A5085993678- RNA modifications and cancer
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Cancer Mechanisms and Therapy
- Protein Tyrosine Phosphatases
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Biomedical Research and Pathophysiology
- Chromatin Remodeling and Cancer
- Lymphatic System and Diseases
- Enzyme Structure and Function
- Trauma and Emergency Care Studies
- Caveolin-1 and cellular processes
- Immunotherapy and Immune Responses
- Cancer Risks and Factors
Sun Yat-sen University Cancer Center
2018-2023
Sun Yat-sen University
2018-2023
State Key Laboratory of Oncology in South China
2020-2023
Nanjing Maternity and Child Health Care Hospital
2019
Jiangsu Province Hospital
2019
Nanjing Medical University
2019
Northwestern University
2019
Bone metastasis pattern in initial metastatic breast cancer: a population-based study Zhenchong Xiong,1–3,* Guangzheng Deng,1–3,* Xinjian Huang,1–3,* Xing Li,1–3 Xinhua Xie,1–3 Jin Wang,1–3 Zeyu Shuang,1–3 Xi Wang1–3 1Department of Breast Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China; 2State Key Laboratory Oncology Southern China, 3Collaborative Innovation Center for Medicine, China *These authors contributed equally to this work Purpose: is one the most common sites cancer...
Nicotine addiction and the occurrence of lymph node spread are two major significant factors associated with esophageal cancer's poor prognosis; however, nicotine's role in inducing lymphatic metastasis cancer remains unclear. Here we show that OTU domain-containing protein 3 (OTUD3) is downregulated by nicotine correlates prognosis heavy-smoking patients. OTUD3 directly interacts ZFP36 ring finger (ZFP36) stabilizes it inhibiting FBXW7-mediated K48-linked polyubiquitination. binds VEGF-C...
Abstract Tumor metastasis is one of the major causes high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation STAT3 signaling plays a critical role HCC metastasis. RNA binding protein (RBP)–mediated posttranscriptional regulation involved precise control signal transduction, including signaling. In this study, we investigated whether RBPs are important regulators The RBP MEX3C was found to be significantly upregulated highly metastatic and correlated poor...
Population-based estimates are lacking for the temporal trends in contralateral breast cancer (CBC) risk patients with (BC). Data BC diagnosed CBC were collected from Surveillance, Epidemiology, and End Results database. incidence was calculated using Kaplan-Meier method trend assessed joinpoint regression. Survival analysis propensity scoring (PS) multivariate Cox regression a competing model. We found that 10,944 of 212,630 early-stage subsequently secondary breast. The 5-, 10-, 15-,...
Rationale: Chemoresistance is a major challenge in the clinical management of patients with breast cancer. Mutant p53 proteins tend to form aggregates that promote tumorigenesis cancers. We here aimed explore mechanism for generation mutant cancer and assess its role inducing chemoresistance. Methods: Expression BCL2-associated athanogene 2 (BAG2) was evaluated by qRT-PCR, western blotting, immunohistochemistry patient specimens. The significance BAG2 expression prognosis assessed...
HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating assembly signal transduction complexes response to extrinsic stimuli. However, role protein breast cancer remains unclear.
Chemoresistance is a major obstacle to the treatment of triple-negative breast cancer (TNBC), which has poor prognosis. Increasing evidence demonstrated essential role stem cells (CSCs) in process TNBC chemoresistance. However, underlying mechanism remains unclear. In present study, we report that block proliferation 1 (BOP1) serves as key regulator chemoresistance TNBC. BOP1 expression was significantly upregulated chemoresistant tissues, and high correlated with shorter overall survival...
Abstract Balancing mRNA nuclear export kinetics with its decay is critical for homeostasis control. How this equilibrium aberrantly disrupted in esophageal cancer to acquire stem cell properties remains unclear. Here we find that the RNA-binding protein interleukin enhancer binding factor 2 (ILF2) robustly upregulated by nicotine, a major chemical component of tobacco smoke, via activation JAK2/STAT3 signaling and significantly correlates poor prognosis heavy-smoking patients cancer. ILF2...
Abstract Background Triple negative breast cancer (TNBC) is an aggressive subtype of with high proliferative activity. TNBC tumors exhibit elevated MYC expression and altered regulatory genes, which are associated tumor progression poor prognosis; however, the underlying mechanisms by retains its mediates tumorigenesis require further exploration. Methods ACTL6A regulation target gene, CDK2, was defined using Co-IP, mass spectrometry ChIP assays. To study role in TNBC, we performed...
Macropinocytosis is an effective strategy to mitigate nutrient starvation. It can fuel cancer cell growth in nutrient-limited conditions. However, whether and how macropinocytosis contributes the rapid proliferation of hepatocellular carcinoma cells, which frequently experience inadequate supply, remains unclear. Here, we demonstrated that starvation strongly induced some cells. allowed cells acquire extracellular nutrients supported their energy supply maintain proliferation. Furthermore,...
Human epidermal growth factor receptor 2-targeted (HER2-targeted) therapy is the mainstay of treatment for HER2+ breast cancer. However, proteolytic cleavage HER2, or HER2 shedding, induces release target epitope at ectodomain (ECD) and generation a constitutively active intracellular fragment (p95HER2), impeding effectiveness anti-HER2 therapy. Therefore, identifying key regulators in shedding might provide promising targetable vulnerabilities against resistance. In current study, we found...
Purpose Survival of metastatic breast cancer (MBC) patient remains unknown and varies greatly from person to person. Thus, we aimed construct a nomogram quantify the survival probability patients with MBC. Materials Methods We had included 793 MBC calculated trends case fatality rate by Kaplan-Meier method joinpoint regression. Six hundred thirty-four between January 2004 July 2011 159 August 2013 were assigned training cohort internal validation cohort, respectively. constructed based on...
An increasing amount of research over recent years on the anti-metastasis function non-metastatic (NME) gene family has been challenged, with some studies identifying its involvement in promotion oncogenesis. Therefore, specific functions NME require redefining through a comprehensive analysis tumor heterogeneity and survival benefit. However, genes have not comprehensively investigated breast cancer (BC).In this study, ONCOMINE, GEPIA, Kaplan-Meier plotter, cBioPortal, String, metascape...
Triple negative breast cancer (TNBC) is the most aggressive subtype with high motile and invasive capacity that contributes to metastasis. Understanding mechanisms for motility of TNBC might provide novel targetable vulnerabilities tumors. Herein, we find Rhophilin-associated tail protein 1 (ROPN1) selectively overexpressed in human cell lines tissues. Overexpression ROPN1 promotes, while silencing inhibits robust migration, invasion, vivo metastasis cells. Moreover, activates RhoA signaling...
Background: Tumor-infiltrating lymphocytes (TILs) play important roles in the prediction of prognosis and neoadjuvant therapy (NAT) efficacy breast cancer (BRCA) patients, this study, we identified clinicopathological factors related to BRCA TILs, then construct validate nomogram predict high density TILs. Methods: A total 826 patients diagnosed with Sun Yat-Sen University center were enrolled cohort. TILs assessed using hematoxylin-eosin (H&E) staining by two pathologists. Complete...
Although the tumor microenvironment (TME) plays an important role in development of many cancers, its roles breast cancer, especially triple-negative cancer (TNBC), are not well studied. This study aimed to identify genes related TME and prognosis TNBC. Firstly, we identified differentially expressed (DEG) TNBC, using Expression data (ESTIMATE) datasets obtained from Cancer Genome Atlas (TCGA) Estimation Stromal Immune cells Malignant Tumor tissues. Next, survival analysis was performed...
Background: Triple-negative breast cancer (TNBC) is not sensitive to targeted therapy with HER-2 monoclonal antibody and endocrine due lack of ER, PR, receptors. TNBC a subtype the worst prognosis highest mortality rate compared other subtypes. Materials Methods: Breast cancer-related data were retrieved from The Cancer Genome Atlas (TCGA) database, 116 cases triple-negative identified data. GSE31519 dataset was Gene Expression Omnibus (GEO) comprising total 68 TNBC. Survival analysis...
Abstract Background Host immunity plays an important role in tumor development and treatment. Tumor‐infiltrating lymphocytes (TILs) have been proven to predict the efficacy of neoadjuvant therapy (NAT) breast cancer (BC) patients, but their application is limited due various reasons. This study aims explore relationship between peripheral blood (PBLs) subsets distribution NAT. Methods Between December 2017 March 2021, a total 116 BC patients appropriate for NAT Sun Yat‐Sen University center...
Abstract Adipose stromal/stem cells (ADSCs) could regulate malignancy behaviors of breast cancer, which was due to adipose-derived cytokines in part, such as leptin and resistin. Recently, peptides have been demonstrated be potential targets for cancer therapy. It's valuable analyze the characters adipose-secreted systematically. In this study, we isolated primary adipocytes from adipose tissue adjacent tumor benign lesions respectively, then co-cultured MCF-7 with (TAAs)/breast (BBAs)...
Purpose: The authors aimed to evaluate the prognostic and predictive value of androgen receptor (AR) expression in patients with luminal/human EGFR2 negative (HER2-) T1N0 breast cancer. Methods: cohort this retrospective study comprised 471 luminal/HER2- cancer who had undergone surgery between 2013 2017 authors' center. Results: AR+ tumors were associated favorable characteristics. better 5-year recurrence-free survival rates risk recurrence was greater for AR- than patients. status...