated with combination radiotherapy a...
The morphology evolution in polycarbonate/polyethylene (PC/PE) blends with and without compatibilization a twin-screw extruder was studied using scanning electron microscope (SEM). effects of screw speed compatibilizer on the PC/PE blend during extrusion were discussed detail. It found that shape size dispersed phase uncompatibilized are both influenced by speed. can be affected increasing speed, particle decreases As compatibilizer, addition (ethylene-methyl acrylate-glycidyl methacrylate)...