A5085671609- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Lymphoma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Neurological diseases and metabolism
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Child Nutrition and Feeding Issues
- Fungal Infections and Studies
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Graphene and Nanomaterials Applications
- Neurological disorders and treatments
- Lysosomal Storage Disorders Research
- Bioinformatics and Genomic Networks
- Dysphagia Assessment and Management
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Dementia and Cognitive Impairment Research
- Nanoparticle-Based Drug Delivery
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
Union Hospital
2024
Jilin University
2021-2024
Union Hospital
2021-2023
Creative Commons
2022
Weatherford College
2022
China Pharmaceutical University
2020-2021
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are collectively known as body (LBD). Considering the heterogeneous nature of LBD different constellations symptoms which patients can present, exact molecular mechanism underlying differences between these two isoforms is still unknown. Therefore, this study aimed to explore biomarkers potential mechanisms that distinguish PDD DLB. The mRNA expression profile dataset GSE150696 was acquired from Gene Expression Omnibus...
Cell membrane-based nanoparticles have garnered increasing attention owing to their inherent biomimetic properties, such as homotypic targeting, prolong circulation, and immune escaping mechanisms.
This study aimed to explore new core genes related the occurrence of Parkinson's disease (PD) and that can lead progression PD. The expression profile data GSE42966, which contained six substantia nigra tissues isolated from normal individuals nine patients with PD, were obtained Gene Expression Omnibus. Differentially expressed (DEGs) identified, followed by functional enrichment analysis protein-protein interaction (PPI) network construction. We then identified 10 hub analyzed their in...
This study aimed to explore the N6-methyladenosine (m6A) modification genes involved in pathogenesis of Parkinson’s disease (PD) through data analysis two sets GSE120306 and GSE22491 GEO database further its influence on cell phenotype PD. We analyzed differentially expressed function enrichment found that expression m6A-modification gene HNRNPC was significantly downregulated PD group, it played an important role DNA metabolism, RNA processing may be Then, we constructed differential line...
Introduction Parkinson’s disease (PD) is the second most common worldwide age-related neurodegenerative disorder without effective treatments. Cuproptosis a newly proposed conception of cell death extensively studied in oncological diseases. Currently, whether cuproptosis contributes to PD remains largely unclear. Methods The dataset GSE22491 was as training dataset, and GSE100054 validation dataset. According expression levels cuproptosis-related genes (CRGs) differentially expressed (DEGs)...