A5063615927- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Grouting, Rheology, and Soil Mechanics
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Mechanisms of cancer metastasis
- Supply Chain and Inventory Management
- Endometrial and Cervical Cancer Treatments
- Spinal Hematomas and Complications
- Probabilistic and Robust Engineering Design
- Adenosine and Purinergic Signaling
- Optimization and Mathematical Programming
- Cancer Genomics and Diagnostics
- Water resources management and optimization
Second People’s Hospital of Yibin
2017-2025
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
University of Electronic Science and Technology of China
2019-2020
China Railway Construction Corporation (China)
2020
Sichuan Cancer Hospital
2017
State Key Laboratory of Biotherapy
2013
Sichuan University
2011-2012
Abstract Tumor metastasis is one of the major causes high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation STAT3 signaling plays a critical role HCC metastasis. RNA binding protein (RBP)–mediated posttranscriptional regulation involved precise control signal transduction, including signaling. In this study, we investigated whether RBPs are important regulators The RBP MEX3C was found to be significantly upregulated highly metastatic and correlated poor...
Advanced gastric cancer (GC) exhibits a high recurrence rate and dismal prognosis. Myocyte enhancer factor 2c (MEF2C) was found to contribute the development of various types cancer. Therefore, our aim is develop prognostic model that predicts prognosis GC patients initially explore role MEF2C in immunotherapy for GC. Transcriptome sequence data obtained from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) PRJEB25780 cohort subsequent immune infiltration analysis,...
Abstract Background GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on unique interaction between microenvironment (TME). However, currently available methods for prognostic prediction are not satisfactory. Therefore, this study aims construct novel model that integrates relevant gene sets predict clinical efficacy of immunotherapy prognosis patients based machine learning. Methods Seven datasets were collected from Gene...
Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, radiobiological mechanisms ablative HFRT remain largely unknown. The purpose this study was to investigate dynamic changes tumor vessels and perfusion during after radiotherapy. Lewis carcinoma-bearing mice were treated sham (control) 12 Gy in 1 fraction (12 Gy/1F) 36 3 fractions (36 Gy/3F)....
The CTC1-STN1-TEN1 (CST) complex plays a crucial role in telomere replication and genome stability. However, the detailed mechanisms of CST regulation cancer remain largely unknown. Here, we perform comprehensive analysis across 33 types using multi-omic data from Cancer Genome Atlas. In genomic landscape, identify CTC1/STN1 deletion mutation TEN1 amplification as dominant alteration events. Expressions CTC1 STN1 are decreased tumors compared to those adjacent normal tissues. Clustering...
Nitidine chloride (NC) has been reported to exert its anti-tumor activity in various types of human cancers. However, the molecular mechanism NC-mediated tumor suppressive function is largely unclear. In current study, we used several approaches such as MTT, FACS, RT-PCR, Western blotting analysis, invasion assay, transfection, explore basis NC-triggered anti-cancer activity. We found that NC inhibited cell growth, induced apoptosis, caused cycle arrest ovarian cancer cells. Emerging...
Gastric cancer (GC) is one of the most common clinical malignant tumors worldwide, with high morbidity and mortality. Presently, overall response rate to immunotherapy low, current methods for predicting prognosis GC are not optimal. Therefore, novel biomarkers accuracy, efficiency, stability, performance ratio wide application needed. Based on public data sets, Chemotherapy Cohort Immunotherapy from Sun Yat-sen University Cancer Center, a series bioinformatics analyses, such as differential...
// Dan Zheng 1, 2, * , Hua-Ping Mou 3, Peng Diao 4, Xiao-Ming Li 5 Chuan-Li Zhang 3 Jing Jiang Jia-Lian Chen Li-Shuai Wang 6 Qiu Guang-Yuan Zhou Jie Chuan Lin and Zhi-Ping Yuan 5, 1 Department of Head Neck Mammary Gland Oncology, Medical Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. 2 State Key Laboratory Biotherapy/Collaborative Innovation Center Biotherapy, The Gynecology, Second People's Hospital Province, Yibin City, Yibin, 644000, 4 Institute,...
<div>Abstract<p>Tumor metastasis is one of the major causes high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation STAT3 signaling plays a critical role HCC metastasis. RNA binding protein (RBP)–mediated posttranscriptional regulation involved precise control signal transduction, including signaling. In this study, we investigated whether RBPs are important regulators The RBP MEX3C was found to be significantly upregulated highly metastatic and...
<div>Abstract<p>Tumor metastasis is one of the major causes high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation STAT3 signaling plays a critical role HCC metastasis. RNA binding protein (RBP)–mediated posttranscriptional regulation involved precise control signal transduction, including signaling. In this study, we investigated whether RBPs are important regulators The RBP MEX3C was found to be significantly upregulated highly metastatic and...
Supplementary Data from MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma
Supplementary Data from MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma
Abstract This paper presents a design and construction schemes of pipe jacking project in Kunming, China detail. The underpass, having width 6.9 m height 4.9 m, was jacked 46m water-filled clay under busy viaduct with 4.5 overburden soil., Some adjustments have been made to the process due characteristics soil layer, surrounding environment existing pipeline. During whole process: passes through shallow confined aquifer high water content void ratio, it is easy produce rheology. In addition,...