A5101421615- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Diabetes Treatment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Sleep and Wakefulness Research
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Biochemical effects in animals
- Diabetes and associated disorders
- Antioxidant Activity and Oxidative Stress
- FOXO transcription factor regulation
- Bone Metabolism and Diseases
- Acupuncture Treatment Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bioactive Natural Diterpenoids Research
- Alkaloids: synthesis and pharmacology
First Affiliated Hospital of Henan University
2020-2025
Affiliated Hospital of Qingdao University
2024-2025
Qingdao University
2024-2025
Huazhong University of Science and Technology
2024
Chinese PLA General Hospital
2024
Hainan General Hospital
2024
Guangxi Medical University
2024
China Academy of Chinese Medical Sciences
2023
Wangjing Hospital of China Academy of Chinese Medical Sciences
2023
China Medical University
2021
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinson disease (PD). However, little known about regulation autophagy process. In this study, we characterized aberrant activation induced by neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and demonstrated that melatonin has a protective effect on neurotoxicity. We found an excessive monkey brain tissues C6 cells, MPTP, which mediated CDK5 (cyclin-dependent kinase 5). MPTP treatment...
Objective To investigate the mechanism underlying effects of berberine (BBR) in treatment Alzheimer’s disease (AD). Methods 3 × Tg AD mice were treated with BBR for months, then open field test (OFT), novel object recognition (NOR) and Morris water maze (MWM) performed to assess behavioral performance. Hematoxylin–eosin (HE) staining, Nissl staining used examine histopathological changes. The pharmacological molecular properties obtained from TCMSP database. BBR-associated targets identified...
Exposure to brominated flame retardants (BFRs) has been linked alterations in human metabolism and disease processes. However, the relationship between BFR exposure blood lipid levels remains unclear. This study aimed investigate potential association profiles American adults. A cross-sectional was conducted using data from National Health Nutrition Examination Survey (NHANES) 2005–2016. Serum concentrations of twelve BFRs, PBB153 eleven polybrominated diphenyl ethers (PBDEs), were...
Parkinson's disease (PD) is a complex syndrome with many elements, such as chronic inflammation, oxidative stress, mitochondrial dysfunction, loss of dopaminergic neurons, build-up alpha-synuclein (α-syn) in cells, and energy depletion that drive the disease. We others have shown treatment mimetics growth factor glucagon-like peptide 1 (GLP-1) can normalize utilization, neuronal survival, dopamine levels reduce inflammation. Liraglutide GLP-1 analogue recently showed protective effects phase...
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of crystal structure initial lead bound to enabled optimization enzyme potency and antiviral activity. This afforded series potent orally bioavailable inhibitors which MK-8718 identified compound with favorable overall profile.
Background Mogroside V (MV) has anti-inflammatory properties. However, its impact on macrophage polarization under diabetic condition is yet unclear. This study aimed to investigate effects and underlying mechanisms of MV inflammatory response M1 bone marrow-derived macrophages (BMDMs) from mice.
Alzheimer's disease (AD) is the most common type of dementia worldwide. The deposition amyloid β (Aβ) one important pathological changes in AD. Autophagy, which mediates degradation toxic proteins and maintains normal neuronal function, dysfunctional AD; autophagy believed to be a critical feature Here, we evaluated vitro vivo effects traditional Chinese medicinal formula called Yizhiqingxin (YQF) on autophagy. We determined that treatment with high dose YQF improved spatial memory decreased...
Abstract Glucagon-like peptide-2 (GLP-2) is a peptide hormone that belongs to the glucagon-derived family. We have previously shown analogues of sister peptide-1 (GLP-1) showed neuroprotective effects. Here we investigated effect GLP-2 agonist in cell model Parkinsonʼs disease (PD) created by treating SH-SY5Y or Neuro-2a cells with 1-Methyl-4-phenyl-pyridine ion (MPP+). Cell viability and cytotoxicity was detected MTT LDH assays, respectively. The protein expression levels mitochondrial,...
Background: Glucagon-like peptide 2 (GLP-2) is a hormone derived from the proglucagon gene expressed in intestines, pancreas and brain. Some previous studies showed that GLP-2 improved aging Alzheimer’s disease related memory impairments. Parkinson’s (PD) progressive neurodegenerative disorder, to date, there no particular medicine reversed PD symptoms effectively. Objective: The aim of this study was evaluate neuroprotective effects analogue 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine...
Introduction Complete and specific ablation of a single dopaminergic (DA) pathway is critical step to distinguish the roles DA pathways in vivo. However, this kind technique has not been reported non-human primates. This study aimed establish lesioning method with complete ablation. Method A carefully designed infusion route based on MRI stereotactic was developed deliver highly selective toxin 1-methyl-4-phenylpyridinium (MPP+) unilaterally into multiple sites compact part substantia nigra...
Abundant evidence has shown the protective effect of aerobic exercise on central neuronal system, however, research about resistance remains limited. To evaluate and potential molecular mechanisms in improving cognition mental health, three-month-old male C57BL/6J mice underwent training for five weeks. Body parameters, cognitive performance synaptic plasticity were then assessed. In both groups, total RNA from frontal cortex, hippocampus gastrocnemius was isolated sequenced, GO term KEGG...
Deprivation of rapid eye movement sleep (REMSD) reduces the potential for learning and memory. The neuronal foundation cognitive performance is synapse plasticity. MicroRNA-132 (MiR-132) an important microRNA related to Acupuncture effective at improving impairment caused by deprivation. Furthermore, its underlying principle still unclear. Herein, whether electroacupuncture (EA) helps alleviate in REMSD targeting miR-132 was assessed. A rat model constructed using developing multiplatform...
B cell adaptor molecule of 32 kDa (Bam32), also known as dual adapter for phosphotyrosine and 3-phosphoinositides 1 (DAPP1), has been indicated in regulating lymphocyte proliferation recruitment during inflammation. Its role neutrophils inflammation remains unknown. Using intravital microscopy, we examined the Bam32 formyl peptide WKYMVm-induced permeability changes post-capillary venules assessed simultaneously neutrophil adhesion emigration cremaster muscles Bam32-deficient (Bam32-/-)...
Alzheimer’s disease (AD) is an age-related neurodegenerative that progressively impairs cognitive function and memory. The occurrence development of involves many processes. In response to the complex pathogenesis AD, Traditional Chinese medicine formula Liuwei Dihuang Pill (LWD) has been shown improve AD animal models. However, active ingredients mechanism action LWD have not fully elucidated. this study, network pharmacological analysis predicted 40 candidate compounds in LWD, acting on...
PI3K has been indicated in regulating microvascular permeability changes during inflammation. However, its role neutrophil-driven leakage acute inflammation remains unclear. Using intravital microscopy mice, we examined the of PI3Kγ and PI3Kδ formyl peptide WKYMVm- chemokine CXCL2-induced assessed simultaneously neutrophil adhesion emigration post-capillary venules murine cremaster muscle. We found a PI3Kγ-specific mechanism WKYMVm-induced but not hyperpermeability. The increased triggered...
The main characteristic of Alzheimer's disease (AD) is the progressive decline learning and memory ability. Electroacupuncture (EA) may improve AD-related However, underlying molecular mechanism action remains unclear. objective present study was to assess effects EA on in an amyloid β25-35 (Aβ25-35) induced AD mouse model. model established by intracerebroventricular (ICV) administration Aβ25-35 oligomers. mice were electroacupunctured with wisdom three-needle combined Baihui (GV20) five...